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Items: 1 to 20 of 66

1.

Increased MMP activity in curved geometries disrupts the endothelial cell glycocalyx creating a proinflammatory environment.

Cooper S, Emmott A, McDonald KK, Campeau MA, Leask RL.

PLoS One. 2018 Aug 23;13(8):e0202526. doi: 10.1371/journal.pone.0202526. eCollection 2018.

2.

Transesophageal echocardiographic strain imaging predicts aortic biomechanics: Beyond diameter.

Emmott A, Alzahrani H, Alreshidan M, Therrien J, Leask RL, Lachapelle K.

J Thorac Cardiovasc Surg. 2018 Aug;156(2):503-512.e1. doi: 10.1016/j.jtcvs.2018.01.107. Epub 2018 Mar 11.

PMID:
29627182
3.

3D printing materials and their use in medical education: a review of current technology and trends for the future.

Garcia J, Yang Z, Mongrain R, Leask RL, Lachapelle K.

BMJ Simul Technol Enhanc Learn. 2018 Jan;4(1):27-40. doi: 10.1136/bmjstel-2017-000234. Epub 2017 Oct 21.

4.

Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms.

Shahmansouri N, Alreshidan M, Emmott A, Lachapelle K, El-Hamamsy I, Cartier R, Leask RL, Mongrain R.

Materials (Basel). 2016 Oct 26;9(11). pii: E867. doi: 10.3390/ma9110867.

5.

Histopathological and biomechanical properties of the aortic wall in 2 patients with chronic type A aortic dissection.

Emmott A, El-Hamamsy I, Leask RL.

Cardiovasc Pathol. 2017 Jul - Aug;29:48-52. doi: 10.1016/j.carpath.2017.05.006. Epub 2017 May 30.

PMID:
28601673
6.

Stenosis Hemodynamics Disrupt the Endothelial Cell Glycocalyx by MMP Activity Creating a Proinflammatory Environment.

Cooper S, McDonald K, Burkat D, Leask RL.

Ann Biomed Eng. 2017 Sep;45(9):2234-2243. doi: 10.1007/s10439-017-1846-0. Epub 2017 May 4.

PMID:
28474270
7.

Blood flow can signal during angiogenesis not only through mechanotransduction, but also by affecting growth factor distribution.

Ghaffari S, Leask RL, Jones EAV.

Angiogenesis. 2017 Aug;20(3):373-384. doi: 10.1007/s10456-017-9553-x. Epub 2017 Apr 3.

PMID:
28374123
8.

Obtaining the biomechanical behavior of ascending aortic aneurysm via the use of novel speckle tracking echocardiography.

Alreshidan M, Shahmansouri N, Chung J, Lash V, Emmott A, Leask RL, Lachapelle K.

J Thorac Cardiovasc Surg. 2017 Apr;153(4):781-788. doi: 10.1016/j.jtcvs.2016.11.056. Epub 2016 Dec 20.

PMID:
28094007
9.

Glycocalyx Degradation Induces a Proinflammatory Phenotype and Increased Leukocyte Adhesion in Cultured Endothelial Cells under Flow.

McDonald KK, Cooper S, Danielzak L, Leask RL.

PLoS One. 2016 Dec 1;11(12):e0167576. doi: 10.1371/journal.pone.0167576. eCollection 2016.

10.

Loss of mechanical directional dependency of the ascending aorta with severe medial degeneration.

Chung J, Lachapelle K, Cartier R, Mongrain R, Leask RL.

Cardiovasc Pathol. 2017 Jan - Feb;26:45-50. doi: 10.1016/j.carpath.2016.11.001. Epub 2016 Nov 15.

PMID:
27888778
11.

Evaluating ascending aortic aneurysm tissue toughness: Dependence on collagen and elastin contents.

Shahmansouri N, Alreshidan M, Emmott A, Lachapelle K, Cartier R, Leask RL, Mongrain R.

J Mech Behav Biomed Mater. 2016 Dec;64:262-71. doi: 10.1016/j.jmbbm.2016.08.006. Epub 2016 Aug 6.

PMID:
27526037
12.

Effect of in vivo flow dynamics on angiogenesis by computational modeling.

Ghaffari S, Leask RL, Jones EA.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:961-4. doi: 10.1109/EMBC.2015.7318523.

PMID:
26736423
13.

Biomechanics of the Ascending Thoracic Aorta: A Clinical Perspective on Engineering Data.

Emmott A, Garcia J, Chung J, Lachapelle K, El-Hamamsy I, Mongrain R, Cartier R, Leask RL.

Can J Cardiol. 2016 Jan;32(1):35-47. doi: 10.1016/j.cjca.2015.10.015. Epub 2015 Oct 23. Review.

PMID:
26724509
14.

Flow dynamics control the location of sprouting and direct elongation during developmental angiogenesis.

Ghaffari S, Leask RL, Jones EA.

Development. 2015 Dec 1;142(23):4151-7. doi: 10.1242/dev.128058. Epub 2015 Nov 9.

15.

Making it stick: the role of structural design in implantable technologies.

Lee W, Leask RL, Moraes C.

Integr Biol (Camb). 2015 Nov;7(11):1335-8. doi: 10.1039/c5ib90041g.

PMID:
26446511
16.

Simultaneous imaging of blood flow dynamics and vascular remodelling during development.

Ghaffari S, Leask RL, Jones EA.

Development. 2015 Dec 1;142(23):4158-67. doi: 10.1242/dev.127019. Epub 2015 Oct 6.

17.

The effect of simvastatin treatment on endothelial cell response to shear stress and tumor necrosis factor alpha stimulation.

Dick M, MacDonald K, Tardif JC, Leask RL.

Biomed Eng Online. 2015 Jun 20;14:58. doi: 10.1186/s12938-015-0057-x.

18.

Designing greener plasticizers: Effects of alkyl chain length and branching on the biodegradation of maleate based plasticizers.

Erythropel HC, Brown T, Maric M, Nicell JA, Cooper DG, Leask RL.

Chemosphere. 2015 Sep;134:106-12. doi: 10.1016/j.chemosphere.2015.04.014. Epub 2015 Apr 27.

PMID:
25917507
19.

Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure.

Erythropel HC, Maric M, Nicell JA, Leask RL, Yargeau V.

Appl Microbiol Biotechnol. 2014 Dec;98(24):9967-81. doi: 10.1007/s00253-014-6183-8. Epub 2014 Nov 7. Review.

PMID:
25376446
20.

Energy loss, a novel biomechanical parameter, correlates with aortic aneurysm size and histopathologic findings.

Chung J, Lachapelle K, Wener E, Cartier R, De Varennes B, Fraser R, Leask RL.

J Thorac Cardiovasc Surg. 2014 Sep;148(3):1082-8; discussion 1088-9. doi: 10.1016/j.jtcvs.2014.06.021. Epub 2014 Jun 13.

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