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Items: 1 to 20 of 54

1.

The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer.

Florio R, Veschi S, di Giacomo V, Pagotto S, Carradori S, Verginelli F, Cirilli R, Casulli A, Grassadonia A, Tinari N, Cataldi A, Amoroso R, Cama A, De Lellis L.

Cancers (Basel). 2019 Dec 17;11(12). pii: E2042. doi: 10.3390/cancers11122042.

2.

Targeting iNOS As a Valuable Strategy for the Therapy of Glioma.

Maccallini C, Gallorini M, Cataldi A, Amoroso R.

ChemMedChem. 2019 Dec 18. doi: 10.1002/cmdc.201900580. [Epub ahead of print] Review.

PMID:
31851765
3.

Synthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors.

Fantacuzzi M, De Filippis B, Gallorini M, Ammazzalorso A, Giampietro L, Maccallini C, Aturki Z, Donati E, Ibrahim RS, Shawky E, Cataldi A, Amoroso R.

Eur J Med Chem. 2020 Jan 1;185:111815. doi: 10.1016/j.ejmech.2019.111815. Epub 2019 Oct 31.

PMID:
31732252
4.

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold.

Rotondi G, Guglielmi P, Carradori S, Secci D, De Monte C, De Filippis B, Maccallini C, Amoroso R, Cirilli R, Akdemir A, Angeli A, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1400-1413. doi: 10.1080/14756366.2019.1651315.

5.

Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines.

Ammazzalorso A, De Lellis L, Florio R, Laghezza A, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Tortorella P, Veschi S, Loiodice F, Cama A, Amoroso R.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2302-2306. doi: 10.1016/j.bmcl.2019.06.020. Epub 2019 Jun 18.

PMID:
31272790
6.

PPAR Ligands Containing Stilbene Scaffold.

Fantacuzzi M, De Filippis B, Amoroso R, Giampietro L.

Mini Rev Med Chem. 2019;19(19):1599-1610. doi: 10.2174/1389557519666190603085026. Review.

PMID:
31161987
7.

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.

Ammazzalorso A, Carradori S, Angeli A, Akdemir A, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1051-1061. doi: 10.1080/14756366.2019.1611801.

8.

Multitarget PPARγ agonists as innovative modulators of the metabolic syndrome.

Ammazzalorso A, Maccallini C, Amoia P, Amoroso R.

Eur J Med Chem. 2019 Jul 1;173:261-273. doi: 10.1016/j.ejmech.2019.04.030. Epub 2019 Apr 13. Review.

PMID:
31009912
9.

Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.

Giampietro L, Laghezza A, Cerchia C, Florio R, Recinella L, Capone F, Ammazzalorso A, Bruno I, De Filippis B, Fantacuzzi M, Ferrante C, Maccallini C, Tortorella P, Verginelli F, Brunetti L, Cama A, Amoroso R, Loiodice F, Lavecchia A.

ACS Med Chem Lett. 2019 Feb 25;10(4):545-551. doi: 10.1021/acsmedchemlett.8b00574. eCollection 2019 Apr 11.

PMID:
30996794
10.

Development of Fibrates as Important Scaffolds in Medicinal Chemistry.

Giampietro L, Ammazzalorso A, Amoroso R, De Filippis B.

ChemMedChem. 2019 Jun 5;14(11):1051-1066. doi: 10.1002/cmdc.201900128. Epub 2019 May 7. Review.

PMID:
30957432
11.

PPAR-γ agonist GL516 reduces oxidative stress and apoptosis occurrence in a rat astrocyte cell line.

Giampietro L, Gallorini M, De Filippis B, Amoroso R, Cataldi A, di Giacomo V.

Neurochem Int. 2019 Jun;126:239-245. doi: 10.1016/j.neuint.2019.03.021. Epub 2019 Apr 1.

PMID:
30946848
12.

Stilbene derivatives as new perspective in antifungal medicinal chemistry.

De Filippis B, Ammazzalorso A, Amoroso R, Giampietro L.

Drug Dev Res. 2019 May;80(3):285-293. doi: 10.1002/ddr.21525. Epub 2019 Feb 20.

PMID:
30790326
13.

The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro.

Gallorini M, Maccallini C, Ammazzalorso A, Amoia P, De Filippis B, Fantacuzzi M, Giampietro L, Cataldi A, Amoroso R.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E495. doi: 10.3390/ijms20030495.

14.

Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking.

Giancristofaro A, Barbosa AJM, Ammazzalorso A, Amoia P, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R.

Medchemcomm. 2018 Jul 4;9(10):1630-1638. doi: 10.1039/c8md00272j. eCollection 2018 Oct 1.

15.

Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells.

Florio R, De Lellis L, Veschi S, Verginelli F, di Giacomo V, Gallorini M, Perconti S, Sanna M, Mariani-Costantini R, Natale A, Arduini A, Amoroso R, Cataldi A, Cama A.

Sci Rep. 2018 Sep 11;8(1):13610. doi: 10.1038/s41598-018-31797-5.

16.

Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.

Maccallini C, Di Matteo M, Gallorini M, Montagnani M, Graziani V, Ammazzalorso A, Amoia P, De Filippis B, Di Silvestre S, Fantacuzzi M, Giampietro L, Potenza MA, Re N, Pandolfi A, Cataldi A, Amoroso R.

Eur J Med Chem. 2018 May 25;152:53-64. doi: 10.1016/j.ejmech.2018.04.027. Epub 2018 Apr 13.

PMID:
29689474
17.

The Anticancer Potential of Peroxisome Proliferator-Activated Receptor Antagonists.

De Lellis L, Cimini A, Veschi S, Benedetti E, Amoroso R, Cama A, Ammazzalorso A.

ChemMedChem. 2018 Feb 6;13(3):209-219. doi: 10.1002/cmdc.201700703. Epub 2018 Jan 10. Review.

PMID:
29276815
18.

N-acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry.

Ammazzalorso A, De Filippis B, Giampietro L, Amoroso R.

Chem Biol Drug Des. 2017 Dec;90(6):1094-1105. doi: 10.1111/cbdd.13043. Epub 2017 Jul 11. Review.

PMID:
28632928
19.

Cytotoxic effect of a family of peroxisome proliferator-activated receptor antagonists in colorectal and pancreatic cancer cell lines.

Ammazzalorso A, De Lellis L, Florio R, Bruno I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Perconti S, Verginelli F, Cama A, Amoroso R.

Chem Biol Drug Des. 2017 Nov;90(5):1029-1035. doi: 10.1111/cbdd.13026. Epub 2017 Jul 19.

PMID:
28544586
20.

The Positive Regulation of eNOS Signaling by PPAR Agonists in Cardiovascular Diseases.

Maccallini C, Mollica A, Amoroso R.

Am J Cardiovasc Drugs. 2017 Aug;17(4):273-281. doi: 10.1007/s40256-017-0220-9. Review.

PMID:
28315197

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