Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 116


The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease.

Aimé P, Karuppagounder SS, Rao A, Chen Y, Burke RE, Ratan RR, Greene LA.

Neurobiol Dis. 2020 Mar;136:104725. doi: 10.1016/j.nbd.2019.104725. Epub 2020 Jan 3.


Editorial: The voluminous axon as an organizing principle for traumatic brain injury therapeutics: novel molecular, metabolic, and circuit strategies.

Yoshida Y, Ratan RR.

Curr Opin Neurol. 2019 Dec;32(6):783-785. doi: 10.1097/WCO.0000000000000757. No abstract available.


Paired Associative Stimulation as a Tool to Assess Plasticity Enhancers in Chronic Stroke.

Silverstein J, Cortes M, Tsagaris KZ, Climent A, Gerber LM, Oromendia C, Fonzetti P, Ratan RR, Kitago T, Iacoboni M, Wu A, Dobkin B, Edwards DJ.

Front Neurosci. 2019 Aug 2;13:792. doi: 10.3389/fnins.2019.00792. eCollection 2019.


Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.

Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste Marie EJ, Hondal RJ, Mukherjee S, Cave JW, Sagdullaev BT, Karuppagounder SS, Ratan RR.

Cell. 2019 May 16;177(5):1262-1279.e25. doi: 10.1016/j.cell.2019.03.032. Epub 2019 May 2.


Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors.

Zille M, Kumar A, Kundu N, Bourassa MW, Wong VSC, Willis D, Karuppagounder SS, Ratan RR.

eNeuro. 2019 Feb 15;6(1). pii: ENEURO.0263-18.2019. doi: 10.1523/ENEURO.0263-18.2019. eCollection 2019 Jan-Feb.


Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases.

Karnib N, El-Ghandour R, El Hayek L, Nasrallah P, Khalifeh M, Barmo N, Jabre V, Ibrahim P, Bilen M, Stephan JS, Holson EB, Ratan RR, Sleiman SF.

Neuropsychopharmacology. 2019 May;44(6):1152-1162. doi: 10.1038/s41386-019-0313-z. Epub 2019 Jan 8.


Protecting and repairing the brain: central and peripheral strategies define the New Rehabilitation following traumatic brain injury.

Ratan RR, Schiff ND.

Curr Opin Neurol. 2018 Dec;31(6):669-671. doi: 10.1097/WCO.0000000000000623. No abstract available.


N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.

Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29.


Arginase overexpression in neurons and its effect on traumatic brain injury.

Madan S, Kron B, Jin Z, Al Shamy G, Campeau PM, Sun Q, Chen S, Cherian L, Chen Y, Munivez E, Jiang MM, Robertson C, Goodman C, Ratan RR, Lee B.

Mol Genet Metab. 2018 Sep;125(1-2):112-117. doi: 10.1016/j.ymgme.2018.07.007. Epub 2018 Jul 25.


Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.

Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS.

J Huntingtons Dis. 2018;7(2):137-150. doi: 10.3233/JHD-170274.


Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors.

Gaisina IN, Lee SH, Kaidery NA, Ben Aissa M, Ahuja M, Smirnova NN, Wakade S, Gaisin A, Bourassa MW, Ratan RR, Nikulin SV, Poloznikov AA, Thomas B, Thatcher GRJ, Gazaryan IG.

ACS Chem Neurosci. 2018 May 16;9(5):894-900. doi: 10.1021/acschemneuro.7b00435. Epub 2018 Jan 17.


Rehabilitation following hemorrhagic stroke: building the case for stroke-subtype specific recovery therapies.

Kitago T, Ratan RR.

F1000Res. 2017 Nov 23;6:2044. doi: 10.12688/f1000research.11913.1. eCollection 2017. Review.


Building on NeuroNEXT: Next generation clinics to cure chronic neurological disability.

Ratan RR.

Ann Neurol. 2017 Dec;82(6):859-862. doi: 10.1002/ana.25108. Epub 2017 Dec 8. No abstract available.


Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR.

Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1.


Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease.

Smirnova NA, Kaidery NA, Hushpulian DM, Rakhman II, Poloznikov AA, Tishkov VI, Karuppagounder SS, Gaisina IN, Pekcec A, Leyen KV, Kazakov SV, Yang L, Thomas B, Ratan RR, Gazaryan IG.

Aging Dis. 2016 Dec 1;7(6):745-762. doi: 10.14336/AD.2016.0505. eCollection 2016 Dec.


Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.

Kumar A, Ratan RR.

J Huntingtons Dis. 2016 Oct 1;5(3):217-237. Review.


Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration.

Speer R, Ratan RR.

Adv Exp Med Biol. 2016;903:221-43. doi: 10.1007/978-1-4899-7678-9_16. Review.


Nature and nurture meet at the epigenome to modulate disorders of the nervous system.

Cave JW, Langley B, Ratan RR.

Neurosci Lett. 2016 Jun 20;625:1-3. doi: 10.1016/j.neulet.2016.05.052. No abstract available.


Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.

Ahuja M, Ammal Kaidery N, Yang L, Calingasan N, Smirnova N, Gaisin A, Gaisina IN, Gazaryan I, Hushpulian DM, Kaddour-Djebbar I, Bollag WB, Morgan JC, Ratan RR, Starkov AA, Beal MF, Thomas B.

J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.

Supplemental Content

Loading ...
Support Center