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Molecules. 2019 Feb 16;24(4). pii: E713. doi: 10.3390/molecules24040713.

Screening of Suitable Ionic Liquids as Green Solvents for Extraction of Eicosapentaenoic Acid (EPA) from Microalgae Biomass Using COSMO-RS Model.

Author information

1
Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia. shiva.rezaei.m@gmail.com.
2
Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia. mh_razif@upm.edu.my.
3
Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia. dradiah@upm.edu.my.
4
Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia. aslina@upm.edu.my.
5
Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia. wanazlina@upm.edu.my.
6
Department of Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia. ramin.khezri@gmail.com.
7
Department of Fundamental and Applied Sciences, Centre of Research in Ionic Liquids (CORIL), Universiti Teknologi Petronas, UTP, Bandar Seri Iskandar, Perak 32610, Malaysia. cecili@utp.edu.my.
8
International Institute for Halal Research and Training (INHART), International Islamic University Malaysia, Gombak, Kuala Lumpur 50728, Malaysia. amalgh@iium.edu.my.

Abstract

Omega-3 poly unsaturated fatty acids (PUFA) particularly eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have many health benefits including reducing the risk of cancer and cardiovascular disease. Recently, the use of ionic liquids (ILs) in lipid extraction from microalgae provides the potential to overcome common drawbacks, offers several other benefits. To date, very limited researches are available to focus on extracting microalgae lipid and PUFA in particular by using ILs. The objective of current work is to screen the potential ILs that can be applied in EPA extraction. In this study, fast ILs screening was performed with the help of a conductor like screening model for real solvents (COSMO-RS) and the ILs with higher capacity values for use in extraction of EPA were compared. According to the results, the highest capacity for EPA extraction among 352 screened cation/anion combinations belongs to [TMAm][SO₄]. It is expected to achieve a higher yield of EPA once applying this combination as the solvent in the process of extraction. ILs with small anions were observed to have higher capacities, as well possessing higher charge density compared to larger ones, and therefore, they are more preferable for extraction purposes. Moreover, shorter alkyl chain cations are preferred when using imidazolium-based IL, which agrees with experimental data.

KEYWORDS:

COSMO-RS; EPA extraction; extraction capacity; infinite dilution activity coefficient; ionic liquids; omega-3; screening

PMID:
30781457
PMCID:
PMC6412376
DOI:
10.3390/molecules24040713
[Indexed for MEDLINE]
Free PMC Article

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