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Items: 1 to 20 of 149


Human peptide α-defensin-1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT.

Fischer S, Ückert AK, Landenberger M, Papatheodorou P, Hoffmann-Richter C, Mittler AK, Ziener U, Hägele M, Schwan C, Müller M, Kleger A, Benz R, Popoff MR, Aktories K, Barth H.

FASEB J. 2020 Mar 19. doi: 10.1096/fj.201902816R. [Epub ahead of print]


Membrane Activity and Channel Formation of the Adenylate Cyclase Toxin (CyaA) of Bordetella pertussis in Lipid Bilayer Membranes.

Knapp O, Benz R.

Toxins (Basel). 2020 Mar 10;12(3). pii: E169. doi: 10.3390/toxins12030169. Review.


Aggregatibacter actinomycetemcomitans LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes.

Lally ET, Boesze-Battaglia K, Dhingra A, Gomez NM, Lora J, Mitchell CH, Giannakakis A, Fahim SA, Benz R, Balashova N.

Pathogens. 2020 Jan 21;9(2). pii: E74. doi: 10.3390/pathogens9020074.


Structure of a Tc holotoxin pore provides insights into the translocation mechanism.

Roderer D, Hofnagel O, Benz R, Raunser S.

Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23083-23090. doi: 10.1073/pnas.1909821116. Epub 2019 Oct 30.


Role of AIP56 disulphide bond and its reduction by cytosolic redox systems for efficient intoxication.

Pereira C, Rodrigues IS, Pereira LMG, Lisboa J, Pinto RD, Araújo L, Oliveira P, Benz R, Dos Santos NMS, do Vale A.

Cell Microbiol. 2020 Jan;22(1):e13109. doi: 10.1111/cmi.13109. Epub 2019 Sep 11.


Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication.

Schnell L, Felix I, Müller B, Sadi M, von Bank F, Papatheodorou P, Popoff MR, Aktories K, Waltenberger E, Benz R, Weichbrodt C, Fauler M, Frick M, Barth H.

FASEB J. 2019 Apr;33(4):5755-5771. doi: 10.1096/fj.201802453R. Epub 2019 Jan 30.


Clostridium perfringens Enterotoxin: The Toxin Forms Highly Cation-Selective Channels in Lipid Bilayers.

Benz R, Popoff MR.

Toxins (Basel). 2018 Aug 22;10(9). pii: E341. doi: 10.3390/toxins10090341.


Generation of a recombinant Aggregatibacter actinomycetemcomitans RTX toxin in Escherichia coli.

Balashova N, Giannakakis A, Brown AC, Koufos E, Benz R, Arakawa T, Tang HY, Lally ET.

Gene. 2018 Sep 25;672:106-114. doi: 10.1016/j.gene.2018.06.003. Epub 2018 Jun 4.


The major outer membrane protein of Legionella pneumophila Lpg1974 shows pore-forming characteristics similar to the human mitochondrial outer membrane pore, hVDAC1.

Younas F, Soltanmohammadi N, Knapp O, Benz R.

Biochim Biophys Acta Biomembr. 2018 Aug;1860(8):1544-1553. doi: 10.1016/j.bbamem.2018.05.008. Epub 2018 May 19.


Identification and characterization of smallest pore-forming protein in the cell wall of pathogenic Corynebacterium urealyticum DSM 7109.

Abdali N, Younas F, Mafakheri S, Pothula KR, Kleinekathöfer U, Tauch A, Benz R.

BMC Biochem. 2018 May 9;19(1):3. doi: 10.1186/s12858-018-0093-9.


Characterization of the first planctomycetal outer membrane protein identifies a channel in the outer membrane of the anammox bacterium Kuenenia stuttgartiensis.

van Teeseling MCF, Benz R, de Almeida NM, Jetten MSM, Mesman RJ, van Niftrik L.

Biochim Biophys Acta Biomembr. 2018 Mar;1860(3):767-776. doi: 10.1016/j.bbamem.2017.12.020. Epub 2017 Dec 27.


The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.

Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A.

EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825.


Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation.

Hupp S, Ribes S, Seele J, Bischoff C, Förtsch C, Maier E, Benz R, Mitchell TJ, Nau R, Iliev AI.

Br J Pharmacol. 2017 Dec;174(23):4295-4307. doi: 10.1111/bph.14027. Epub 2017 Oct 19.


Identification and characterization of a cell wall porin from Gordonia jacobaea.

Jiménez-Galisteo G, Fusté E, Muñoz E, Vinuesa T, Villa TG, Benz R, Domínguez A, Viñas M.

J Gen Appl Microbiol. 2017 Nov 17;63(5):266-273. doi: 10.2323/jgam.2017.01.001. Epub 2017 Aug 23.


Conversion of OprO into an OprP-like Channel by Exchanging Key Residues in the Channel Constriction.

Ganguly S, Kesireddy A, Bárcena-Uribarri I, Kleinekathöfer U, Benz R.

Biophys J. 2017 Aug 22;113(4):829-834. doi: 10.1016/j.bpj.2017.07.004.


Toxin Transport by A-B Type of Toxins in Eukaryotic Target Cells and Its Inhibition by Positively Charged Heterocyclic Molecules.

Benz R, Barth H.

Curr Top Microbiol Immunol. 2017;406:229-256. doi: 10.1007/82_2017_17. Review.


Single Residue Acts as Gate in OccK Channels.

Pothula KR, Dhanasekar NN, Lamichhane U, Younas F, Pletzer D, Benz R, Winterhalter M, Kleinekathöfer U.

J Phys Chem B. 2017 Mar 30;121(12):2614-2621. doi: 10.1021/acs.jpcb.7b01787. Epub 2017 Mar 21.


Chloroquine Analog Interaction with C2- and Iota-Toxin in Vitro and in Living Cells.

Kronhardt A, Beitzinger C, Barth H, Benz R.

Toxins (Basel). 2016 Aug 10;8(8). pii: E237. doi: 10.3390/toxins8080237.


A Review on the Valorization of Macroalgal Wastes for Biomethane Production.

Barbot YN, Al-Ghaili H, Benz R.

Mar Drugs. 2016 Jun 21;14(6). pii: E120. doi: 10.3390/md14060120. Review.

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