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Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms.

Dekkers S, Ma-Hock L, Lynch I, Russ M, Miller MR, Schins RPF, Keller J, Römer I, Küttler K, Strauss V, De Jong WH, Landsiedel R, Cassee FR.

Inhal Toxicol. 2018 Jun - Jul;30(7-8):273-286. doi: 10.1080/08958378.2018.1516834. Epub 2018 Oct 4.


Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells.

Perkins TN, Peeters PM, Albrecht C, Schins RPF, Dentener MA, Mossman BT, Wouters EFM, Reynaert NL.

Toxicol Appl Pharmacol. 2018 Jun 1;348:43-53. doi: 10.1016/j.taap.2018.04.011. Epub 2018 Apr 17.


Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge.

Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Alstrup Jensen K, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Teixeira JP, Tran CL, Cassee FR.

Environ Health Perspect. 2017 Oct 10;125(10):106002. doi: 10.1289/EHP424. Review.


Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.

Hullmann M, Albrecht C, van Berlo D, Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins RPF.

Part Fibre Toxicol. 2017 Aug 30;14(1):35. doi: 10.1186/s12989-017-0213-5.


The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation.

Dekkers S, Miller MR, Schins RPF, Römer I, Russ M, Vandebriel RJ, Lynch I, Belinga-Desaunay MF, Valsami-Jones E, Connell SP, Smith IP, Duffin R, Boere JAF, Heusinkveld HJ, Albrecht C, de Jong WH, Cassee FR.

Nanotoxicology. 2017 Aug;11(6):794-808. doi: 10.1080/17435390.2017.1357214. Epub 2017 Aug 9.


Arterial blood pressure responses to short-term exposure to fine and ultrafine particles from indoor sources - A randomized sham-controlled exposure study of healthy volunteers.

Soppa VJ, Schins RPF, Hennig F, Nieuwenhuijsen MJ, Hellack B, Quass U, Kaminski H, Sasse B, Shinnawi S, Kuhlbusch TAJ, Hoffmann B.

Environ Res. 2017 Oct;158:225-232. doi: 10.1016/j.envres.2017.06.006. Epub 2017 Jul 3.


Silver nanoparticles induce hormesis in A549 human epithelial cells.

Sthijns MM, Thongkam W, Albrecht C, Hellack B, Bast A, Haenen GR, Schins RP.

Toxicol In Vitro. 2017 Apr;40:223-233. doi: 10.1016/j.tiv.2017.01.010. Epub 2017 Jan 18.


Oxidant generation, DNA damage and cytotoxicity by a panel of engineered nanomaterials in three different human epithelial cell lines.

Thongkam W, Gerloff K, van Berlo D, Albrecht C, Schins RP.

Mutagenesis. 2017 Jan;32(1):105-115. doi: 10.1093/mutage/gew056. Epub 2016 Nov 10.


Neurodegenerative and neurological disorders by small inhaled particles.

Heusinkveld HJ, Wahle T, Campbell A, Westerink RHS, Tran L, Johnston H, Stone V, Cassee FR, Schins RPF.

Neurotoxicology. 2016 Sep;56:94-106. doi: 10.1016/j.neuro.2016.07.007. Epub 2016 Jul 19. Review.


A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health--ENPRA Project--The Highlights, Limitations, and Current and Future Challenges.

Kermanizadeh A, Gosens I, MacCalman L, Johnston H, Danielsen PH, Jacobsen NR, Lenz AG, Fernandes T, Schins RP, Cassee FR, Wallin H, Kreyling W, Stoeger T, Loft S, Møller P, Tran L, Stone V.

J Toxicol Environ Health B Crit Rev. 2016;19(1):1-28. doi: 10.1080/10937404.2015.1126210. Review.


Oxidative potential of particulate matter at a German motorway.

Hellack B, Quass U, Nickel C, Wick G, Schins RP, Kuhlbusch TA.

Environ Sci Process Impacts. 2015 Apr;17(4):868-76. doi: 10.1039/c4em00605d.


Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children.

Klümper C, Krämer U, Lehmann I, von Berg A, Berdel D, Herberth G, Beckmann C, Link E, Heinrich J, Hoffmann B, Schins RP; GINIplus and LISAplus study groups.

Environ Res. 2015 Apr;138:381-90. doi: 10.1016/j.envres.2015.02.034. Epub 2015 Mar 10.


Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs.

Peeters PM, Eurlings IM, Perkins TN, Wouters EF, Schins RP, Borm PJ, Drommer W, Reynaert NL, Albrecht C.

Part Fibre Toxicol. 2014 Nov 19;11:58. doi: 10.1186/s12989-014-0058-0.


Respiratory effects of fine and ultrafine particles from indoor sources--a randomized sham-controlled exposure study of healthy volunteers.

Soppa VJ, Schins RP, Hennig F, Hellack B, Quass U, Kaminski H, Kuhlbusch TA, Hoffmann B, Weinmayr G.

Int J Environ Res Public Health. 2014 Jul 4;11(7):6871-89. doi: 10.3390/ijerph110706871.


A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes.

Clift MJ, Endes C, Vanhecke D, Wick P, Gehr P, Schins RP, Petri-Fink A, Rothen-Rutishauser B.

Toxicol Sci. 2014 Jan;137(1):55-64. doi: 10.1093/toxsci/kft216. Epub 2013 Nov 27.


Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner.

Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RP, Albrecht C.

PLoS One. 2013 Jun 3;8(6):e65704. doi: 10.1371/journal.pone.0065704. Print 2013.


Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria.

Clift MJ, Raemy DO, Endes C, Ali Z, Lehmann AD, Brandenberger C, Petri-Fink A, Wick P, Parak WJ, Gehr P, Schins RP, Rothen-Rutishauser B.

Nanotoxicology. 2013 Dec;7(8):1373-85. doi: 10.3109/17435390.2012.741725. Epub 2012 Nov 12.


Toxicology of ambient particulate matter.

van Berlo D, Hullmann M, Schins RP.

Exp Suppl. 2012;101:165-217. doi: 10.1007/978-3-7643-8340-4_7. Review.


Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells.

Boots AW, Gerloff K, Bartholomé R, van Berlo D, Ledermann K, Haenen GR, Bast A, van Schooten FJ, Albrecht C, Schins RP.

Biochim Biophys Acta. 2012 Jul;1823(7):1151-62. doi: 10.1016/j.bbamcr.2012.04.012. Epub 2012 May 1.


Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells.

Gerloff K, Pereira DI, Faria N, Boots AW, Kolling J, Förster I, Albrecht C, Powell JJ, Schins RP.

Nanotoxicology. 2013 Jun;7(4):353-66. doi: 10.3109/17435390.2012.662249. Epub 2012 Mar 20.

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