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Items: 1 to 20 of 61

1.

ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation.

Marano D, Fioriniello S, Fiorillo F, Gibbons RJ, D'Esposito M, Della Ragione F.

Int J Mol Sci. 2019 Oct 29;20(21). pii: E5371. doi: 10.3390/ijms20215371.

2.

Persistence of skewed X-chromosome inactivation in pre-B acute lymphoblastic leukemia of a female ATRX mutation carrier.

Bradley CP, Chen C, Oetjen KA, Yan C, Panjwani R, Hauffe S, Calvo KR, Yuan C, Patel PA, Montgomery ND, Foster MC, Battiwalla M, Barrett AJ, Gibbons RJ, Ito S.

Blood Adv. 2019 Sep 10;3(17):2627-2631. doi: 10.1182/bloodadvances.2019000013. No abstract available.

3.

Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors.

Moir-Meyer G, Cheong PL, Olijnik AA, Brown J, Knight S, King A, Kurita R, Nakamura Y, Gibbons RJ, Higgs DR, Buckle VJ, Babbs C.

Methods Protoc. 2018 Jul 30;1(3). pii: E28. doi: 10.3390/mps1030028.

4.

The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening.

Kim J, Sun C, Tran AD, Chin PJ, Ruiz PD, Wang K, Gibbons RJ, Gamble MJ, Liu Y, Oberdoerffer P.

Nat Struct Mol Biol. 2019 Mar;26(3):213-219. doi: 10.1038/s41594-019-0192-3. Epub 2019 Mar 4.

5.

Refining the Primrose syndrome phenotype: A study of five patients with ZBTB20 de novo variants and a review of the literature.

Cleaver R, Berg J, Craft E, Foster A, Gibbons RJ, Hobson E, Lachlan K, Naik S, Sampson JR, Sharif S, Smithson S; Deciphering Developmental Disorders Study, Parker MJ, Tatton-Brown K.

Am J Med Genet A. 2019 Mar;179(3):344-349. doi: 10.1002/ajmg.a.61024. Epub 2019 Jan 13.

PMID:
30637921
6.

How to Tackle Challenging ChIP-Seq, with Long-Range Cross-Linking, Using ATRX as an Example.

Truch J, Telenius J, Higgs DR, Gibbons RJ.

Methods Mol Biol. 2018;1832:105-130. doi: 10.1007/978-1-4939-8663-7_6.

PMID:
30073524
7.

Mutant IDH1 Promotes Glioma Formation In Vivo.

Philip B, Yu DX, Silvis MR, Shin CH, Robinson JP, Robinson GL, Welker AE, Angel SN, Tripp SR, Sonnen JA, VanBrocklin MW, Gibbons RJ, Looper RE, Colman H, Holmen SL.

Cell Rep. 2018 May 1;23(5):1553-1564. doi: 10.1016/j.celrep.2018.03.133.

8.

Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays.

Mettananda S, Clark K, Fisher CA, Sloane-Stanley JA, Gibbons RJ, Higgs DR.

Exp Hematol. 2018 Apr;60:10-20. doi: 10.1016/j.exphem.2018.01.001. Epub 2018 Jan 9.

PMID:
29329925
9.

2 new cases of pontocerebellar hypoplasia type 10 identified by whole exome sequencing in a Turkish family.

Wafik M, Taylor J, Lester T, Gibbons RJ, Shears DJ.

Eur J Med Genet. 2018 May;61(5):273-279. doi: 10.1016/j.ejmg.2018.01.002. Epub 2018 Jan 4.

PMID:
29307788
10.

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.

Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR.

Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7.

11.

The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats.

Nguyen DT, Voon HPJ, Xella B, Scott C, Clynes D, Babbs C, Ayyub H, Kerry J, Sharpe JA, Sloane-Stanley JA, Butler S, Fisher CA, Gray NE, Jenuwein T, Higgs DR, Gibbons RJ.

EMBO Rep. 2017 Jun;18(6):914-928. doi: 10.15252/embr.201643078. Epub 2017 May 9.

12.

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.

Mettananda S, Fisher CA, Sloane-Stanley JA, Taylor S, Oppermann U, Gibbons RJ, Higgs DR.

Haematologica. 2017 Mar;102(3):e80-e84. doi: 10.3324/haematol.2016.155655. Epub 2016 Nov 3. No abstract available.

13.

Genetic dissection of the α-globin super-enhancer in vivo.

Hay D, Hughes JR, Babbs C, Davies JOJ, Graham BJ, Hanssen L, Kassouf MT, Marieke Oudelaar AM, Sharpe JA, Suciu MC, Telenius J, Williams R, Rode C, Li PS, Pennacchio LA, Sloane-Stanley JA, Ayyub H, Butler S, Sauka-Spengler T, Gibbons RJ, Smith AJH, Wood WG, Higgs DR.

Nat Genet. 2016 Aug;48(8):895-903. doi: 10.1038/ng.3605. Epub 2016 Jul 4.

14.

Maintaining memory of silencing at imprinted differentially methylated regions.

Voon HP, Gibbons RJ.

Cell Mol Life Sci. 2016 May;73(9):1871-9. doi: 10.1007/s00018-016-2157-6. Epub 2016 Feb 16. Review.

15.

Understanding α-globin gene regulation and implications for the treatment of β-thalassemia.

Mettananda S, Gibbons RJ, Higgs DR.

Ann N Y Acad Sci. 2016 Mar;1368(1):16-24. doi: 10.1111/nyas.12988. Epub 2015 Dec 22. Review.

PMID:
26695885
16.

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.

Schwab RA, Nieminuszczy J, Shah F, Langton J, Lopez Martinez D, Liang CC, Cohn MA, Gibbons RJ, Deans AJ, Niedzwiedz W.

Mol Cell. 2015 Nov 5;60(3):351-61. doi: 10.1016/j.molcel.2015.09.012. Epub 2015 Oct 22.

17.

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.

Clynes D, Jelinska C, Xella B, Ayyub H, Scott C, Mitson M, Taylor S, Higgs DR, Gibbons RJ.

Nat Commun. 2015 Jul 6;6:7538. doi: 10.1038/ncomms8538.

18.

α-Globin as a molecular target in the treatment of β-thalassemia.

Mettananda S, Gibbons RJ, Higgs DR.

Blood. 2015 Jun 11;125(24):3694-701. doi: 10.1182/blood-2015-03-633594. Epub 2015 Apr 13. Review.

19.

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.

Voon HP, Hughes JR, Rode C, De La Rosa-Velázquez IA, Jenuwein T, Feil R, Higgs DR, Gibbons RJ.

Cell Rep. 2015 Apr 21;11(3):405-18. doi: 10.1016/j.celrep.2015.03.036. Epub 2015 Apr 9.

20.

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.

Chen E, Ahn JS, Massie CE, Clynes D, Godfrey AL, Li J, Park HJ, Nangalia J, Silber Y, Mullally A, Gibbons RJ, Green AR.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15190-5. doi: 10.1073/pnas.1401873111. Epub 2014 Oct 6.

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