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Items: 1 to 20 of 65

1.

Second-generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors.

Lamut A, Skok Ž, Barančoková M, Gutierrez LJ, Cruz CD, Tammela P, Draskovits G, Szili PÉ, Nyerges Á, Pál C, Molek P, Bratkovič T, Ilaš J, Zidar N, Zega A, Enriz RD, Kikelj D, Tomašič T.

Future Med Chem. 2020 Feb;12(4):277-297. doi: 10.4155/fmc-2019-0127. Epub 2020 Feb 11.

PMID:
32043377
2.

Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors.

Vettorazzi M, Insuasty D, Lima S, Gutiérrez L, Nogueras M, Marchal A, Abonia R, Andújar S, Spiegel S, Cobo J, Enriz RD.

Bioorg Chem. 2020 Jan;94:103414. doi: 10.1016/j.bioorg.2019.103414. Epub 2019 Nov 13.

3.

Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques.

Campos LE, Garibotto FM, Angelina E, Kos J, Tomašič T, Zidar N, Kikelj D, Gonec T, Marvanova P, Mokry P, Jampilek J, Alvarez SE, Enriz RD.

Bioorg Chem. 2019 Oct;91:103125. doi: 10.1016/j.bioorg.2019.103125. Epub 2019 Jul 12.

PMID:
31401373
4.

Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect.

Bermejo A, Collado A, Barrachina I, Marqués P, El Aouad N, Franck X, Garibotto F, Dacquet C, Caignard DH, Suvire FD, Enriz RD, Piqueras L, Figadère B, Sanz MJ, Cabedo N, Cortes D.

J Nat Prod. 2019 Jul 26;82(7):1802-1812. doi: 10.1021/acs.jnatprod.9b00003. Epub 2019 Jul 3.

PMID:
31268307
5.

The nitrone spin trap 5,5‑dimethyl‑1‑pyrroline N‑oxide binds to toll-like receptor-2-TIR-BB-loop domain and dampens downstream inflammatory signaling.

Muñoz MD, Gutierrez LJ, Delignat S, Russick J, Gomez Mejiba SE, Lacroix-Desmazes S, Enriz RD, Ramirez DC.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1152-1159. doi: 10.1016/j.bbadis.2019.01.005. Epub 2019 Jan 23.

PMID:
30684639
6.

Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity.

Vettorazzi M, Vila L, Lima S, Acosta L, Yépes F, Palma A, Cobo J, Tengler J, Malik I, Alvarez S, Marqués P, Cabedo N, Sanz MJ, Jampilek J, Spiegel S, Enriz RD.

Arch Pharm (Weinheim). 2019 Mar;352(3):e1800298. doi: 10.1002/ardp.201800298. Epub 2019 Jan 16.

PMID:
30648282
7.

Antinociceptive effect of neo-clerodane diterpenes obtained from Baccharis flabellata.

Funes M, Garro MF, Tosso RD, Maria AO, Saad JR, Enriz RD.

Fitoterapia. 2018 Oct;130:94-99. doi: 10.1016/j.fitote.2018.08.017. Epub 2018 Aug 24.

PMID:
30145332
8.

Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer.

Gera J, Szögi T, Bozsó Z, Fülöp L, Barrera EE, Rodriguez AM, Méndez L, Delpiccolo CML, Mata EG, Cioffi F, Broersen K, Paragi G, Enriz RD.

Bioorg Chem. 2018 Dec;81:211-221. doi: 10.1016/j.bioorg.2018.08.018. Epub 2018 Aug 18.

PMID:
30144634
9.

Theoretical models to predict the inhibitory effect of ligands of sphingosine kinase 1 using QTAIM calculations and hydrogen bond dynamic propensity analysis.

Vettorazzi M, Menéndez C, Gutiérrez L, Andujar S, Appignanesi G, Enriz RD.

J Comput Aided Mol Des. 2018 Jul;32(7):781-791. doi: 10.1007/s10822-018-0129-7. Epub 2018 Jul 3.

PMID:
29971548
10.

The Antimicrobial Activity of Annona emarginata (Schltdl.) H. Rainer and Most Active Isolated Compounds against Clinically Important Bacteria.

Dolab JG, Lima B, Spaczynska E, Kos J, Cano NH, Feresin G, Tapia A, Garibotto F, Petenatti E, Olivella M, Musiol R, Jampilek J, Enriz RD.

Molecules. 2018 May 16;23(5). pii: E1187. doi: 10.3390/molecules23051187.

11.

Cholinesterase-inhibitory effect and in silico analysis of alkaloids from bulbs of Hieronymiella species.

Ortiz JE, Garro A, Pigni NB, Agüero MB, Roitman G, Slanis A, Enriz RD, Feresin GE, Bastida J, Tapia A.

Phytomedicine. 2018 Jan 15;39:66-74. doi: 10.1016/j.phymed.2017.12.020. Epub 2017 Dec 20.

PMID:
29433685
12.

New substituted aminopyrimidine derivatives as BACE1 inhibitors: in silico design, synthesis and biological assays.

Gutiérrez LJ, Parravicini O, Sánchez E, Rodríguez R, Cobo J, Enriz RD.

J Biomol Struct Dyn. 2019 Jan;37(1):229-246. doi: 10.1080/07391102.2018.1424036. Epub 2018 Feb 1.

PMID:
29301478
13.

Synthesis, Analysis, Cholinesterase-Inhibiting Activity and Molecular Modelling Studies of 3-(Dialkylamino)-2-hydroxypropyl 4-[(Alkoxy-carbonyl)amino]benzoates and Their Quaternary Ammonium Salts.

Padrtova T, Marvanova P, Odehnalova K, Kubinova R, Parravicini O, Garro A, Enriz RD, Humpa O, Oravec M, Mokry P.

Molecules. 2017 Nov 23;22(12). pii: E2048. doi: 10.3390/molecules22122048.

14.

Tetrahydroisoquinolines functionalized with carbamates as selective ligands of D2 dopamine receptor.

Parravicini O, Bogado ML, Rojas S, Angelina EL, Andujar SA, Gutierrez LJ, Cabedo N, Sanz MJ, López-Gresa MP, Cortes D, Enriz RD.

J Mol Model. 2017 Sep 2;23(9):273. doi: 10.1007/s00894-017-3441-6.

PMID:
28866777
15.

An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.

Vettorazzi M, Angelina E, Lima S, Gonec T, Otevrel J, Marvanova P, Padrtova T, Mokry P, Bobal P, Acosta LM, Palma A, Cobo J, Bobalova J, Csollei J, Malik I, Alvarez S, Spiegel S, Jampilek J, Enriz RD.

Eur J Med Chem. 2017 Oct 20;139:461-481. doi: 10.1016/j.ejmech.2017.08.017. Epub 2017 Aug 10.

16.

Molecular design and synthesis of novel peptides from amphibians skin acting as inhibitors of cholinesterase enzymes.

Siano A, Garibotto FF, Andujar SA, Baldoni HA, Tonarelli GG, Enriz RD.

J Pept Sci. 2017 Mar;23(3):236-244. doi: 10.1002/psc.2974. Epub 2017 Feb 2.

PMID:
28150445
17.

The Eighth Central European Conference "Chemistry towards Biology": Snapshot.

Perczel A, Atanasov AG, Sklenář V, Nováček J, Papoušková V, Kadeřávek P, Žídek L, Kozłowski H, Wątły J, Hecel A, Kołkowska P, Koča J, Svobodová-Vařeková R, Pravda L, Sehnal D, Horský V, Geidl S, Enriz RD, Matějka P, Jeništová A, Dendisová M, Kokaislová A, Weissig V, Olsen M, Coffey A, Ajuebor J, Keary R, Sanz-Gaitero M, van Raaij MJ, McAuliffe O, Waltenberger B, Mocan A, Šmejkal K, Heiss EH, Diederich M, Musioł R, Košmrlj J, Polański J, Jampílek J.

Molecules. 2016 Oct 17;21(10). pii: E1381.

18.

Dopaminergic isoquinolines with hexahydrocyclopenta[ij]-isoquinolines as D2-like selective ligands.

Párraga J, Andujar SA, Rojas S, Gutierrez LJ, El Aouad N, Sanz MJ, Enriz RD, Cabedo N, Cortes D.

Eur J Med Chem. 2016 Oct 21;122:27-42. doi: 10.1016/j.ejmech.2016.06.009. Epub 2016 Jun 10.

PMID:
27343851
19.

Alkaloids from Hippeastrum argentinum and Their Cholinesterase-Inhibitory Activities: An in Vitro and in Silico Study.

Ortiz JE, Pigni NB, Andujar SA, Roitman G, Suvire FD, Enriz RD, Tapia A, Bastida J, Feresin GE.

J Nat Prod. 2016 May 27;79(5):1241-8. doi: 10.1021/acs.jnatprod.5b00785. Epub 2016 Apr 20.

PMID:
27096334
20.

Small Peptides Derived from Penetratin as Antibacterial Agents.

Parravicini O, Somlai C, Andujar SA, Garro AD, Lima B, Tapia A, Feresin G, Perczel A, Tóth G, Cascales JL, Rodríguez AM, Enriz RD.

Arch Pharm (Weinheim). 2016 Apr;349(4):242-51. doi: 10.1002/ardp.201500419. Epub 2016 Mar 11.

PMID:
26972341

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