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Items: 13


Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors.

Halawa AH, Eskandrani AA, Elgammal WE, Hassan SM, Hassan AH, Ebrahim HY, Mehany ABM, El-Agrody AM, Okasha RM.

Int J Mol Sci. 2019 Nov 8;20(22). pii: E5592. doi: 10.3390/ijms20225592.


First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents.

Okasha RM, Alsehli M, Ihmaid S, Althagfan SS, El-Gaby MSA, Ahmed HEA, Afifi TH.

Bioorg Chem. 2019 Nov;92:103262. doi: 10.1016/j.bioorg.2019.103262. Epub 2019 Sep 5.


Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene.

Alblewi FF, Okasha RM, Hritani ZM, Mohamed HM, El-Nassag MAA, Halawa AH, Mora A, Fouda AM, Assiri MA, Al-Dies AM, Afifi TH, El-Agrody AM.

Bioorg Chem. 2019 Jun;87:560-571. doi: 10.1016/j.bioorg.2019.03.059. Epub 2019 Mar 22.


Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis.

Alblewi FF, Okasha RM, Eskandrani AA, Afifi TH, Mohamed HM, Halawa AH, Fouda AM, Al-Dies AM, Mora A, El-Agrody AM.

Molecules. 2019 Mar 18;24(6). pii: E1060. doi: 10.3390/molecules24061060.


Design of Novel Oligomeric Mixed Ligand Complexes: Preparation, Biological Applications and the First Example of Their Nanosized Scale.

Okasha RM, Al-Shaikh NE, Aljohani FS, Naqvi A, Ismail EH.

Int J Mol Sci. 2019 Feb 10;20(3). pii: E743. doi: 10.3390/ijms20030743.


Cationic Cyclopentadienyliron Complex as a Novel and Successful Nucleating Agent on the Crystallization Behavior of the Biodegradable PHB Polymer.

El-Taweel SH, Al-Ahmadi AO, Alhaddad O, Okasha RM.

Molecules. 2018 Oct 19;23(10). pii: E2703. doi: 10.3390/molecules23102703.


Successful Green Synthesis of Gold Nanoparticles using a Corchorus olitorius Extract and Their Antiproliferative Effect in Cancer Cells.

Ismail EH, Saqer AMA, Assirey E, Naqvi A, Okasha RM.

Int J Mol Sci. 2018 Sep 3;19(9). pii: E2612. doi: 10.3390/ijms19092612.


Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

Ahmed HEA, El-Nassag MAA, Hassan AH, Okasha RM, Ihmaid S, Fouda AM, Afifi TH, Aljuhani A, El-Agrody AM.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1074-1088. doi: 10.1080/14756366.2018.1476503.


Design of Thermochromic Polynorbornene Bearing Spiropyran Chromophore Moieties: Synthesis, Thermal Behavior and Dielectric Barrier Discharge Plasma Treatment.

Ahmed SA, Okasha RM, Khairou KS, Afifi TH, Mohamed AH, Abd-El-Aziz AS.

Polymers (Basel). 2017 Nov 22;9(11). pii: E630. doi: 10.3390/polym9110630.


Structure-activity relationships and molecular docking studies of chromene and chromene based azo chromophores: A novel series of potent antimicrobial and anticancer agents.

Afifi TH, Okasha RM, Ahmed HEA, Ilaš J, Saleh T, Abd-El-Aziz AS.

EXCLI J. 2017 Jun 19;16:868-902. doi: 10.17179/excli2017-356. eCollection 2017.


Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions.

Okasha RM, Alblewi FF, Afifi TH, Naqvi A, Fouda AM, Al-Dies AM, El-Agrody AM.

Molecules. 2017 Mar 18;22(3). pii: E479. doi: 10.3390/molecules22030479.


A photochemical route to discrete, ternary metal chalcogenide clusters.

Williams M, Okasha RM, Nairn J, Twamley B, Afifi TH, Shapiro PJ.

Chem Commun (Camb). 2007 Aug 14;(30):3177-9. Epub 2007 May 25.


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