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The Unfolded Protein Response in Breast Cancer.

McGrath EP, Logue SE, Mnich K, Deegan S, Jäger R, Gorman AM, Samali A.

Cancers (Basel). 2018 Sep 21;10(10). pii: E344. doi: 10.3390/cancers10100344. Review.


Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.

Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jäger R, Gorman AM, Samali A.

Nat Commun. 2018 Aug 15;9(1):3267. doi: 10.1038/s41467-018-05763-8.


Methods for studying ER stress and UPR markers in human cells.

Kennedy D, Samali A, Jäger R.

Methods Mol Biol. 2015;1292:3-18. doi: 10.1007/978-1-4939-2522-3_1.


Regulation of apoptosis by heat shock proteins.

Kennedy D, Jäger R, Mosser DD, Samali A.

IUBMB Life. 2014 May;66(5):327-38. doi: 10.1002/iub.1274. Epub 2014 May 26. Review.


New roles for old enzymes: killer caspases as the engine of cell behavior changes.

Connolly PF, Jäger R, Fearnhead HO.

Front Physiol. 2014 Apr 16;5:149. doi: 10.3389/fphys.2014.00149. eCollection 2014. Review.


Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma.

Vincenz L, Jäger R, O'Dwyer M, Samali A.

Mol Cancer Ther. 2013 Jun;12(6):831-43. doi: 10.1158/1535-7163.MCT-12-0782. Epub 2013 May 31. Review.


"Dead Cells Talking": The Silent Form of Cell Death Is Not so Quiet.

Jäger R, Fearnhead HO.

Biochem Res Int. 2012;2012:453838. doi: 10.1155/2012/453838. Epub 2012 Aug 7.


Stress management at the ER: regulators of ER stress-induced apoptosis.

Gorman AM, Healy SJ, Jäger R, Samali A.

Pharmacol Ther. 2012 Jun;134(3):306-16. doi: 10.1016/j.pharmthera.2012.02.003. Epub 2012 Feb 17. Review.


The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.

Jäger R, Bertrand MJ, Gorman AM, Vandenabeele P, Samali A.

Biol Cell. 2012 May;104(5):259-70. doi: 10.1111/boc.201100055. Epub 2012 Feb 29. Review.


Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes.

Jäger R, Pappas L, Schorle H.

BMC Res Notes. 2011 Sep 9;4:345. doi: 10.1186/1756-0500-4-345. No abstract available.


Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells.

Thewes V, Orso F, Jäger R, Eckert D, Schäfer S, Kirfel G, Garbe S, Taverna D, Schorle H.

BMC Cancer. 2010 May 11;10:192. doi: 10.1186/1471-2407-10-192.


Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland.

Jäger R, Schäfer S, Hau-Liersch M, Schorle H.

Dev Dyn. 2010 Mar;239(3):1027-33. doi: 10.1002/dvdy.22239.


The enigmatic roles of caspases in tumor development.

Jäger R, Zwacka RM.

Cancers (Basel). 2010 Nov 24;2(4):1952-79. doi: 10.3390/cancers2041952.


AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase.

Orso F, Jäger R, Calogero RA, Schorle H, Sismondi P, De Bortoli M, Taverna D.

BMC Biol. 2009 May 22;7:25. doi: 10.1186/1741-7007-7-25.


An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system.

Kurth P, Moenning A, Jäger R, Beine G, Schorle H.

Dev Dyn. 2009 May;238(5):1064-72. doi: 10.1002/dvdy.21939.


Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway.

Moenning A, Jäger R, Egert A, Kress W, Wardelmann E, Schorle H.

Mol Cell Biol. 2009 Feb;29(3):881-91. doi: 10.1128/MCB.00885-08. Epub 2008 Dec 1.


Suprabasal BCL-2 expression does not sensitize to chemically-induced skin cancer in transgenic mice.

Schenkel J, Weiher H, Fürstenberger G, Jäger R.

Anticancer Res. 2008 Sep-Oct;28(5A):2825-9.


Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes.

Jäger R, Pappas L, Schorle H.

BMC Res Notes. 2008 Jun 23;1:29. doi: 10.1186/1756-0500-1-29.


Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells.

Peitz M, Jäger R, Patsch C, Jäger A, Egert A, Schorle H, Edenhofer F.

Genesis. 2007 Aug;45(8):508-17.


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