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Diseases. 2018 Mar 8;6(1). pii: E19. doi: 10.3390/diseases6010019.

Hyper-Uricemia and Gouty Access in the Adult Population of the Southeast of Gabon: Biochemical Aspects.

Author information

1
Laboratory of Research in Biochemistry (LAREBIO), University of Sciences and Technology of Masuku, Franceville P.O. Box 943, Gabon. ndong_atome@yahoo.com.
2
Laboratory of Research in Biochemistry (LAREBIO), University of Sciences and Technology of Masuku, Franceville P.O. Box 943, Gabon. ngouamartel@gmail.com.
3
Laboratory of Research in Biochemistry (LAREBIO), University of Sciences and Technology of Masuku, Franceville P.O. Box 943, Gabon. cedricsima@gmail.com.
4
International Medical Research Center of Franceville (CIRMF), Franceville P.O. Box 769, Gabon. onangar@yahoo.com.
5
International Medical Research Center of Franceville (CIRMF), Franceville P.O. Box 769, Gabon. dnkoghe@hotmail.com.
6
Ministry of Public Health of Gabon, Libreville BP 50, Gabon. dnkoghe@hotmail.com.

Abstract

Gout is caused by a chronic hyperuricemia whose complications are not currently well evaluated in Africa. The aim of this study was to determine the prevalence and risk factors of hyperuricemia and gout in 85 patients recruited. A total of 26 cases of hyperuricemia, i.e., 30.6% of the study population, with 12 cases of gout and seven cases of gouty access. In this population, hyperuricemia was proportional to age (p-value < 10-4, OR = 2.6), but it was more prevalent in men, 23.5% versus 7.1% for women (p-value = 0.0047). In addition, none of these women showed signs of a gouty affection. Consumption of alcohol (OR = 13) and nucleoprotein-rich foods, obesity (BMI 30 kg/m²; OR = 6), family history of gout (OR = 6.8), as well as diseases such as high blood pressure (associated with taking diuretics; OR = 1.7), renal insufficiency (OR = 4.4) and diabetes (p < 0.049) were the main factors of the diseases associated with gout and hyperuricemia in this population. The biochemical role of these factors may increase and/or decrease the processes of synthesis and/or elimination of uric acid by acting on metabolites involved in the regulation of urate production.

KEYWORDS:

gout access; hyperuricemia; metabolism; risk factor; uric acid

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