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Items: 1 to 20 of 255

1.

Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment.

Morgan M, Deuis JR, Frøsig-Jørgensen M, Lewis RJ, Cabot PJ, Gray PD, Vetter I.

Pain Med. 2017 Sep 23. doi: 10.1093/pm/pnx228. [Epub ahead of print]

PMID:
29036469
2.

Conotoxin Φ-MiXXVIIA from the new superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity.

Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2017 Oct 5. doi: 10.1002/anie.201708927. [Epub ahead of print]

PMID:
28984021
3.

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.

4.

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1.

Touska F, Sattler S, Malsch P, Lewis RJ, Reeh PW, Zimmermann K.

Mar Drugs. 2017 Aug 30;15(9). pii: E269. doi: 10.3390/md15090269.

5.

Erratum: Structural and conformational determinants of macrocycle cell permeability.

Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD 4th, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MWD, Duvall JR, Kihlberg J.

Nat Chem Biol. 2017 Jul 18;13(8):922. doi: 10.1038/nchembio0817-922a. No abstract available.

PMID:
28853740
6.

Sodium channels and pain: from toxins to therapies.

Cardoso FC, Lewis RJ.

Br J Pharmacol. 2017 Jul 27. doi: 10.1111/bph.13962. [Epub ahead of print] Review.

PMID:
28749537
7.

Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.

Chen Y, Aurell CJ, Pettersen A, Lewis RJ, Hayes MA, Lepistö M, Jonson AC, Leek H, Thunberg L.

ACS Med Chem Lett. 2017 May 1;8(6):672-677. doi: 10.1021/acsmedchemlett.7b00137. eCollection 2017 Jun 8.

PMID:
28626531
8.

Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1.

McArthur JR, Motin L, Gleeson EC, Spiller S, Lewis RJ, Duggan PJ, Tuck KL, Adams DJ.

Br J Pharmacol. 2017 Jun 13. doi: 10.1111/bph.13910. [Epub ahead of print]

PMID:
28608537
9.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

10.

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.

PMID:
28542706
11.

The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome.

Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN.

Biochem J. 2017 Jun 13;474(13):2145-2158. doi: 10.1042/BCJ20170256.

12.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD.

Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0.

13.

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors.

Windley MJ, Vetter I, Lewis RJ, Nicholson GM.

Neuropharmacology. 2017 Apr 8. pii: S0028-3908(17)30149-1. doi: 10.1016/j.neuropharm.2017.04.008. [Epub ahead of print]

PMID:
28396143
14.

The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography.

Åsberg D, Langborg Weinmann A, Leek T, Lewis RJ, Klarqvist M, Leśko M, Kaczmarski K, Samuelsson J, Fornstedt T.

J Chromatogr A. 2017 May 5;1496:80-91. doi: 10.1016/j.chroma.2017.03.041. Epub 2017 Mar 21.

PMID:
28363419
15.

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor.

Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ.

Sci Rep. 2017 Mar 31;7:45466. doi: 10.1038/srep45466.

16.

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M.

PLoS One. 2017 Mar 16;12(3):e0173551. doi: 10.1371/journal.pone.0173551. eCollection 2017.

17.

Structure and Function of the Stressosome Signalling Hub.

Pané-Farré J, Quin MB, Lewis RJ, Marles-Wright J.

Subcell Biochem. 2017;83:1-41. doi: 10.1007/978-3-319-46503-6_1.

PMID:
28271471
18.

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, Vetter I.

Sci Rep. 2017 Feb 22;7:42810. doi: 10.1038/srep42810.

19.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.

20.

The GpsB files: the truth is out there.

Lewis RJ.

Mol Microbiol. 2017 Mar;103(6):913-918. doi: 10.1111/mmi.13612. Epub 2017 Jan 12.

PMID:
28010044

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