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Items: 1 to 20 of 35


Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells.

Gnanasekaran KK, Pouland T, Bunce RA, Darrell Berlin K, Abuskhuna S, Bhandari D, Mashayekhi M, Zhou DH, Benbrook DM.

Bioorg Med Chem. 2020 Jan 1;28(1):115244. doi: 10.1016/j.bmc.2019.115244. Epub 2019 Dec 2.


4H-Benzo[d][1,3]oxazin-4-ones and Dihydro Analogs from Substituted Anthranilic Acids and Orthoesters.

Annor-Gyamfi JK, Bunce RA.

Molecules. 2019 Oct 1;24(19). pii: E3555. doi: 10.3390/molecules24193555.


Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity.

Punchi Hewage AND, Yao H, Nammalwar B, Gnanasekaran KK, Lovell S, Bunce RA, Eshelman K, Phaniraj SM, Lee MM, Peterson BR, Battaile KP, Reitz AB, Rivera M.

J Am Chem Soc. 2019 May 22;141(20):8171-8184. doi: 10.1021/jacs.9b00394. Epub 2019 May 9.


Synthesis and biological evaluation of SHetA2 (NSC-721689) analogs against the ovarian cancer cell line A2780.

Nammalwar B, Bunce RA, Berlin KD, Benbrook DM, Toal C.

Eur J Med Chem. 2019 May 15;170:16-27. doi: 10.1016/j.ejmech.2019.03.010. Epub 2019 Mar 7.



Gnanasekaran KK, Rivera M, Bunce RA.

Org Prep Proced Int. 2018;50(3):372-374. doi: 10.1080/00304948.2018.1462072. Epub 2018 May 17. No abstract available.


Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters.

Gavin JT, Annor-Gyamfi JK, Bunce RA.

Molecules. 2018 Nov 9;23(11). pii: E2925. doi: 10.3390/molecules23112925.


Activity of oxygen-versus sulfur-containing analogs of the Flex-Het anticancer agent SHetA2.

Watts FM Jr, Pouland T, Bunce RA, Berlin KD, Benbrook DM, Mashayekhi M, Bhandari D, Zhou D.

Eur J Med Chem. 2018 Oct 5;158:720-732. doi: 10.1016/j.ejmech.2018.09.036. Epub 2018 Sep 14.


Syntheses of 1-Aryl-5-nitro-1H-indazoles and a General One-Pot Route to 1-Aryl-1H-indazoles.

Annor-Gyamfi JK, Gnanasekaran KK, Bunce RA.

Molecules. 2018 Mar 16;23(3). pii: E674. doi: 10.3390/molecules23030674.


OSU-6: A Highly Efficient, Metal-Free, Heterogeneous Catalyst for the Click Synthesis of 5-Benzyl and 5-Aryl-1H-tetrazoles.

Nammalwar B, Muddala NP, Pitchimani R, Bunce RA.

Molecules. 2015 Dec 19;20(12):22757-66. doi: 10.3390/molecules201219881.


Direct Synthesis of Thioethers from Carboxylates and Thiols Catalyzed by FeCl3.

Venkatesham K, Bhujanga Rao C, Dokuburra CB, Bunce RA, Venkateswarlu Y.

J Org Chem. 2015 Nov 20;80(22):11611-7. doi: 10.1021/acs.joc.5b02143. Epub 2015 Oct 30.


Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex.

Muddala NP, Nammalwar B, Selvaraju S, Bourne CR, Henry M, Bunce RA, Berlin KD, Barrow EW, Barrow WW.

Molecules. 2015 Apr 21;20(4):7222-44. doi: 10.3390/molecules20047222.


Synthesis and evaluation of second generation Flex-Het scaffolds against the human ovarian cancer A2780 cell line.

Gnanasekaran KK, Benbrook DM, Nammalwar B, Thavathiru E, Bunce RA, Berlin KD.

Eur J Med Chem. 2015;96:209-17. doi: 10.1016/j.ejmech.2015.03.070. Epub 2015 Apr 4.


Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis.

Nammalwar B, Bourne CR, Wakeham N, Bourne PC, Barrow EW, Muddala NP, Bunce RA, Berlin KD, Barrow WW.

Bioorg Med Chem. 2015 Jan 1;23(1):203-11. doi: 10.1016/j.bmc.2014.11.009. Epub 2014 Nov 11.


Isolation, structural assignment and synthesis of (SE)-2-methyloctyl 3-(4-methoxyphenyl) propenoate from the marine soft coral Sarcophyton ehrenbergi.

Bhujanga Rao C, Babu DC, Bharadwaj TV, Srikanth D, Vardhan KS, Raju TV, Bunce RA, Venkateswarlu Y.

Nat Prod Res. 2015;29(1):70-6. doi: 10.1080/14786419.2014.958742. Epub 2014 Sep 17.


Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis.

Nammalwar B, Muddala NP, Bourne CR, Henry M, Bourne PC, Bunce RA, Barrow EW, Berlin KD, Barrow WW.

Molecules. 2014 Mar 17;19(3):3231-46. doi: 10.3390/molecules19033231.


The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking.

Bourne CR, Wakeham N, Webb N, Nammalwar B, Bunce RA, Berlin KD, Barrow WW.

Biochemistry. 2014 Feb 25;53(7):1228-38. doi: 10.1021/bi401104t. Epub 2014 Feb 11.


Recent syntheses of 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4(1H)-quinolinones and 4(1H)-quinolinones using domino reactions.

Nammalwar B, Bunce RA.

Molecules. 2013 Dec 24;19(1):204-32. doi: 10.3390/molecules19010204. Review.


SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres.

Benbrook DM, Nammalwar B, Long A, Matsumoto H, Singh A, Bunce RA, Berlin KD.

Invest New Drugs. 2014 Jun;32(3):412-23. doi: 10.1007/s10637-013-0041-x. Epub 2013 Nov 20.


Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics.

Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW.

Org Prep Proced Int. 2013;45(1):66-71. No abstract available.


1-Alkyl- and (±)-1,2-dialkyl-2,3-dihydro-1,8-naphthyridin-4(1H)-ones by a tandem Michael-SNAr annulation reaction.

Bunce RA, Squires ST, Nammalwar B.

J Org Chem. 2013 Mar 1;78(5):2144-8. doi: 10.1021/jo3018632. Epub 2012 Nov 12.


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