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Items: 1 to 20 of 27


Novel protein therapeutic joint retention strategy based on collagen-binding Avimers.

Hulme JT, D'Souza WN, McBride HJ, Yoon BP, Willee AM, Duguay A, Thomas M, Fan B, Dayao MR, Rottman JB, Merriam K, Xie J, Smith R, Alba BM, Case RB, Dang K, Montalvan A, Grinberg N, Sun H, Black RA, Gabel CA, Sims JE, Moore K, Bakker A, Li P.

J Orthop Res. 2018 Apr;36(4):1238-1247. doi: 10.1002/jor.23756. Epub 2017 Nov 22.


Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction.

Eckhouse SR, Purcell BP, McGarvey JR, Lobb D, Logdon CB, Doviak H, O'Neill JW, Shuman JA, Novack CP, Zellars KN, Pettaway S, Black RA, Khakoo A, Lee T, Mukherjee R, Gorman JH, Gorman RC, Burdick JA, Spinale FG.

Sci Transl Med. 2014 Feb 12;6(223):223ra21. doi: 10.1126/scitranslmed.3007244.


Nucleobases bind to and stabilize aggregates of a prebiotic amphiphile, providing a viable mechanism for the emergence of protocells.

Black RA, Blosser MC, Stottrup BL, Tavakley R, Deamer DW, Keller SL.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13272-6. doi: 10.1073/pnas.1300963110. Epub 2013 Jul 30.


Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury.

Roudier M, Li X, Niu QT, Pacheco E, Pretorius JK, Graham K, Yoon BR, Gong J, Warmington K, Ke HZ, Black RA, Hulme J, Babij P.

Arthritis Rheum. 2013 Mar;65(3):721-31. doi: 10.1002/art.37802.


Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.

Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.

J Biol Chem. 2011 Dec 2;286(48):41530-8. doi: 10.1074/jbc.M111.248856. Epub 2011 Oct 10.


╬│-Secretase-mediated growth hormone receptor proteolysis: mapping of the intramembranous cleavage site.

Wang X, Cowan JW, Gerhart M, Zelickson BR, Jiang J, He K, Wolfe MS, Black RA, Frank SJ.

Biochem Biophys Res Commun. 2011 May 13;408(3):432-6. doi: 10.1016/j.bbrc.2011.04.041. Epub 2011 Apr 13.


Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.

Chen P, McGuire JK, Hackman RC, Kim KH, Black RA, Poindexter K, Yan W, Liu P, Chen AJ, Parks WC, Madtes DK.

Am J Pathol. 2008 May;172(5):1256-70. doi: 10.2353/ajpath.2008.070891. Epub 2008 Apr 1.


Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.

Srinivasan B, Wang Z, Brun-Zinkernagel AM, Collier RJ, Black RA, Frank SJ, Barker PA, Roque RS.

Mol Cell Neurosci. 2007 Dec;36(4):449-61. Epub 2007 Aug 15.


Metalloproteases regulate T-cell proliferation and effector function via LAG-3.

Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, Hartmann D, Black RA, Rossi JJ, Blobel CP, Dempsey PJ, Workman CJ, Vignali DA.

EMBO J. 2007 Jan 24;26(2):494-504.


ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.

Weskamp G, Ford JW, Sturgill J, Martin S, Docherty AJ, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Sehara-Fujisawa A, Black RA, Ludwig A, Becherer JD, Conrad DH, Blobel CP.

Nat Immunol. 2006 Dec;7(12):1293-8. Epub 2006 Oct 29.


Janus kinase 2 influences growth hormone receptor metalloproteolysis.

Loesch K, Deng L, Cowan JW, Wang X, He K, Jiang J, Black RA, Frank SJ.

Endocrinology. 2006 Jun;147(6):2839-49. Epub 2006 Feb 23.


Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

Cowan JW, Wang X, Guan R, He K, Jiang J, Baumann G, Black RA, Wolfe MS, Frank SJ.

J Biol Chem. 2005 May 13;280(19):19331-42. Epub 2005 Mar 2.


Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis.

Mezyk-Kopec R, Bzowska M, Potempa J, Bzowska M, Jura N, Sroka A, Black RA, Bereta J.

Infect Immun. 2005 Mar;73(3):1506-14.


TIMP3 checks inflammation.

Black RA.

Nat Genet. 2004 Sep;36(9):934-5.


Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells.

Bzowska M, Jura N, Lassak A, Black RA, Bereta J.

Eur J Biochem. 2004 Jul;271(13):2808-20.


Substrate specificity and inducibility of TACE (tumour necrosis factor alpha-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity.

Black RA, Doedens JR, Mahimkar R, Johnson R, Guo L, Wallace A, Virca D, Eisenman J, Slack J, Castner B, Sunnarborg SW, Lee DC, Cowling R, Jin G, Charrier K, Peschon JJ, Paxton R.

Biochem Soc Symp. 2003;(70):39-52. Review.


An assessment of ADAMs in bone cells: absence of TACE activity prevents osteoclast recruitment and the formation of the marrow cavity in developing long bones.

Boissy P, Lenhard TR, Kirkegaard T, Peschon JJ, Black RA, Delaiss├ę JM, del Carmen Ovejero M.

FEBS Lett. 2003 Oct 23;553(3):257-61.


TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation.

Doedens JR, Mahimkar RM, Black RA.

Biochem Biophys Res Commun. 2003 Aug 22;308(2):331-8.


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