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Items: 1 to 20 of 249

1.

Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.

Chen Y, Aurell CJ, Pettersen A, Lewis RJ, Hayes MA, Lepistö M, Jonson AC, Leek H, Thunberg L.

ACS Med Chem Lett. 2017 May 1;8(6):672-677. doi: 10.1021/acsmedchemlett.7b00137. eCollection 2017 Jun 8.

PMID:
28626531
2.

Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1.

McArthur JR, Motin L, Gleeson EC, Spiller S, Lewis RJ, Duggan PJ, Tuck KL, Adams DJ.

Br J Pharmacol. 2017 Jun 13. doi: 10.1111/bph.13910. [Epub ahead of print]

PMID:
28608537
3.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

4.

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 May 24. doi: 10.1111/bph.13865. [Epub ahead of print]

PMID:
28542706
5.

The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome.

Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN.

Biochem J. 2017 Jun 13;474(13):2145-2158. doi: 10.1042/BCJ20170256.

PMID:
28512204
6.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD.

Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0.

7.

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors.

Windley MJ, Vetter I, Lewis RJ, Nicholson GM.

Neuropharmacology. 2017 Apr 8. pii: S0028-3908(17)30149-1. doi: 10.1016/j.neuropharm.2017.04.008. [Epub ahead of print]

PMID:
28396143
8.

The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography.

Åsberg D, Langborg Weinmann A, Leek T, Lewis RJ, Klarqvist M, Leśko M, Kaczmarski K, Samuelsson J, Fornstedt T.

J Chromatogr A. 2017 May 5;1496:80-91. doi: 10.1016/j.chroma.2017.03.041. Epub 2017 Mar 21.

PMID:
28363419
9.

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor.

Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ.

Sci Rep. 2017 Mar 31;7:45466. doi: 10.1038/srep45466.

10.

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M.

PLoS One. 2017 Mar 16;12(3):e0173551. doi: 10.1371/journal.pone.0173551. eCollection 2017.

11.

Structure and Function of the Stressosome Signalling Hub.

Pané-Farré J, Quin MB, Lewis RJ, Marles-Wright J.

Subcell Biochem. 2017;83:1-41. doi: 10.1007/978-3-319-46503-6_1.

PMID:
28271471
12.

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, Vetter I.

Sci Rep. 2017 Feb 22;7:42810. doi: 10.1038/srep42810.

13.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883.

14.

The GpsB files: the truth is out there.

Lewis RJ.

Mol Microbiol. 2017 Mar;103(6):913-918. doi: 10.1111/mmi.13612. Epub 2017 Jan 12.

PMID:
28010044
15.

Regulation of bacterial cell wall growth.

Egan AJ, Cleverley RM, Peters K, Lewis RJ, Vollmer W.

FEBS J. 2017 Mar;284(6):851-867. doi: 10.1111/febs.13959. Epub 2016 Nov 23. Review.

PMID:
27862967
16.

Structural and conformational determinants of macrocycle cell permeability.

Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD 4th, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MW, Duvall JR, Kihlberg J.

Nat Chem Biol. 2016 Dec;12(12):1065-1074. doi: 10.1038/nchembio.2203. Epub 2016 Oct 17.

PMID:
27748751
17.

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.

Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJ, Zimmermann K, Reeh PW.

Pain. 2016 Nov;157(11):2504-2516.

PMID:
27434506
18.

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.

Yin K, Deuis JR, Lewis RJ, Vetter I.

Mol Pain. 2016 Aug 28;12. pii: 1744806916665366. doi: 10.1177/1744806916665366. Print 2016.

19.

Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay.

Lewis RJ, Inserra M, Vetter I, Holland WC, Hardison DR, Tester PA, Litaker RW.

PLoS One. 2016 Jul 28;11(7):e0160006. doi: 10.1371/journal.pone.0160006. eCollection 2016.

20.

The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli.

Peters K, Kannan S, Rao VA, Biboy J, Vollmer D, Erickson SW, Lewis RJ, Young KD, Vollmer W.

MBio. 2016 Jun 21;7(3). pii: e00819-16. doi: 10.1128/mBio.00819-16.

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