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Items: 1 to 20 of 74

1.

Debenzylative cycloetherification as synthetic tool in the diastereoselective synthesis of 3,6-disubstituted hexahydro-2H-furo[3,2-b]pyrroles, PDE1 enzyme inhibitors with antiproliferative effect on melanoma cells.

Castán A, Badorrey R, Díez JA, Christoffersen CT, Rasmussen LK, Kehler J, Köhler R, Galvez JA, Diaz-De-Villegas MD.

J Org Chem. 2020 Apr 6. doi: 10.1021/acs.joc.0c00276. [Epub ahead of print]

PMID:
32248689
2.

Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis.

Lozano-Gerona J, Oliván-Viguera A, Delgado-Wicke P, Singh V, Brown BM, Tapia-Casellas E, Pueyo E, Valero MS, Garcia-Otín ÁL, Giraldo P, Abarca-Lachen E, Surra JC, Osada J, Hamilton KL, Raychaudhuri SP, Marigil M, Juarranz Á, Wulff H, Miura H, Gilaberte Y, Köhler R.

PLoS One. 2020 Mar 9;15(3):e0222619. doi: 10.1371/journal.pone.0222619. eCollection 2020.

3.

Jasonia glutinosa (L.) DC., a traditional herbal medicine, reduces inflammation, oxidative stress and protects the intestinal barrier in a murine model of colitis.

Valero MS, González M, Ramón-Gimenez M, Andrade PB, Moreo E, Les F, Fernandes F, Gómez-Rincón C, Berzosa C, García de Jalón JA, Arruebo MP, Plaza MÁ, Köhler R, López V, Valentão P, Castro M.

Inflammopharmacology. 2019 Aug 13. doi: 10.1007/s10787-019-00626-0. [Epub ahead of print]

PMID:
31410747
4.

Web-Based Bioinformatics Predictors: Recommendations to Assess Lysosomal Cholesterol Trafficking Diseases-Related Genes.

López de Frutos L, Cebolla JJ, Irún P, Köhler R, Giraldo P.

Methods Inf Med. 2019 Jun;58(1):50-59. doi: 10.1055/s-0039-1692463. Epub 2019 Jul 5.

PMID:
31277084
5.

Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole.

Simonsen U, Winther AK, Oliván-Viguera A, Comerma-Steffensen S, Köhler R, Bek T.

Int J Mol Sci. 2019 Apr 25;20(8). pii: E2032. doi: 10.3390/ijms20082032.

6.

KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility.

Valero MS, Ramón-Gimenez M, Lozano-Gerona J, Delgado-Wicke P, Calmarza P, Oliván-Viguera A, López V, Garcia-Otín ÁL, Valero S, Pueyo E, Hamilton KL, Miura H, Köhler R.

Int J Mol Sci. 2019 Mar 8;20(5). pii: E1193. doi: 10.3390/ijms20051193.

7.

Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps.

Kriegel FL, Köhler R, Bayat-Sarmadi J, Bayerl S, Hauser AE, Niesner R, Luch A, Cseresnyes Z.

J Vis Exp. 2018 Oct 28;(140). doi: 10.3791/58543.

8.

Elastic to Plastic Deformation in Uniaxially Stressed Polylelectrolyte Multilayer Films.

Frueh J, Rühm A, He Q, Möhwald H, Krastev R, Köhler R.

Langmuir. 2018 Oct 9;34(40):11933-11942. doi: 10.1021/acs.langmuir.8b01296. Epub 2018 Sep 26.

PMID:
30125507
9.

Multiplexed fluorescence microscopy reveals heterogeneity among stromal cells in mouse bone marrow sections.

Holzwarth K, Köhler R, Philipsen L, Tokoyoda K, Ladyhina V, Wählby C, Niesner RA, Hauser AE.

Cytometry A. 2018 Jul;93(9):876-888. doi: 10.1002/cyto.a.23526. Epub 2018 Aug 14.

10.

The erythrocyte osmotic resistance test as screening tool for cholesterol-related lysosomal storage diseases.

López de Frutos L, Cebolla JJ, Irún P, Köhler R, Giraldo P.

Clin Chim Acta. 2018 May;480:161-165. doi: 10.1016/j.cca.2018.02.010. Epub 2018 Feb 13.

PMID:
29447902
11.

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes.

Olivan-Viguera A, Garcia-Otin AL, Lozano-Gerona J, Abarca-Lachen E, Garcia-Malinis AJ, Hamilton KL, Gilaberte Y, Pueyo E, Köhler R.

PLoS One. 2018 Jan 2;13(1):e0190307. doi: 10.1371/journal.pone.0190307. eCollection 2018.

12.

Cell shape characterization and classification with discrete Fourier transforms and self-organizing maps.

Kriegel FL, Köhler R, Bayat-Sarmadi J, Bayerl S, Hauser AE, Niesner R, Luch A, Cseresnyes Z.

Cytometry A. 2018 Mar;93(3):323-333. doi: 10.1002/cyto.a.23279. Epub 2017 Oct 27.

13.

Analyzing Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Aging and Vascular Amyloid Pathology.

Radbruch H, Mothes R, Bremer D, Seifert S, Köhler R, Pohlan J, Ostendorf L, Günther R, Leben R, Stenzel W, Niesner RA, Hauser AE.

Front Immunol. 2017 Jul 31;8:844. doi: 10.3389/fimmu.2017.00844. eCollection 2017.

14.

Down-regulation of KCa2.3 channels causes erectile dysfunction in mice.

Comerma-Steffensen S, Kun A, Hedegaard ER, Mogensen S, Aalkjaer C, Köhler R, Mønster Christensen B, Simonsen U.

Sci Rep. 2017 Jun 19;7(1):3839. doi: 10.1038/s41598-017-04188-5.

15.

Inhibition of Intermediate-Conductance Calcium-Activated K Channel (KCa3.1) and Fibroblast Mitogenesis by α-Linolenic Acid and Alterations of Channel Expression in the Lysosomal Storage Disorders, Fabry Disease, and Niemann Pick C.

Oliván-Viguera A, Lozano-Gerona J, López de Frutos L, Cebolla JJ, Irún P, Abarca-Lachen E, García-Malinis AJ, García-Otín ÁL, Gilaberte Y, Giraldo P, Köhler R.

Front Physiol. 2017 Jan 31;8:39. doi: 10.3389/fphys.2017.00039. eCollection 2017.

16.

Nuclear localization of the CK2α-subunit correlates with poor prognosis in clear cell renal cell carcinoma.

Rabjerg M, Guerra B, Oliván-Viguera A, Mikkelsen ML, Köhler R, Issinger OG, Marcussen N.

Oncotarget. 2017 Jan 3;8(1):1613-1627. doi: 10.18632/oncotarget.13693.

17.

The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury.

Sevelsted Møller L, Fialla AD, Schierwagen R, Biagini M, Liedtke C, Laleman W, Klein S, Reul W, Koch Hansen L, Rabjerg M, Singh V, Surra J, Osada J, Reinehr R, de Muckadell OB, Köhler R, Trebicka J.

Sci Rep. 2016 Jun 29;6:28770. doi: 10.1038/srep28770.

18.

The Effect of Temperature Treatment on the Structure of Polyelectrolyte Multilayers.

Zerball M, Laschewsky A, Köhler R, Von Klitzing R.

Polymers (Basel). 2016 Apr 2;8(4). pii: E120. doi: 10.3390/polym8040120.

19.

Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed.

Oliván-Viguera A, Valero MS, Pinilla E, Amor S, García-Villalón ÁL, Coleman N, Laría C, Calvín-Tienza V, García-Otín ÁL, Fernández-Fernández JM, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Badorrey R, Simonsen U, Rivera L, Wulff H, Köhler R.

Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. doi: 10.1111/bcpt.12560. Epub 2016 Feb 29.

20.

The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke.

Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H.

J Cereb Blood Flow Metab. 2016 Dec;36(12):2146-2161. Epub 2015 Nov 2.

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