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Items: 1 to 20 of 41

1.

Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19.

Conti I, Morigi R, Locatelli A, Rambaldi M, Bua G, Gallinella G, Leoni A.

Molecules. 2019 Mar 15;24(6). pii: E1037. doi: 10.3390/molecules24061037.

2.

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.

Morigi R, Locatelli A, Leoni A, Rambaldi M, Bortolozzi R, Mattiuzzo E, Ronca R, Maccarinelli F, Hamel E, Bai R, Brancale A, Viola G.

Eur J Med Chem. 2019 Mar 15;166:514-530. doi: 10.1016/j.ejmech.2019.01.049. Epub 2019 Jan 26.

PMID:
30784885
3.

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells.

De Magis A, Manzo SG, Russo M, Marinello J, Morigi R, Sordet O, Capranico G.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):816-825. doi: 10.1073/pnas.1810409116. Epub 2018 Dec 27.

4.

Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora.

Morigi R, Vitali B, Prata C, Palomino RAN, Graziadio A, Locatelli A, Rambaldi M, Leoni A.

Med Chem. 2018;14(3):311-319. doi: 10.2174/1573406413666171010110819.

PMID:
29032761
5.

1,4-Anthraquinone: A new useful pre-column reagent for the determination of N-acetylcysteine and captopril in pharmaceuticals by high performance liquid chromatography.

Gatti R, Morigi R.

J Pharm Biomed Anal. 2017 Sep 5;143:299-304. doi: 10.1016/j.jpba.2017.06.011. Epub 2017 Jun 15.

PMID:
28633061
6.

Small-Molecules Targeting Kinases Involved in Pulmonary Hypertension: a Patent Review (2010-2015).

Morigi R, Rambaldi M, Locatelli A, Leoni A.

Curr Med Chem. 2016;23(30):3510-3527. Review.

PMID:
27516199
7.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Amato J, Morigi R, Pagano B, Pagano A, Ohnmacht S, De Magis A, Tiang YP, Capranico G, Locatelli A, Graziadio A, Leoni A, Rambaldi M, Novellino E, Neidle S, Randazzo A.

J Med Chem. 2016 Jun 23;59(12):5706-20. doi: 10.1021/acs.jmedchem.6b00129. Epub 2016 Jun 6.

PMID:
27223049
8.

2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2016;26(2):149-73. doi: 10.1517/13543776.2016.1118059. Epub 2015 Dec 4. Review.

PMID:
26561198
9.

Recent Patents on Thiazole Derivatives Endowed with Antitumor Activity.

Morigi R, Locatelli A, Leoni A, Rambaldi M.

Recent Pat Anticancer Drug Discov. 2015;10(3):280-97. Review.

PMID:
26152151
10.

Synthesis and antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives.

Kumar S, Gopalakrishnan V, Hegde M, Rana V, Dhepe SS, Ramareddy SA, Leoni A, Locatelli A, Morigi R, Rambaldi M, Srivastava M, Raghavan SC, Karki SS.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4682-4688. doi: 10.1016/j.bmcl.2014.08.032. Epub 2014 Aug 26.

PMID:
25205189
11.

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex.

Amato J, Iaccarino N, Pagano B, Morigi R, Locatelli A, Leoni A, Rambaldi M, Zizza P, Biroccio A, Novellino E, Randazzo A.

Front Chem. 2014 Jul 24;2:54. doi: 10.3389/fchem.2014.00054. eCollection 2014.

12.

Substituted E-3-(3-indolylmethylene)1,3-dihydroindol-2-ones with antiproliferative activity. Study of the effects on HL-60 leukemia cells.

Leoni A, Locatelli A, Morigi R, Rambaldi M, Cappadone C, Farruggia G, Iotti S, Merolle L, Zini M, Stefanelli C.

Eur J Med Chem. 2014 May 22;79:382-90. doi: 10.1016/j.ejmech.2014.04.004. Epub 2014 Apr 3.

PMID:
24747749
13.

Novel thiazole derivatives: a patent review (2008 - 2012. Part 2).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2014 Jul;24(7):759-77. doi: 10.1517/13543776.2014.910196. Epub 2014 Apr 19. Review.

PMID:
24745553
14.

Novel thiazole derivatives: a patent review (2008 - 2012; Part 1).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2014 Feb;24(2):201-16. doi: 10.1517/13543776.2014.858121. Epub 2013 Nov 12. Review.

PMID:
24215328
15.

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.

Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Cervellati R, Greco E, Kondratyuk TP, Park EJ, Huang K, van Breemen RB, Pezzuto JM.

Eur J Med Chem. 2013 Oct;68:412-21. doi: 10.1016/j.ejmech.2013.07.052. Epub 2013 Aug 13.

PMID:
23994869
16.

Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action.

Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Vieceli Dalla Sega F, Prata C, Nguyen TL, Bai R, Hamel E.

Eur J Med Chem. 2013 Jun;64:603-12. doi: 10.1016/j.ejmech.2013.03.033. Epub 2013 Apr 3.

17.

Intracellular magnesium content decreases during mitochondria-mediated apoptosis induced by a new indole-derivative in human colon cancer cells.

Cappadone C, Merolle L, Marraccini C, Farruggia G, Sargenti A, Locatelli A, Morigi R, Iotti S.

Magnes Res. 2012 Jul-Sep;25(3):104-11. doi: 10.1684/mrh.2012.0319.

18.

Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Farruggia G, Stefanelli C, Masotti L, Nguyen TL, Hamel E, Shoemaker RH.

J Med Chem. 2012 Mar 8;55(5):2078-88. doi: 10.1021/jm2012694. Epub 2012 Feb 15.

19.

Diclofenac salts, part 7: are the pharmaceutical salts with aliphatic amines stable?

Fini A, Cavallari C, Bassini G, Ospitali F, Morigi R.

J Pharm Sci. 2012 Sep;101(9):3157-68. doi: 10.1002/jps.23052. Epub 2012 Jan 10.

PMID:
22234897
20.

Determination of octopamine and tyramine traces in dietary supplements and phytoextracts by high performance liquid chromatography after derivatization with 2,5-dimethyl-1H-pyrrole-3,4-dicarbaldehyde.

Gatti R, Lotti C, Morigi R, Andreani A.

J Chromatogr A. 2012 Jan 13;1220:92-100. doi: 10.1016/j.chroma.2011.11.060. Epub 2011 Dec 7.

PMID:
22196247

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