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Items: 1 to 20 of 21

1.

An electrochemical biosensor based on Hairpin-DNA modified gold electrode for detection of DNA damage by a hybrid cancer drug intercalation.

Lozano Untiveros K, da Silva EG, de Abreu FC, da Silva-Júnior EF, de Araújo-Junior JX, Mendoça de Aquino T, Armas SM, de Moura RO, Mendonça-Junior FJB, Serafim VL, Chumbimuni-Torres K.

Biosens Bioelectron. 2019 May 15;133:160-168. doi: 10.1016/j.bios.2019.02.071. Epub 2019 Mar 14.

PMID:
30933710
2.

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses.

Luna EC, Luna IS, Scotti L, Monteiro AFM, Scotti MT, de Moura RO, de Araújo RSA, Monteiro KLC, de Aquino TM, Ribeiro FF, Mendonça FJB.

Oxid Med Cell Longev. 2019 Feb 7;2019:6587150. doi: 10.1155/2019/6587150. eCollection 2019. Review.

3.

Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives.

Gouveia RG, Ribeiro AG, Segundo MÂSP, de Oliveira JF, de Lima MDCA, de Lima Souza TRC, de Almeida SMV, de Moura RO.

Bioorg Med Chem. 2018 Dec 1;26(22):5911-5921. doi: 10.1016/j.bmc.2018.10.038. Epub 2018 Oct 29.

PMID:
30420325
4.

Spiro-acridine inhibiting tyrosinase enzyme: Kinetic, protein-ligand interaction and molecular docking studies.

Menezes TM, de Almeida SMV, de Moura RO, Seabra G, de Lima MDCA, Neves JL.

Int J Biol Macromol. 2019 Feb 1;122:289-297. doi: 10.1016/j.ijbiomac.2018.10.175. Epub 2018 Oct 26.

PMID:
30401647
5.

SB-83, a 2-Amino-thiophene derivative orally bioavailable candidate for the leishmaniasis treatment.

Rodrigues KADF, Silva DKF, Serafim VL, Andrade PN, Alves AF, Tafuri WL, Batista TM, Mangueira VM, Sobral MV, Moura RO, Mendonça Junior FJB, Oliveira MR.

Biomed Pharmacother. 2018 Dec;108:1670-1678. doi: 10.1016/j.biopha.2018.10.012. Epub 2018 Oct 11.

6.

Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.

Moraes ADTO, Miranda MDS, Jacob ÍTT, Amorim CADC, Moura RO, Silva SÂSD, Soares MBP, Almeida SMV, Souza TRCL, Oliveira JF, Silva TGD, Melo CML, Moreira DRM, Lima MDCA.

Bioorg Med Chem. 2018 Nov 1;26(20):5388-5396. doi: 10.1016/j.bmc.2018.07.024. Epub 2018 Jul 17.

PMID:
30293795
7.

Effect of antiprotozoal molecules on hypnospores of Perkinsus spp. parasite.

Duarte SS, de Moura RO, da Silva PM.

Exp Parasitol. 2018 Sep;192:25-35. doi: 10.1016/j.exppara.2018.07.004. Epub 2018 Jul 17.

PMID:
30028986
8.

New thiophene-acridine compounds: Synthesis, antileishmanial activity, DNA binding, chemometric, and molecular docking studies.

de Lima Serafim V, Félix MB, Frade Silva DK, Rodrigues KADF, Andrade PN, de Almeida SMV, de Albuquerque Dos Santos S, de Oliveira JF, de Lima MDCA, Mendonça-Junior FJB, Scotti MT, de Oliveira MR, de Moura RO.

Chem Biol Drug Des. 2018 Jun;91(6):1141-1155. doi: 10.1111/cbdd.13176. Epub 2018 Mar 25.

PMID:
29415325
9.

Genetic Mechanisms of Antibiotic Resistance and the Role of Antibiotic Adjuvants.

Pontes DS, de Araujo RSA, Dantas N, Scotti L, Scotti MT, de Moura RO, Mendonca-Junior FJB.

Curr Top Med Chem. 2018;18(1):42-74. doi: 10.2174/1568026618666180206095224. Review.

PMID:
29412107
10.

Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities.

Lafayette EA, de Almeida SMV, Cavalcanti Santos RV, de Oliveira JF, Amorim CADC, da Silva RMF, Pitta MGDR, Pitta IDR, de Moura RO, de Carvalho Júnior LB, de Melo Rêgo MJB, de Lima MDCA.

Eur J Med Chem. 2017 Aug 18;136:511-522. doi: 10.1016/j.ejmech.2017.05.012. Epub 2017 May 4.

PMID:
28531811
11.

Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay.

de Oliveira JF, Lima TS, Vendramini-Costa DB, de Lacerda Pedrosa SCB, Lafayette EA, da Silva RMF, de Almeida SMV, de Moura RO, Ruiz ALTG, de Carvalho JE, de Lima MDCA.

Eur J Med Chem. 2017 Aug 18;136:305-314. doi: 10.1016/j.ejmech.2017.05.023. Epub 2017 May 8.

PMID:
28505535
12.

A new acridine derivative induces cell cycle arrest and antiangiogenic effect on Ehrlich ascites carcinoma model.

Mangueira VM, Batista TM, Brito MT, Sousa TKG, Cruz RMDD, Abrantes RA, Veras RC, Medeiros IA, Medeiros KKP, Pereira ALDC, Serafim VL, Moura RO, Sobral MV.

Biomed Pharmacother. 2017 Jun;90:253-261. doi: 10.1016/j.biopha.2017.03.049. Epub 2017 Mar 30.

PMID:
28364597
13.

Hybrid Compounds as Direct Multitarget Ligands: A Review.

de Oliveira Pedrosa M, Duarte da Cruz RM, de Oliveira Viana J, de Moura RO, Ishiki HM, Barbosa Filho JM, Diniz MF, Scotti MT, Scotti L, Bezerra Mendonca FJ.

Curr Top Med Chem. 2017;17(9):1044-1079. doi: 10.2174/1568026616666160927160620. Review.

PMID:
27697048
14.

New spiro-acridines: DNA interaction, antiproliferative activity and inhibition of human DNA topoisomerases.

Almeida SM, Lafayette EA, Silva WL, Lima Serafim V, Menezes TM, Neves JL, Ruiz AL, Carvalho JE, Moura RO, Beltrão EI, Carvalho Júnior LB, Lima MD.

Int J Biol Macromol. 2016 Nov;92:467-475. doi: 10.1016/j.ijbiomac.2016.07.057. Epub 2016 Jul 18.

PMID:
27435006
15.

Evaluation of anti-inflammatory effect of derivative (E)-N-(4-bromophenyl)-2-(thiophen-2-ylmethylene)-thiosemicarbazone.

de Oliveira JF, Nonato FR, Zafred RRT, Leite NMS, Ruiz ALTG, de Carvalho JE, da Silva AL, de Moura RO, Alves de Lima MDC.

Biomed Pharmacother. 2016 May;80:388-392. doi: 10.1016/j.biopha.2016.03.047. Epub 2016 Apr 9.

PMID:
27133079
16.

Antimitotic activity of the pyrimidinone derivative py-09 on sea urchin embryonic development.

Macedo D, Mendonça Júnior FJ, de Moura RO, Marques-Santos LF.

Toxicol In Vitro. 2016 Mar;31:72-85. doi: 10.1016/j.tiv.2015.11.015. Epub 2015 Nov 23.

PMID:
26616279
17.

2-Amino-thiophene derivatives present antileishmanial activity mediated by apoptosis and immunomodulation in vitro.

Rodrigues KA, Dias CN, Néris PL, Rocha Jda C, Scotti MT, Scotti L, Mascarenhas SR, Veras RC, de Medeiros IA, Keesen Tde S, de Oliveira TB, de Lima Mdo C, Balliano TL, de Aquino TM, de Moura RO, Mendonça Junior FJ, de Oliveira MR.

Eur J Med Chem. 2015 Dec 1;106:1-14. doi: 10.1016/j.ejmech.2015.10.011. Epub 2015 Oct 17.

PMID:
26513640
18.

Synthesis of thiophene-thiosemicarbazone derivatives and evaluation of their in vitro and in vivo antitumor activities.

de Oliveira JF, da Silva AL, Vendramini-Costa DB, da Cruz Amorim CA, Campos JF, Ribeiro AG, Olímpio de Moura R, Neves JL, Ruiz AL, Ernesto de Carvalho J, Alves de Lima Mdo C.

Eur J Med Chem. 2015 Nov 2;104:148-56. doi: 10.1016/j.ejmech.2015.09.036.

PMID:
26454648
19.

Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives.

de Almeida SM, Lafayette EA, da Silva LP, Amorim CA, de Oliveira TB, Ruiz AL, de Carvalho JE, de Moura RO, Beltrão EI, de Lima Mdo C, de Carvalho Júnior LB.

Int J Mol Sci. 2015 Jun 9;16(6):13023-42. doi: 10.3390/ijms160613023.

20.

Synthesis, DNA binding and topoisomerase I inhibition activity of thiazacridine and imidazacridine derivatives.

Lafayette EA, Vitalino de Almeida SM, Pitta MG, Carneiro Beltrão EI, da Silva TG, Olímpio de Moura R, Pitta Ida R, de Carvalho LB Jr, de Lima Mdo C.

Molecules. 2013 Dec 6;18(12):15035-50. doi: 10.3390/molecules181215035.

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