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Items: 1 to 20 of 99

1.

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes.

Booth HDE, Wessely F, Connor-Robson N, Rinaldi F, Vowles J, Browne C, Evetts SG, Hu MT, Cowley SA, Webber C, Wade-Martins R.

Neurobiol Dis. 2019 May 11;129:56-66. doi: 10.1016/j.nbd.2019.05.006. [Epub ahead of print]

2.

LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function.

Wallings R, Connor-Robson N, Wade-Martins R.

Hum Mol Genet. 2019 Apr 30. pii: ddz088. doi: 10.1093/hmg/ddz088. [Epub ahead of print]

PMID:
31039583
3.

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.

Connor-Robson N, Booth H, Martin JG, Gao B, Li K, Doig N, Vowles J, Browne C, Klinger L, Juhasz P, Klein C, Cowley SA, Bolam P, Hirst W, Wade-Martins R.

Neurobiol Dis. 2019 Apr 5;127:512-526. doi: 10.1016/j.nbd.2019.04.005. [Epub ahead of print]

PMID:
30954703
4.

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA, Wade-Martins R.

Hum Mol Genet. 2019 Jun 15;28(12):2001-2013. doi: 10.1093/hmg/ddz038.

5.

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.

Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, Hu MT, Cowley SA, Webber C, Wade-Martins R.

Cell Stem Cell. 2019 Jan 3;24(1):93-106.e6. doi: 10.1016/j.stem.2018.10.023. Epub 2018 Nov 29.

6.

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells.

Smith AM, Depp C, Ryan BJ, Johnston GI, Alegre-Abarrategui J, Evetts S, Rolinski M, Baig F, Ruffmann C, Simon AK, Hu MTM, Wade-Martins R.

Mov Disord. 2018 Oct;33(10):1580-1590. doi: 10.1002/mds.104. Epub 2018 Oct 7.

7.

Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.

Gordon D, Dafinca R, Scaber J, Alegre-Abarrategui J, Farrimond L, Scott C, Biggs D, Kent L, Oliver PL, Davies B, Ansorge O, Wade-Martins R, Talbot K.

Neurobiol Dis. 2019 Jan;121:148-162. doi: 10.1016/j.nbd.2018.09.024. Epub 2018 Oct 2.

PMID:
30290270
8.

Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD.

Arora S, Baig F, Lo C, Barber TR, Lawton MA, Zhan A, Rolinski M, Ruffmann C, Klein JC, Rumbold J, Louvel A, Zaiwalla Z, Lennox G, Quinnell T, Dennis G, Wade-Martins R, Ben-Shlomo Y, Little MA, Hu MT.

Neurology. 2018 Oct 16;91(16):e1528-e1538. doi: 10.1212/WNL.0000000000006366. Epub 2018 Sep 19.

9.

Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury.

Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ.

Metabolites. 2018 Sep 7;8(3). pii: E50. doi: 10.3390/metabo8030050.

10.

Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.

Finelli MJ, Paramo T, Pires E, Ryan BJ, Wade-Martins R, Biggin PC, McCullagh J, Oliver PL.

Mol Neurobiol. 2019 Mar;56(3):1558-1577. doi: 10.1007/s12035-018-1174-x. Epub 2018 Jun 15.

11.

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.

Lai MC, Bechy AL, Denk F, Collins E, Gavriliouk M, Zaugg JB, Ryan BJ, Wade-Martins R, Caffrey TM.

Mol Neurodegener. 2017 Oct 30;12(1):79. doi: 10.1186/s13024-017-0224-6.

12.

Are rodent models of Parkinson's disease behaving as they should?

Vingill S, Connor-Robson N, Wade-Martins R.

Behav Brain Res. 2018 Oct 15;352:133-141. doi: 10.1016/j.bbr.2017.10.021. Epub 2017 Oct 24. Review.

PMID:
29074404
13.

Convergent pathways in Parkinson's disease.

Cherubini M, Wade-Martins R.

Cell Tissue Res. 2018 Jul;373(1):79-90. doi: 10.1007/s00441-017-2700-2. Epub 2017 Oct 23. Review.

14.

Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.

McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA.

Mol Ther. 2017 Oct 4;25(10):2404-2414. doi: 10.1016/j.ymthe.2017.08.017. Epub 2017 Aug 31.

15.

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.

Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, Houlden H, Gwinn K, Wray S, Luk KC, Wade-Martins R, James WS, Cowley SA.

Sci Rep. 2017 Aug 21;7(1):9003. doi: 10.1038/s41598-017-09362-3.

16.

Alpha-synuclein oligomers: a new hope.

Bengoa-Vergniory N, Roberts RF, Wade-Martins R, Alegre-Abarrategui J.

Acta Neuropathol. 2017 Dec;134(6):819-838. doi: 10.1007/s00401-017-1755-1. Epub 2017 Aug 12. Review.

17.

Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.

Doucet M, El-Turabi A, Zabel F, Hunn BHM, Bengoa-Vergniory N, Cioroch M, Ramm M, Smith AM, Gomes AC, Cabral de Miranda G, Wade-Martins R, Bachmann MF.

PLoS One. 2017 Aug 10;12(8):e0181844. doi: 10.1371/journal.pone.0181844. eCollection 2017.

18.

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.

Beevers JE, Lai MC, Collins E, Booth HDE, Zambon F, Parkkinen L, Vowles J, Cowley SA, Wade-Martins R, Caffrey TM.

Stem Cell Reports. 2017 Aug 8;9(2):587-599. doi: 10.1016/j.stemcr.2017.06.005. Epub 2017 Jul 6.

19.

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C, Antel JP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA.

Stem Cell Reports. 2017 Jun 6;8(6):1727-1742. doi: 10.1016/j.stemcr.2017.05.017.

20.

The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis.

Booth HDE, Hirst WD, Wade-Martins R.

Trends Neurosci. 2017 Jun;40(6):358-370. doi: 10.1016/j.tins.2017.04.001. Epub 2017 May 17. Review.

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