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Items: 1 to 20 of 35


New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine Sponge Myrmekioderma sp.

Costa M, Coello L, Urbatzka R, Pérez M, Thorsteinsdottir M.

Mar Drugs. 2019 Jun 22;17(6). pii: E375. doi: 10.3390/md17060375.


Application of Bioactive Thermal Proteome Profiling to Decipher the Mechanism of Action of the Lipid Lowering 132-Hydroxy-pheophytin Isolated from a Marine Cyanobacteria.

Carrasco Del Amor A, Freitas S, Urbatzka R, Fresnedo O, Cristobal S.

Mar Drugs. 2019 Jun 21;17(6). pii: E371. doi: 10.3390/md17060371.


Identification of Cyanobacterial Strains with Potential for the Treatment of Obesity-Related Co-Morbidities by Bioactivity, Toxicity Evaluation and Metabolite Profiling.

Costa M, Rosa F, Ribeiro T, Hernandez-Bautista R, Bonaldo M, Gonçalves Silva N, Eiríksson F, Thorsteinsdóttir M, Ussar S, Urbatzka R.

Mar Drugs. 2019 May 10;17(5). pii: E280. doi: 10.3390/md17050280.


Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges.

Santos JD, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez Martinez I, Tormo JR, Martín JM, Urbatzka R, Vicente FM, Lage OM.

Front Microbiol. 2019 Apr 9;10:727. doi: 10.3389/fmicb.2019.00727. eCollection 2019.


Actinobacteria Isolated From Laminaria ochroleuca: A Source of New Bioactive Compounds.

Girão M, Ribeiro I, Ribeiro T, Azevedo IC, Pereira F, Urbatzka R, Leão PN, Carvalho MF.

Front Microbiol. 2019 Apr 9;10:683. doi: 10.3389/fmicb.2019.00683. eCollection 2019.


Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation.

Sousa ML, Preto M, Vasconcelos V, Linder S, Urbatzka R.

Front Oncol. 2019 Apr 3;9:224. doi: 10.3389/fonc.2019.00224. eCollection 2019.


Chlorophyll Derivatives from Marine Cyanobacteria with Lipid-Reducing Activities.

Freitas S, Silva NG, Sousa ML, Ribeiro T, Rosa F, Leão PN, Vasconcelos V, Reis MA, Urbatzka R.

Mar Drugs. 2019 Apr 17;17(4). pii: E229. doi: 10.3390/md17040229.


Silencing of PPARαBb mRNA in brown trout primary hepatocytes: effects on molecular and morphological targets under the influence of an estrogen and a PPARα agonist.

Madureira TV, Pinheiro I, Malhão F, Castro LFC, Rocha E, Urbatzka R.

Comp Biochem Physiol B Biochem Mol Biol. 2019 Mar;229:1-9. doi: 10.1016/j.cbpb.2018.12.001. Epub 2018 Dec 7.


GST transcriptional changes induced by a toxic Microcystis aeruginosa strain in two bivalve species during exposure and recovery phases.

Antas P, Carneiro M, Reis B, Castelo-Branco R, Azevedo J, Urbatzka R, Campos A, Vasconcelos V, Martins JC.

Ecotoxicology. 2018 Nov;27(9):1272-1280. doi: 10.1007/s10646-018-1980-y. Epub 2018 Sep 21.


Sex-steroids and hypolipidemic chemicals impacts on brown trout lipid and peroxisome signaling - Molecular, biochemical and morphological insights.

Madureira TV, Malhão F, Simões T, Pinheiro I, Lopes C, Gonçalves JF, Urbatzka R, Castro LFC, Lemos MFL, Rocha E.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Oct;212:1-17. doi: 10.1016/j.cbpc.2018.06.001. Epub 2018 Jun 7.


Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.

Urbatzka R, Freitas S, Palmeira A, Almeida T, Moreira J, Azevedo C, Afonso C, Correia-da-Silva M, Sousa E, Pinto M, Vasconcelos V.

Eur J Med Chem. 2018 May 10;151:272-284. doi: 10.1016/j.ejmech.2018.03.036. Epub 2018 Mar 23.


Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action.

Ribeiro T, Lemos F, Preto M, Azevedo J, Sousa ML, Leão PN, Campos A, Linder S, Vitorino R, Vasconcelos V, Urbatzka R.

PLoS One. 2017 Dec 7;12(12):e0188817. doi: 10.1371/journal.pone.0188817. eCollection 2017.


A New Ergosterol Analog, a New Bis-Anthraquinone and Anti-Obesity Activity of Anthraquinones from the Marine Sponge-Associated Fungus Talaromyces stipitatus KUFA 0207.

Noinart J, Buttachon S, Dethoup T, Gales L, Pereira JA, Urbatzka R, Freitas S, Lee M, Silva AMS, Pinto MMM, Vasconcelos V, Kijjoa A.

Mar Drugs. 2017 May 16;15(5). pii: E139. doi: 10.3390/md15050139.


Cross-interference of two model peroxisome proliferators in peroxisomal and estrogenic pathways in brown trout hepatocytes.

Madureira TV, Pinheiro I, Malhão F, Lopes C, Urbatzka R, Castro LFC, Rocha E.

Aquat Toxicol. 2017 Jun;187:153-162. doi: 10.1016/j.aquatox.2017.04.001. Epub 2017 Apr 6.


Genome specific PPARαB duplicates in salmonids and insights into estrogenic regulation in brown trout.

Madureira TV, Pinheiro I, de Paula Freire R, Rocha E, Castro LF, Urbatzka R.

Comp Biochem Physiol B Biochem Mol Biol. 2017 Jun;208-209:94-101. doi: 10.1016/j.cbpb.2017.04.005. Epub 2017 Apr 14.


Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells.

Freitas S, Martins R, Costa M, Leão PN, Vitorino R, Vasconcelos V, Urbatzka R.

Mar Drugs. 2016 Aug 31;14(9). pii: E158. doi: 10.3390/md14090158.


Insights into the potential of picoplanktonic marine cyanobacteria strains for cancer therapies - Cytotoxic mechanisms against the RKO colon cancer cell line.

Freitas S, Martins R, Campos A, Azevedo J, Osório H, Costa M, Barros P, Vasconcelos V, Urbatzka R.

Toxicon. 2016 Sep 1;119:140-51. doi: 10.1016/j.toxicon.2016.05.016. Epub 2016 May 27.


Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research.

Castro M, Preto M, Vasconcelos V, Urbatzka R.

Curr Top Med Chem. 2016;16(23):2577-604. Review.


Estrogenic and anti-estrogenic influences in cultured brown trout hepatocytes: Focus on the expression of some estrogen and peroxisomal related genes and linked phenotypic anchors.

Madureira TV, Malhão F, Pinheiro I, Lopes C, Ferreira N, Urbatzka R, Castro LF, Rocha E.

Aquat Toxicol. 2015 Dec;169:133-42. doi: 10.1016/j.aquatox.2015.10.010. Epub 2015 Oct 24.


Morphological and molecular effects of cortisol and ACTH on zebrafish stage I and II follicles.

Sousa ML, Figueiredo F, Pinheiro C, Silva A, Malhão F, Rocha MJ, Rocha E, Urbatzka R.

Reproduction. 2015 Nov;150(5):429-36. doi: 10.1530/REP-15-0271. Epub 2015 Aug 27.


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