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Items: 1 to 20 of 22

1.

Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.

Sánchez-Fernández EM, García-Moreno MI, Arroba AI, Aguilar-Diosdado M, Padrón JM, García-Hernández R, Gamarro F, Fustero S, Sánchez-Aparicio JE, Masgrau L, García Fernández JM, Ortiz Mellet C.

Eur J Med Chem. 2019 Aug 8;182:111604. doi: 10.1016/j.ejmech.2019.111604. [Epub ahead of print]

PMID:
31425910
2.

Imidazo[2,1-a]isoindole scaffold as an uncharted structure active on Leishmania donovani.

Arsène S, Gómez-Pérez V, Escarcena R, Abengózar MÁ, García-Hernández R, Nácher-Vázquez M, San Feliciano A, Gamarro F, Rivas L, Olmo ED.

Eur J Med Chem. 2019 Jul 29;182:111568. doi: 10.1016/j.ejmech.2019.111568. [Epub ahead of print]

PMID:
31419778
3.

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids.

Sánchez-Fernández EM, García-Moreno MI, García-Hernández R, Padrón JM, García Fernández JM, Gamarro F, Ortiz Mellet C.

Molecules. 2019 Aug 8;24(16). pii: E2882. doi: 10.3390/molecules24162882.

4.

Towards developing meaningful MRI biomarkers of neuroinflammation.

Garcia-Hernandez R.

J Neurosci Res. 2019 Jun;97(6):643-644. doi: 10.1002/jnr.24410. Epub 2019 Mar 15. No abstract available.

PMID:
30874323
5.

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.

Klug DM, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Gomez-Pérez V, Ruiz-Pérez LM, Rojas-Barros DI, Gamarro F, González-Pacanowska D, Martínez-Martínez MS, Manzano P, Ferrins L, Caffrey CR, Navarro M, Pollastri MP.

PLoS Negl Trop Dis. 2019 Feb 8;13(2):e0007129. doi: 10.1371/journal.pntd.0007129. eCollection 2019 Feb.

6.

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs.

Rastrojo A, García-Hernández R, Vargas P, Camacho E, Corvo L, Imamura H, Dujardin JC, Castanys S, Aguado B, Gamarro F, Requena JM.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):246-264. doi: 10.1016/j.ijpddr.2018.04.002. Epub 2018 Apr 13.

7.

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.

Ponte-Sucre A, Gamarro F, Dujardin JC, Barrett MP, López-Vélez R, García-Hernández R, Pountain AW, Mwenechanya R, Papadopoulou B.

PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006052. doi: 10.1371/journal.pntd.0006052. eCollection 2017 Dec. Review.

8.

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei.

Pham T, Walden M, Butler C, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Gomez-Pérez V, García-Hernández R, Zecca H, Krakoff E, Kopec B, Ichire O, Mackenzie C, Pitot M, Ruiz LM, Gamarro F, González-Pacanowska D, Navarro M, Dounay AB.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3629-3635. doi: 10.1016/j.bmcl.2017.07.032. Epub 2017 Jul 11.

9.

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.

Gómez Pérez V, García-Hernandez R, Corpas-López V, Tomás AM, Martín-Sanchez J, Castanys S, Gamarro F.

Int J Parasitol Drugs Drug Resist. 2016 Aug;6(2):133-9. doi: 10.1016/j.ijpddr.2016.04.003. Epub 2016 Jun 4.

10.

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

Mondelaers A, Sanchez-Cañete MP, Hendrickx S, Eberhardt E, Garcia-Hernandez R, Lachaud L, Cotton J, Sanders M, Cuypers B, Imamura H, Dujardin JC, Delputte P, Cos P, Caljon G, Gamarro F, Castanys S, Maes L.

PLoS One. 2016 Apr 28;11(4):e0154101. doi: 10.1371/journal.pone.0154101. eCollection 2016.

11.

Fitness of Leishmania donovani parasites resistant to drug combinations.

García-Hernández R, Gómez-Pérez V, Castanys S, Gamarro F.

PLoS Negl Trop Dis. 2015 Apr 7;9(4):e0003704. doi: 10.1371/journal.pntd.0003704. eCollection 2015 Apr.

12.

Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.

Berg M, García-Hernández R, Cuypers B, Vanaerschot M, Manzano JI, Poveda JA, Ferragut JA, Castanys S, Dujardin JC, Gamarro F.

Antimicrob Agents Chemother. 2015 Apr;59(4):2242-55. doi: 10.1128/AAC.04231-14. Epub 2015 Feb 2.

13.

Mechanisms of action of substituted β-amino alkanols on Leishmania donovani.

Abengózar MÁ, Bustos LA, García-Hernández R, Fernández de Palencia P, Escarcena R, Castanys S, del Olmo E, Gamarro F, San Feliciano A, Rivas L.

Antimicrob Agents Chemother. 2015 Feb;59(2):1211-8. doi: 10.1128/AAC.04003-14. Epub 2014 Dec 8.

14.

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.

Gómez-Pérez V, Manzano JI, García-Hernández R, Castanys S, Gamarro F, Campos JM.

Eur J Med Chem. 2015 Jan 7;89:362-9. doi: 10.1016/j.ejmech.2014.10.040. Epub 2014 Oct 16.

PMID:
25462252
15.

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

Gómez-Pérez V, Manzano JI, García-Hernández R, Castanys S, Campos Rosa JM, Gamarro F.

Antimicrob Agents Chemother. 2014 Jul;58(7):4103-12. doi: 10.1128/AAC.02481-13. Epub 2014 May 5.

16.

Leishmania donovani develops resistance to drug combinations.

García-Hernández R, Manzano JI, Castanys S, Gamarro F.

PLoS Negl Trop Dis. 2012;6(12):e1974. doi: 10.1371/journal.pntd.0001974. Epub 2012 Dec 20.

17.

Comprehensive set of integrative plasmid vectors for copper-inducible gene expression in Myxococcus xanthus.

Gómez-Santos N, Treuner-Lange A, Moraleda-Muñoz A, García-Bravo E, García-Hernández R, Martínez-Cayuela M, Pérez J, Søgaard-Andersen L, Muñoz-Dorado J.

Appl Environ Microbiol. 2012 Apr;78(8):2515-21. doi: 10.1128/AEM.07502-11. Epub 2012 Jan 27.

18.

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania.

Manzano JI, Carvalho L, García-Hernández R, Poveda JA, Ferragut JA, Castanys S, Gamarro F.

J Antimicrob Chemother. 2011 Nov;66(11):2562-5. doi: 10.1093/jac/dkr345. Epub 2011 Aug 16.

PMID:
21846675
19.

A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania.

Campos-Salinas J, Cabello-Donayre M, García-Hernández R, Pérez-Victoria I, Castanys S, Gamarro F, Pérez-Victoria JM.

Mol Microbiol. 2011 Mar;79(6):1430-44. doi: 10.1111/j.1365-2958.2010.07531.x. Epub 2011 Jan 23.

20.

Non-reducing trisaccharide fatty acid monoesters: novel detergents in membrane biochemistry.

Pérez-Victoria I, Pérez-Victoria FJ, Roldán-Vargas S, García-Hernández R, Carvalho L, Castanys S, Gamarro F, Morales JC, Pérez-Victoria JM.

Biochim Biophys Acta. 2011 Mar;1808(3):717-26. doi: 10.1016/j.bbamem.2010.11.031. Epub 2010 Dec 3.

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