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Deamidation and enzymatic hydrolysis of gliadins alter their processing by dendritic cells in vitro.

Villemin C, Tranquet O, Solé V, Smit J, Pieters R, Denery S, Bouchaud G.

J Agric Food Chem. 2019 Dec 9. doi: 10.1021/acs.jafc.9b06075. [Epub ahead of print]


The Kiwifruit Allergen Act d 1 Activates NF-κB Signaling and Affects mRNA Expression of TJ Proteins and Innate Pro-Allergenic Cytokines.

Nešić A, Čavić M, Popović M, Zlatanova M, Pieters R, Smit J, Gavrović-Jankulović M.

Biomolecules. 2019 Dec 2;9(12). pii: E816. doi: 10.3390/biom9120816.


Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK.

Nat Rev Drug Discov. 2019 Nov 20. doi: 10.1038/s41573-019-0048-x. [Epub ahead of print] Review.


A network-based approach for identifying suitable biomarkers for oral immunotherapy of food allergy.

van Bilsen JHM, Verschuren L, Wagenaar L, Vonk MM, van Esch BCAM, Knippels LMJ, Garssen J, Smit JJ, Pieters RHH, van den Broek TJ.

BMC Bioinformatics. 2019 Apr 23;20(1):206. doi: 10.1186/s12859-019-2802-9.


Non-digestible oligosaccharides scFOS/lcFOS facilitate safe subcutaneous immunotherapy for peanut allergy.

Wagenaar L, van Roest M, Kruijssen LJW, Simons PJ, Boon L, Vonk MM, van Esch BCAM, Knippels LMJ, Garssen J, Pieters RHH, Smit JJ.

Clin Mol Allergy. 2019 Apr 4;17:7. doi: 10.1186/s12948-019-0111-5. eCollection 2019.


Mouse strain differences in response to oral immunotherapy for peanut allergy.

Wagenaar L, Bol-Schoenmakers MWHC, Giustarini G, Garssen J, Smit JJ, Pieters RHH.

Immun Inflamm Dis. 2019 Mar;7(1):41-51. doi: 10.1002/iid3.242. Epub 2019 Mar 5.


Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow's Milk Allergic Mice.

Vonk MM, Blokhuis BRJ, Diks MAP, Wagenaar L, Smit JJ, Pieters RHH, Garssen J, Knippels LMJ, van Esch BCAM.

Mediators Inflamm. 2019 Jan 16;2019:9062537. doi: 10.1155/2019/9062537. eCollection 2019.


Chemically modified peanut extract shows increased safety while maintaining immunogenicity.

van der Kleij HPM, Warmenhoven HJM, van Ree R, Versteeg SA, Pieters RHH, Dreskin SC, Knulst AC, van Hoffen E, Opstelten DJE, Koppelman SJ, Smit JJ.

Allergy. 2019 May;74(5):986-995. doi: 10.1111/all.13687. Epub 2018 Dec 27.


Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men.

Kartaram S, Mensink M, Teunis M, Schoen E, Witte G, Janssen Duijghuijsen L, Verschuren M, Mohrmann K, M'Rabet L, Knipping K, Wittink H, van Helvoort A, Garssen J, Witkamp R, Pieters R, van Norren K.

Clin Nutr. 2019 Oct;38(5):2251-2258. doi: 10.1016/j.clnu.2018.09.029. Epub 2018 Sep 28.


Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement.

Giustarini G, Vrisekoop N, Kruijssen L, Wagenaar L, van Staveren S, van Roest M, Bleumink R, Bol-Schoenmakers M, Weaver RJ, Koenderman L, Smit J, Pieters R.

Toxicol Sci. 2019 Feb 1;167(2):385-396. doi: 10.1093/toxsci/kfy244.


Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions-Ara h2 and Ara h6 Are Readily Bio-Accessible.

Koppelman SJ, Smits M, Tomassen M, de Jong GAH, Baumert J, Taylor SL, Witkamp R, Veldman RJ, Pieters R, Wichers H.

Nutrients. 2018 Sep 11;10(9). pii: E1281. doi: 10.3390/nu10091281.


Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model.

Wagenaar L, Bol-Schoenmakers M, Giustarini G, Vonk MM, van Esch BCAM, Knippels LMJ, Garssen J, Smit JJ, Pieters RHH.

Mol Nutr Food Res. 2018 Oct;62(20):e1800369. doi: 10.1002/mnfr.201800369. Epub 2018 Aug 31.


Glycation of the Major Milk Allergen β-Lactoglobulin Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation.

Perusko M, van Roest M, Stanic-Vucinic D, Simons PJ, Pieters RHH, Cirkovic Velickovic T, Smit JJ.

Mol Nutr Food Res. 2018 Sep;62(17):e1800341. doi: 10.1002/mnfr.201800341. Epub 2018 Jul 29.


Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways.

Villeneuve DL, Landesmann B, Allavena P, Ashley N, Bal-Price A, Corsini E, Halappanavar S, Hussell T, Laskin D, Lawrence T, Nikolic-Paterson D, Pallardy M, Paini A, Pieters R, Roth R, Tschudi-Monnet F.

Toxicol Sci. 2018 Jun 1;163(2):346-352. doi: 10.1093/toxsci/kfy047. Review.


Type 2 diabetes-related proteins derived from an in vitro model of inflamed fat tissue.

Ten Klooster JP, Sotiriou A, Boeren S, Vaessen S, Vervoort J, Pieters R.

Arch Biochem Biophys. 2018 Apr 15;644:81-92. doi: 10.1016/ Epub 2018 Mar 8.


Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice.

Giustarini G, Kruijssen L, van Roest M, Bleumink R, Weaver RJ, Bol-Schoenmakers M, Smit J, Pieters R.

J Appl Toxicol. 2018 May;38(5):753-765. doi: 10.1002/jat.3585. Epub 2018 Jan 26.


Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model: A Potential Role for Foxp3+ Regulatory T Cells.

Vonk MM, Diks MAP, Wagenaar L, Smit JJ, Pieters RHH, Garssen J, van Esch BCAM, Knippels LMJ.

Front Immunol. 2017 Sep 29;8:1230. doi: 10.3389/fimmu.2017.01230. eCollection 2017.


The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.

Vonk MM, Wagenaar L, Pieters RHH, Knippels LMJ, Willemsen LEM, Smit JJ, van Esch BCAM, Garssen J.

Clin Transl Allergy. 2017 Sep 29;7:35. doi: 10.1186/s13601-017-0170-y. eCollection 2017.


Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice.

Hammerschmidt-Kamper C, Biljes D, Merches K, Steiner I, Daldrup T, Bol-Schoenmakers M, Pieters RHH, Esser C.

PLoS One. 2017 Jun 30;12(6):e0180321. doi: 10.1371/journal.pone.0180321. eCollection 2017.


Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds.

Racz PI, Wildwater M, Rooseboom M, Kerkhof E, Pieters R, Yebra-Pimentel ES, Dirks RP, Spaink HP, Smulders C, Whale GF.

Toxicol In Vitro. 2017 Oct;44:11-16. doi: 10.1016/j.tiv.2017.06.002. Epub 2017 Jun 26.


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