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Items: 1 to 20 of 24

1.

Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation.

May JN, Golombek SK, Baues M, Dasgupta A, Drude N, Rix A, Rommel D, von Stillfried S, Appold L, Pola R, Pechar M, van Bloois L, Storm G, Kuehne AJC, Gremse F, Theek B, Kiessling F, Lammers T.

Theranostics. 2020 Jan 12;10(4):1948-1959. doi: 10.7150/thno.41161. eCollection 2020.

2.

Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length.

Böhmová E, Pola R, Pechar M, Parnica J, Machová D, Janoušková O, Etrych T.

Pharmaceutics. 2020 Jan 10;12(1). pii: E59. doi: 10.3390/pharmaceutics12010059.

3.

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors.

Pola R, Böhmová E, Filipová M, Pechar M, Pankrác J, Větvička D, Olejár T, Kabešová M, Poučková P, Šefc L, Zábrodský M, Janoušková O, Bouček J, Etrych T.

Pharmaceutics. 2020 Jan 1;12(1). pii: E31. doi: 10.3390/pharmaceutics12010031.

4.

Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery.

Kunjachan S, Kotb S, Pola R, Pechar M, Kumar R, Singh B, Gremse F, Taleeli R, Trichard F, Motto-Ros V, Sancey L, Detappe A, Yasmin-Karim S, Protti A, Shanmugam I, Ireland T, Etrych T, Sridhar S, Tillement O, Makrigiorgos M, Berbeco RI.

Sci Rep. 2019 Nov 1;9(1):15844. doi: 10.1038/s41598-019-50538-w.

5.

Liver fibrosis affects the targeting properties of drug delivery systems to macrophage subsets in vivo.

Ergen C, Niemietz PM, Heymann F, Baues M, Gremse F, Pola R, van Bloois L, Storm G, Kiessling F, Trautwein C, Luedde T, Lammers T, Tacke F.

Biomaterials. 2019 Jun;206:49-60. doi: 10.1016/j.biomaterials.2019.03.025. Epub 2019 Mar 22.

PMID:
30925288
6.

Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells.

Pola R, Král V, Filippov SK, Kaberov L, Etrych T, Sieglová I, Sedláček J, Fábry M, Pechar M.

Biomacromolecules. 2019 Jan 14;20(1):412-421. doi: 10.1021/acs.biomac.8b01616. Epub 2018 Dec 7.

PMID:
30485077
7.

Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors.

Theek B, Baues M, Gremse F, Pola R, Pechar M, Negwer I, Koynov K, Weber B, Barz M, Jahnen-Dechent W, Storm G, Kiessling F, Lammers T.

J Control Release. 2018 Jul 28;282:25-34. doi: 10.1016/j.jconrel.2018.05.002. Epub 2018 May 4.

8.

Polymer Cancerostatics Targeted with an Antibody Fragment Bound via a Coiled Coil Motif: In Vivo Therapeutic Efficacy against Murine BCL1 Leukemia.

Pechar M, Pola R, Janoušková O, Sieglová I, Král V, Fábry M, Tomalová B, Kovář M.

Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700173. Epub 2017 Sep 15.

PMID:
28921867
9.

Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles.

Ergen C, Heymann F, Al Rawashdeh W, Gremse F, Bartneck M, Panzer U, Pola R, Pechar M, Storm G, Mohr N, Barz M, Zentel R, Kiessling F, Trautwein C, Lammers T, Tacke F.

Biomaterials. 2017 Jan;114:106-120. doi: 10.1016/j.biomaterials.2016.11.009. Epub 2016 Nov 9.

PMID:
27855336
10.

Passive Tumor Targeting of Polymer Therapeutics: In Vivo Imaging of Both the Polymer Carrier and the Enzymatically Cleavable Drug Model.

Pola R, Heinrich AK, Mueller T, Kostka L, Mäder K, Pechar M, Etrych T.

Macromol Biosci. 2016 Nov;16(11):1577-1582. doi: 10.1002/mabi.201600273. Epub 2016 Sep 22.

PMID:
27654467
11.

The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia.

Tomalova B, Sirova M, Rossmann P, Pola R, Strohalm J, Chytil P, Cerny V, Tomala J, Kabesova M, Rihova B, Ulbrich K, Etrych T, Kovar M.

J Control Release. 2016 Feb 10;223:1-10. doi: 10.1016/j.jconrel.2015.12.023. Epub 2015 Dec 18.

PMID:
26708020
12.

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity.

Lynn GM, Laga R, Darrah PA, Ishizuka AS, Balaci AJ, Dulcey AE, Pechar M, Pola R, Gerner MY, Yamamoto A, Buechler CR, Quinn KM, Smelkinson MG, Vanek O, Cawood R, Hills T, Vasalatiy O, Kastenmüller K, Francica JR, Stutts L, Tom JK, Ryu KA, Esser-Kahn AP, Etrych T, Fisher KD, Seymour LW, Seder RA.

Nat Biotechnol. 2015 Nov;33(11):1201-10. doi: 10.1038/nbt.3371. Epub 2015 Oct 26.

13.

Thermoresponsive Polymer Micelles as Potential Nanosized Cancerostatics.

Laga R, Janoušková O, Ulbrich K, Pola R, Blažková J, Filippov SK, Etrych T, Pechar M.

Biomacromolecules. 2015 Aug 10;16(8):2493-505. doi: 10.1021/acs.biomac.5b00764. Epub 2015 Jul 16.

PMID:
26153904
14.

Coiled coil peptides and polymer-peptide conjugates: synthesis, self-assembly, characterization and potential in drug delivery systems.

Pechar M, Pola R, Laga R, Braunová A, Filippov SK, Bogomolova A, Bednárová L, Vaněk O, Ulbrich K.

Biomacromolecules. 2014 Jul 14;15(7):2590-9. doi: 10.1021/bm500436p. Epub 2014 Jun 3.

PMID:
24857680
15.

Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging.

Theek B, Gremse F, Kunjachan S, Fokong S, Pola R, Pechar M, Deckers R, Storm G, Ehling J, Kiessling F, Lammers T.

J Control Release. 2014 May 28;182:83-9. doi: 10.1016/j.jconrel.2014.03.007. Epub 2014 Mar 12.

16.

Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines.

Kunjachan S, Pola R, Gremse F, Theek B, Ehling J, Moeckel D, Hermanns-Sachweh B, Pechar M, Ulbrich K, Hennink WE, Storm G, Lederle W, Kiessling F, Lammers T.

Nano Lett. 2014 Feb 12;14(2):972-81. doi: 10.1021/nl404391r. Epub 2014 Jan 17.

17.

Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia.

Pola R, Laga R, Ulbrich K, Sieglová I, Král V, Fábry M, Kabešová M, Kovář M, Pechar M.

Biomacromolecules. 2013 Mar 11;14(3):881-9. doi: 10.1021/bm3019592. Epub 2013 Feb 14.

PMID:
23373696
18.

Polymer carriers for anticancer drugs targeted to EGF receptor.

Studenovsky M, Pola R, Pechar M, Etrych T, Ulbrich K, Kovar L, Kabesova M, Rihova B.

Macromol Biosci. 2012 Dec;12(12):1714-20. doi: 10.1002/mabi.201200270. Epub 2012 Oct 17.

PMID:
23077133
19.

Noninvasive optical imaging of nanomedicine biodistribution.

Kunjachan S, Gremse F, Theek B, Koczera P, Pola R, Pechar M, Etrych T, Ulbrich K, Storm G, Kiessling F, Lammers T.

ACS Nano. 2013 Jan 22;7(1):252-62. doi: 10.1021/nn303955n. Epub 2012 Oct 24.

20.

The coiled coil motif in polymer drug delivery systems.

Pechar M, Pola R.

Biotechnol Adv. 2013 Jan-Feb;31(1):90-6. doi: 10.1016/j.biotechadv.2012.01.003. Epub 2012 Jan 12. Review.

PMID:
22266376

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