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Items: 1 to 20 of 218

1.

Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.

Kany AM, Sikandar A, Yahiaoui S, Haupenthal J, Walter I, Empting M, Köhnke J, Hartmann RW.

ACS Chem Biol. 2018 Aug 24. doi: 10.1021/acschembio.8b00257. [Epub ahead of print]

PMID:
30088919
2.

Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.

El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW, Abadi AH.

Arch Pharm (Weinheim). 2018 May;351(5):e1800018. doi: 10.1002/ardp.201800018. Epub 2018 Apr 14.

PMID:
29656464
3.

Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.

Kany AM, Sikandar A, Haupenthal J, Yahiaoui S, Maurer CK, Proschak E, Köhnke J, Hartmann RW.

ACS Infect Dis. 2018 Jun 8;4(6):988-997. doi: 10.1021/acsinfecdis.8b00010. Epub 2018 Mar 6.

PMID:
29485268
4.

Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors.

Akram M, Waratchareeyakul W, Haupenthal J, Hartmann RW, Schuster D.

Front Chem. 2017 Dec 19;5:104. doi: 10.3389/fchem.2017.00104. eCollection 2017.

5.

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa.

Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A.

J Am Chem Soc. 2018 Feb 21;140(7):2537-2545. doi: 10.1021/jacs.7b11133. Epub 2018 Jan 22.

PMID:
29272578
6.

Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach.

Surup F, Viehrig K, Rachid S, Plaza A, Maurer CK, Hartmann RW, Müller R.

ACS Chem Biol. 2018 Jan 19;13(1):267-272. doi: 10.1021/acschembio.7b00900. Epub 2017 Dec 28.

PMID:
29220569
7.

Accelerated skin wound healing by selective 11β-Hydroxylase (CYP11B1) inhibitors.

Emmerich J, van Koppen CJ, Burkhart JL, Engeli RT, Hu Q, Odermatt A, Hartmann RW.

Eur J Med Chem. 2018 Jan 1;143:591-597. doi: 10.1016/j.ejmech.2017.11.018. Epub 2017 Nov 21.

PMID:
29207342
8.

CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone.

de Mello Martins AGG, Allegretta G, Unteregger G, Haupenthal J, Eberhard J, Hoffmann M, van der Zee JA, Junker K, Stöckle M, Müller R, Hartmann RW, Ohlmann CH.

J Steroid Biochem Mol Biol. 2017 Nov;174:183-191. doi: 10.1016/j.jsbmb.2017.09.006. Epub 2017 Sep 7.

PMID:
28890368
9.

Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.

Schönauer E, Kany AM, Haupenthal J, Hüsecken K, Hoppe IJ, Voos K, Yahiaoui S, Elsässer B, Ducho C, Brandstetter H, Hartmann RW.

J Am Chem Soc. 2017 Sep 13;139(36):12696-12703. doi: 10.1021/jacs.7b06935. Epub 2017 Aug 31.

10.

Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials.

Brengel C, Thomann A, Schifrin A, Allegretta G, Kamal AAM, Haupenthal J, Schnorr I, Cho SH, Franzblau SG, Empting M, Eberhard J, Hartmann RW.

ChemMedChem. 2017 Oct 9;12(19):1616-1626. doi: 10.1002/cmdc.201700363. Epub 2017 Sep 26.

PMID:
28815923
11.

Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1.

Gobbi S, Hu Q, Zimmer C, Belluti F, Rampa A, Hartmann RW, Bisi A.

Eur J Med Chem. 2017 Oct 20;139:60-67. doi: 10.1016/j.ejmech.2017.07.078. Epub 2017 Aug 2.

PMID:
28797884
12.

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment.

Allegretta G, Maurer CK, Eberhard J, Maura D, Hartmann RW, Rahme L, Empting M.

Front Microbiol. 2017 May 24;8:924. doi: 10.3389/fmicb.2017.00924. eCollection 2017.

13.

Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease.

Emmerich J, van Koppen CJ, Burkhart JL, Hu Q, Siebenbürger L, Boerger C, Scheuer C, Laschke MW, Menger MD, Hartmann RW.

J Med Chem. 2017 Jun 22;60(12):5086-5098. doi: 10.1021/acs.jmedchem.7b00437. Epub 2017 Jun 9.

PMID:
28570067
14.

Structure-functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators.

Kamal AAM, Petrera L, Eberhard J, Hartmann RW.

Org Biomol Chem. 2017 May 31;15(21):4620-4630. doi: 10.1039/c7ob00263g.

PMID:
28513746
15.

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.

Fazli M, Rybtke M, Steiner E, Weidel E, Berthelsen J, Groizeleau J, Bin W, Zhi BZ, Yaming Z, Kaever V, Givskov M, Hartmann RW, Eberl L, Tolker-Nielsen T.

Microbiologyopen. 2017 Aug;6(4). doi: 10.1002/mbo3.480. Epub 2017 Apr 16.

16.

Metal-Free meta-Selective Alkyne Oxyarylation with Pyridine N-Oxides: Rapid Assembly of Metyrapone Analogues.

Chen X, Ruider SA, Hartmann RW, González L, Maulide N.

Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15424-15428. doi: 10.1002/anie.201607988. Epub 2016 Nov 9.

PMID:
27862782
17.

Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa.

Thomann A, Brengel C, Börger C, Kail D, Steinbach A, Empting M, Hartmann RW.

ChemMedChem. 2016 Nov 21;11(22):2522-2533. doi: 10.1002/cmdc.201600419. Epub 2016 Oct 12.

PMID:
27731921
18.

Discovery and Biophysical Evaluation of First Low Nanomolar Hits Targeting CYP125 of M. tuberculosis.

Brengel C, Thomann A, Schifrin A, Eberhard J, Hartmann RW.

ChemMedChem. 2016 Sep 28. doi: 10.1002/cmdc.201600361. [Epub ahead of print]

PMID:
27677638
19.

Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).

Abdel-Halim M, Darwish SS, ElHady AK, Hoppstädter J, Abadi AH, Hartmann RW, Kiemer AK, Engel M.

Eur J Pharm Sci. 2016 Oct 10;93:405-9. doi: 10.1016/j.ejps.2016.08.016. Epub 2016 Aug 8.

PMID:
27516147
20.

Specificity of anti-prostate cancer CYP17A1 inhibitors on androgen biosynthesis.

Udhane SS, Dick B, Hu Q, Hartmann RW, Pandey AV.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):1005-1010. doi: 10.1016/j.bbrc.2016.07.019. Epub 2016 Jul 6.

PMID:
27395338

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