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Items: 19


Characterization of Different Types of Excitability in Large Somatosensory Neurons and Its Plastic Changes in Pathological Pain States.

Xie RG, Chu WG, Hu SJ, Luo C.

Int J Mol Sci. 2018 Jan 5;19(1). pii: E161. doi: 10.3390/ijms19010161.


Chronic cervical radiculopathic pain is associated with increased excitability and hyperpolarization-activated current ( Ih) in large-diameter dorsal root ganglion neurons.

Liu DL, Wang X, Chu WG, Lu N, Han WJ, Du YK, Hu SJ, Bai ZT, Wu SX, Xie RG, Luo C.

Mol Pain. 2017 Jan-Dec;13:1744806917707127. doi: 10.1177/1744806917707127.


Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.

Zhong H, Tong L, Gu N, Gao F, Lu Y, Xie RG, Liu J, Li X, Bergeron R, Pomeranz LE, Mackie K, Wang F, Luo CX, Ren Y, Wu SX, Xie Z, Xu L, Li J, Dong H, Xiong L, Zhang X.

J Clin Invest. 2017 Jun 1;127(6):2295-2309. doi: 10.1172/JCI91038. Epub 2017 May 2.


Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms.

Xie RG, Gao YJ, Park CK, Lu N, Luo C, Wang WT, Wu SX, Ji RR.

Neurosci Bull. 2018 Feb;34(1):13-21. doi: 10.1007/s12264-017-0106-5. Epub 2017 Mar 6.


Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation.

Xiao MM, Zhang YQ, Wang WT, Han WJ, Lin Z, Xie RG, Cao Z, Lu N, Hu SJ, Wu SX, Dong H, Luo C.

Sci Rep. 2016 Nov 17;6:37251. doi: 10.1038/srep37251.


β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.

Chen G, Xie RG, Gao YJ, Xu ZZ, Zhao LX, Bang S, Berta T, Park CK, Lay M, Chen W, Ji RR.

Nat Commun. 2016 Aug 19;7:12531. doi: 10.1038/ncomms12531.


Upregulation of Ih expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain.

Liu DL, Lu N, Han WJ, Chen RG, Cong R, Xie RG, Zhang YF, Kong WW, Hu SJ, Luo C.

Sci Rep. 2015 Nov 18;5:16713. doi: 10.1038/srep16713.


Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion.

Chen G, Park CK, Xie RG, Ji RR.

J Clin Invest. 2015 Aug 3;125(8):3226-40. doi: 10.1172/JCI80883. Epub 2015 Jul 13.


A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.

Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R.

Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038/ncomms7820.


Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.

Chen G, Park CK, Xie RG, Berta T, Nedergaard M, Ji RR.

Brain. 2014 Aug;137(Pt 8):2193-209. doi: 10.1093/brain/awu140. Epub 2014 Jun 11.


A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief.

Lee JH, Park CK, Chen G, Han Q, Xie RG, Liu T, Ji RR, Lee SY.

Cell. 2014 Jun 5;157(6):1393-404. doi: 10.1016/j.cell.2014.03.064. Epub 2014 May 22.


Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2.

Cao DL, Zhang ZJ, Xie RG, Jiang BC, Ji RR, Gao YJ.

Exp Neurol. 2014 Nov;261:328-36. doi: 10.1016/j.expneurol.2014.05.014. Epub 2014 May 20.


Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels.

Pagadala P, Park CK, Bang S, Xu ZZ, Xie RG, Liu T, Han BX, Tracey WD Jr, Wang F, Ji RR.

J Neurosci. 2013 Aug 14;33(33):13425-30. doi: 10.1523/JNEUROSCI.0454-13.2013.


Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.

Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R.

PLoS Biol. 2012;10(3):e1001283. doi: 10.1371/journal.pbio.1001283. Epub 2012 Mar 13.


Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats.

Sun W, Miao B, Wang XC, Duan JH, Wang WT, Kuang F, Xie RG, Xing JL, Xu H, Song XJ, Luo C, Hu SJ.

Brain. 2012 Feb;135(Pt 2):359-75. doi: 10.1093/brain/awr345. Epub 2012 Jan 23.


Evoked bursting in injured Aβ dorsal root ganglion neurons: a mechanism underlying tactile allodynia.

Song Y, Li HM, Xie RG, Yue ZF, Song XJ, Hu SJ, Xing JL.

Pain. 2012 Mar;153(3):657-65. doi: 10.1016/j.pain.2011.11.030. Epub 2012 Jan 9.


Membrane resonance and its ionic mechanisms in rat subthalamic nucleus neurons.

Yan ZQ, Liu SM, Li J, Wang Y, Gao L, Xie RG, Xue WN, Zhang GL, Zhu JL, Gao GD.

Neurosci Lett. 2012 Jan 6;506(1):160-5. doi: 10.1016/j.neulet.2011.10.072. Epub 2011 Nov 9.


Blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured DRG neurons.

Xie RG, Zheng DW, Xing JL, Zhang XJ, Song Y, Xie YB, Kuang F, Dong H, You SW, Xu H, Hu SJ.

PLoS One. 2011 Apr 25;6(4):e18681. doi: 10.1371/journal.pone.0018681.


Gabapentin selectively reduces persistent sodium current in injured type-A dorsal root ganglion neurons.

Yang RH, Wang WT, Chen JY, Xie RG, Hu SJ.

Pain. 2009 May;143(1-2):48-55. doi: 10.1016/j.pain.2009.01.020. Epub 2009 Mar 9.


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