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Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure.

Chen Z, Diaz G, Pollicino T, Zhao H, Engle RE, Schuck P, Shen CH, Zamboni F, Long Z, Kabat J, De Battista D, Bock KW, Moore IN, Wollenberg K, Soto C, Govindarajan S, Kwong PD, Kleiner DE, Purcell RH, Farci P.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11369-E11378. doi: 10.1073/pnas.1809028115. Epub 2018 Nov 12.


The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-β1.

Lawson JS, Liu HH, Syme HM, Purcell R, Wheeler-Jones CPD, Elliott J.

PLoS One. 2018 Aug 23;13(8):e0202577. doi: 10.1371/journal.pone.0202577. eCollection 2018.


Hepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Uganda.

Boon D, Redd AD, Laeyendecker O, Engle RE, Nguyen H, Ocama P, Boaz I, Ndyanabo A, Kiggundu V, Reynolds SJ, Gray RH, Wawer MJ, Purcell RH, Kirk GD, Quinn TC, Stabinski L; Rakai Health Sciences Program.

J Infect Dis. 2018 Feb 14;217(5):785-789. doi: 10.1093/infdis/jix610.


Phenotypic heterogeneity of peripheral monocytes in healthy dogs.

Gibbons N, Goulart MR, Chang YM, Efstathiou K, Purcell R, Wu Y, Peters LM, Turmaine M, Szladovits B, Garden OA.

Vet Immunol Immunopathol. 2017 Aug;190:26-30. doi: 10.1016/j.vetimm.2017.06.007. Epub 2017 Jun 28.


Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology.

Fioravanti J, Di Lucia P, Magini D, Moalli F, Boni C, Benechet AP, Fumagalli V, Inverso D, Vecchi A, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M.

J Hepatol. 2017 Sep;67(3):543-548. doi: 10.1016/j.jhep.2017.04.020. Epub 2017 May 5.



Fontana RJ, Engle RE, Purcell RH, Lee WM; ALFSG.

Hepatology. 2017 Jan;65(1):389-390. doi: 10.1002/hep.28794. Epub 2016 Oct 6. No abstract available.


The role of hepatitis E virus infection in adult Americans with acute liver failure.

Fontana RJ, Engle RE, Scaglione S, Araya V, Shaikh O, Tillman H, Attar N, Purcell RH, Lee WM; US Acute Liver Failure Study Group.

Hepatology. 2016 Dec;64(6):1870-1880. doi: 10.1002/hep.28649. Epub 2016 Jun 23.


Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway.

Latham Birt SH, Purcell R, Botham KM, Wheeler-Jones CP.

J Lipid Res. 2016 Jul;57(7):1204-18. doi: 10.1194/jlr.M067108. Epub 2016 May 16.


The Association of Cytokines and Micronutrients with Hepatitis E Virus Infection During Pregnancy and the Postpartum Period in Rural Bangladesh.

Kmush BL, Labrique A, Li W, Klein SL, Schulze K, Shaikh S, Ali H, Engle RE, Wu L, Purcell RH, Mehra S, Christian P, West K Jr, Nelson K.

Am J Trop Med Hyg. 2016 Jan;94(1):203-11. doi: 10.4269/ajtmh.15-0238. Epub 2015 Nov 30.


An Epidemiologic Investigation of a Case of Acute Hepatitis E.

Sarkar S, Rivera EM, Engle RE, Nguyen HT, Schechterly CA, Alter HJ, Liang TJ, Purcell RH, Hoofnagle JH, Ghany MG.

J Clin Microbiol. 2015 Nov;53(11):3547-52. doi: 10.1128/JCM.01189-15. Epub 2015 Sep 2.


Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge.

Bukh J, Engle RE, Faulk K, Wang RY, Farci P, Alter HJ, Purcell RH.

J Virol. 2015 Sep;89(17):9128-32. doi: 10.1128/JVI.01194-15. Epub 2015 Jun 17.


Bacillus anthracis Capsular Conjugates Elicit Chimpanzee Polyclonal Antibodies That Protect Mice from Pulmonary Anthrax.

Chen Z, Schneerson R, Lovchik JA, Dai Z, Kubler-Kielb J, Agulto L, Leppla SH, Purcell RH.

Clin Vaccine Immunol. 2015 Aug;22(8):902-8. doi: 10.1128/CVI.00137-15. Epub 2015 Jun 3.


Declining prevalence of hepatitis E antibodies among Danish blood donors.

Holm DK, Moessner BK, Engle RE, Zaaijer HL, Georgsen J, Purcell RH, Christensen PB.

Transfusion. 2015 Jul;55(7):1662-7. doi: 10.1111/trf.13028. Epub 2015 Mar 27.


A single chimpanzee-human neutralizing monoclonal antibody provides post-exposure protection against type 1 and type 2 polioviruses.

Kouiavskaia D, Chen Z, Dragunsky E, Mirochnitchenko O, Purcell R, Chumakov K.

J Clin Virol. 2015 Apr;65:32-7. doi: 10.1016/j.jcv.2015.01.023. Epub 2015 Feb 3.


A thin layer angiogenesis assay: a modified basement matrix assay for assessment of endothelial cell differentiation.

Faulkner A, Purcell R, Hibbert A, Latham S, Thomson S, Hall WL, Wheeler-Jones C, Bishop-Bailey D.

BMC Cell Biol. 2014 Dec 5;15:41. doi: 10.1186/s12860-014-0041-5.


Complete genome sequence of a rat hepatitis e virus strain isolated in the United States.

Debing Y, Emerson SU, Purcell RH, Neyts J, Dallmeier K.

Genome Announc. 2014 Nov 6;2(6). pii: e01096-14. doi: 10.1128/genomeA.01096-14.



Purcell RH.

Natl Med J India. 2013 Nov-Dec;26(6):378-9. No abstract available.


Hepatitis E virus seroprevalence in the United States: no easy answers.

Kuniholm MH, Engle RE, Purcell RH, Nelson KE.

Hepatology. 2015 Apr;61(4):1441-2. doi: 10.1002/hep.27286. Epub 2014 Oct 24. No abstract available.


Hepatitis E virus seroprevalence in the National Health and Nutrition Examination Survey: facts trump opinion.

Engle RE, Kuniholm MH, Nelson KE, Purcell RH.

Hepatology. 2015 Apr;61(4):1442. doi: 10.1002/hep.27292. Epub 2015 Feb 27. No abstract available.


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