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Items: 1 to 20 of 43


Topical delivery of mTOR inhibitor halts scarring.

Webber LP, Yip B, Nascimento Filho CHVD, Park HB, Castilho RM, Squarize CH.

J Dermatol Sci. 2019 Jul 4. pii: S0923-1811(19)30175-6. doi: 10.1016/j.jdermsci.2019.06.008. [Epub ahead of print] No abstract available.


Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence.

Webber LP, Yujra VQ, Vargas PA, Martins MD, Squarize CH, Castilho RM.

Cancer Lett. 2019 Oct 1;461:10-20. doi: 10.1016/j.canlet.2019.06.019. Epub 2019 Jun 29.


Characterization of macrophage polarization in periodontal disease.

Garaicoa-Pazmino C, Fretwurst T, Squarize CH, Berglundh T, Giannobile WV, Larsson L, Castilho RM.

J Clin Periodontol. 2019 Aug;46(8):830-839. doi: 10.1111/jcpe.13156. Epub 2019 Jun 25.


Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Markman RL, Webber LP, Nascimento Filho CHV, Reis LA, Vargas PA, Lopes MA, Zanella V, Martins MD, Squarize CH, Castilho RM.

Cell Oncol (Dordr). 2019 Apr;42(2):143-155. doi: 10.1007/s13402-018-0416-2. Epub 2018 Dec 11.


UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.

Warner KA, Oklejas AE, Pearson AT, Zhang Z, Wu W, Divi V, Rodriguez-Ramirez C, Castilho RM, Polverini PJ, Nör JE.

Oral Oncol. 2018 Dec;87:21-28. doi: 10.1016/j.oraloncology.2018.10.012. Epub 2018 Oct 18.


Dental implants-associated release of titanium particles: A systematic review.

Suárez-López Del Amo F, Garaicoa-Pazmiño C, Fretwurst T, Castilho RM, Squarize CH.

Clin Oral Implants Res. 2018 Oct 2. doi: 10.1111/clr.13372. [Epub ahead of print] Review.


Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas.

Wagner VP, Martins MD, Martins MAT, Almeida LO, Warner KA, Nör JE, Squarize CH, Castilho RM.

Sci Rep. 2018 Feb 1;8(1):2065. doi: 10.1038/s41598-018-20345-w.


DNA intercalators based on (1,10-phenanthrolin-2-yl)isoxazolidin-5-yl core with better growth inhibition and selectivity than cisplatin upon head and neck squamous cells carcinoma.

Varrica MG, Zagni C, Mineo PG, Floresta G, Monciino G, Pistarà V, Abbadessa A, Nicosia A, Castilho RM, Amata E, Rescifina A.

Eur J Med Chem. 2018 Jan 1;143:583-590. doi: 10.1016/j.ejmech.2017.11.067. Epub 2017 Nov 26.


Titanium Activates the DNA Damage Response Pathway in Oral Epithelial Cells: A Pilot Study.

Suárez-López Del Amo F, Rudek I, Wagner VP, Martins MD, O'Valle F, Galindo-Moreno P, Giannobile WV, Wang HL, Castilho RM.

Int J Oral Maxillofac Implants. 2017 Nov/Dec;32(6):1413-1420. doi: 10.11607/jomi.6077.


Serendipitous discovery of potent human head and neck squamous cell carcinoma anti-cancer molecules: A fortunate failure of a rational molecular design.

Zagni C, Pistarà V, Oliveira LA, Castilho RM, Romeo G, Chiacchio U, Rescifina A.

Eur J Med Chem. 2017 Dec 1;141:188-196. doi: 10.1016/j.ejmech.2017.09.075. Epub 2017 Oct 5.


When epigenetics meets bioengineering-A material characteristics and surface topography perspective.

Larsson L, Pilipchuk SP, Giannobile WV, Castilho RM.

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):2065-2071. doi: 10.1002/jbm.b.33953. Epub 2017 Jul 25. Review.


Evaluation of DNA methylation of inflammatory genes following treatment of chronic periodontitis: A pilot case-control study.

Asa'ad F, Bollati V, Pagni G, Castilho RM, Rossi E, Pomingi F, Tarantini L, Consonni D, Giannobile WV, Rasperini G.

J Clin Periodontol. 2017 Sep;44(9):905-914. doi: 10.1111/jcpe.12783. Epub 2017 Aug 17.


Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.

Castilho RM, Squarize CH, Almeida LO.

Int J Mol Sci. 2017 Jul 12;18(7). pii: E1506. doi: 10.3390/ijms18071506. Review.


PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells.

Zagni C, Almeida LO, Balan T, Martins MT, Rosselli-Murai LK, Papagerakis P, Castilho RM, Squarize CH.

Stem Cell Reports. 2017 Jul 11;9(1):304-314. doi: 10.1016/j.stemcr.2017.05.006. Epub 2017 Jun 8.


Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.

Almeida LO, Guimarães DM, Martins MD, Martins MAT, Warner KA, Nör JE, Castilho RM, Squarize CH.

Stem Cell Res. 2017 May;21:94-105. doi: 10.1016/j.scr.2017.04.003. Epub 2017 Apr 8. No abstract available.


Hypoacetylation of acetyl-histone H3 (H3K9ac) as marker of poor prognosis in oral cancer.

Webber LP, Wagner VP, Curra M, Vargas PA, Meurer L, Carrard VC, Squarize CH, Castilho RM, Martins MD.

Histopathology. 2017 Aug;71(2):278-286. doi: 10.1111/his.13218. Epub 2017 May 23.


Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis.

Wagner VP, Martins MA, Martins MD, Warner KA, Webber LP, Squarize CH, Nör JE, Castilho RM.

Oncotarget. 2016 Nov 8;7(45):73032-73044. doi: 10.18632/oncotarget.12195.


Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells.

Guimarães DM, Almeida LO, Martins MD, Warner KA, Silva AR, Vargas PA, Nunes FD, Squarize CH, Nör JE, Castilho RM.

Oncotarget. 2016 Jul 5;7(27):42447-42460. doi: 10.18632/oncotarget.9884.


PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.

Matsumoto CS, Almeida LO, Guimarães DM, Martins MD, Papagerakis P, Papagerakis S, Leopoldino AM, Castilho RM, Squarize CH.

Oncotarget. 2016 Jul 5;7(27):42393-42407. doi: 10.18632/oncotarget.9877.


Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma.

Warner KA, Nör F, Acasigua GA, Martins MD, Zhang Z, McLean SA, Spector ME, Chepeha DB, Helman J, Wick MJ, Moskaluk CA, Castilho RM, Pearson AT, Wang S, Nör JE.

Clin Cancer Res. 2016 Jul 15;22(14):3550-9. doi: 10.1158/1078-0432.CCR-15-1698. Epub 2016 Mar 2.

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