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Items: 17

1.

Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.

Turnaturi R, Montenegro L, Marrazzo A, Parenti R, Pasquinucci L, Parenti C.

Eur J Med Chem. 2018 Jul 15;155:492-502. doi: 10.1016/j.ejmech.2018.06.017. Epub 2018 Jun 7. Review.

PMID:
29908442
2.

Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives.

Pasquinucci L, Parenti C, Amata E, Georgoussi Z, Pallaki P, Camarda V, Calò G, Arena E, Montenegro L, Turnaturi R.

Pharmaceuticals (Basel). 2018 May 5;11(2). pii: E40. doi: 10.3390/ph11020040.

3.

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.

Turnaturi R, Parenti C, Prezzavento O, Marrazzo A, Pallaki P, Georgoussi Z, Amata E, Pasquinucci L.

Molecules. 2018 Mar 16;23(3). pii: E677. doi: 10.3390/molecules23030677.

4.

In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations.

Montenegro L, Turnaturi R, Parenti C, Pasquinucci L.

Pharmaceutics. 2018 Feb 27;10(1). pii: E27. doi: 10.3390/pharmaceutics10010027.

5.

Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review.

Turnaturi R, Marrazzo A, Parenti C, Pasquinucci L.

Eur J Med Chem. 2018 Mar 25;148:410-422. doi: 10.1016/j.ejmech.2018.02.046. Epub 2018 Feb 17. Review.

PMID:
29477074
6.

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy.

Montenegro L, Turnaturi R, Parenti C, Pasquinucci L.

Nanomaterials (Basel). 2018 Feb 5;8(2). pii: E87. doi: 10.3390/nano8020087. Review.

7.

Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.

Montenegro L, Parenti C, Turnaturi R, Pasquinucci L.

Pharmaceutics. 2017 Dec 10;9(4). pii: E58. doi: 10.3390/pharmaceutics9040058.

8.

Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles.

Montenegro L, Pasquinucci L, Zappalà A, Chiechio S, Turnaturi R, Parenti C.

Pharmaceutics. 2017 Oct 21;9(4). pii: E48. doi: 10.3390/pharmaceutics9040048.

9.

Development of novel LP1-based analogues with enhanced delta opioid receptor profile.

Pasquinucci L, Turnaturi R, Prezzavento O, Arena E, Aricò G, Georgoussi Z, Parenti R, Cantarella G, Parenti C.

Bioorg Med Chem. 2017 Sep 1;25(17):4745-4752. doi: 10.1016/j.bmc.2017.07.021. Epub 2017 Jul 11.

PMID:
28734666
10.

Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management.

Turnaturi R, Arico G, Ronsisvalle G, Pasquinucci L, Parenti C.

Curr Med Chem. 2016;23(40):4506-4528. Review.

PMID:
27781944
11.

Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect.

Vicario N, Parenti R, Arico' G, Turnaturi R, Scoto GM, Chiechio S, Parenti C.

Mol Pain. 2016 Sep 2;12. pii: 1744806916667949. doi: 10.1177/1744806916667949. Print 2016. No abstract available.

12.

Evaluation of N-substituent structural variations in opioid receptor profile of LP1.

Pasquinucci L, Turnaturi R, Aricò G, Parenti C, Pallaki P, Georgoussi Z, Ronsisvalle S.

Bioorg Med Chem. 2016 Jun 15;24(12):2832-42. doi: 10.1016/j.bmc.2016.05.005. Epub 2016 May 5.

PMID:
27234885
13.

Multitarget opioid ligands in pain relief: New players in an old game.

Turnaturi R, Aricò G, Ronsisvalle G, Parenti C, Pasquinucci L.

Eur J Med Chem. 2016 Jan 27;108:211-228. doi: 10.1016/j.ejmech.2015.11.028. Epub 2015 Nov 22. Review.

PMID:
26656913
14.

Differential scanning calorimetry approach to investigate the transfer of the multitarget opioid analgesic LP1 to biomembrane model.

Accolla ML, Turnaturi R, Sarpietro MG, Ronsisvalle S, Castelli F, Pasquinucci L.

Eur J Med Chem. 2014 Apr 22;77:84-90. doi: 10.1016/j.ejmech.2014.02.056. Epub 2014 Feb 25.

PMID:
24631726
15.

The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures.

Parenti C, Turnaturi R, Aricò G, Gramowski-Voss A, Schroeder OH, Marrazzo A, Prezzavento O, Ronsisvalle S, Scoto GM, Ronsisvalle G, Pasquinucci L.

Neuropharmacology. 2013 Aug;71:70-82. doi: 10.1016/j.neuropharm.2013.03.008. Epub 2013 Mar 27.

PMID:
23541722
16.

Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand.

Parenti C, Turnaturi R, Aricò G, Marrazzo A, Prezzavento O, Ronsisvalle S, Scoto GM, Ronsisvalle G, Pasquinucci L.

Life Sci. 2012 Jun 27;90(25-26):957-61. doi: 10.1016/j.lfs.2012.04.041. Epub 2012 May 11.

PMID:
22580287
17.

The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment.

Pasquinucci L, Parenti C, Turnaturi R, Aricò G, Marrazzo A, Prezzavento O, Ronsisvalle S, Georgoussi Z, Fourla DD, Scoto GM, Ronsisvalle G.

Life Sci. 2012 Jan 2;90(1-2):66-70. doi: 10.1016/j.lfs.2011.10.024. Epub 2011 Nov 9.

PMID:
22100511

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