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Items: 9

1.

Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex.

Zaro BW, Vinogradova EV, Lazar DC, Blewett MM, Suciu RM, Takaya J, Studer S, de la Torre JC, Casanova JL, Cravatt BF, Teijaro JR.

J Immunol. 2019 May 1;202(9):2737-2746. doi: 10.4049/jimmunol.1801627. Epub 2019 Mar 18.

PMID:
30885957
2.

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, Yoon E, Lombard DB, Bild A, Mehta G, Romero I, Chiang CY, Landen C, Cravatt B, Hurley TD, Larsen SD, Buckanovich RJ.

Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. doi: 10.1016/j.celrep.2019.02.032.

3.

Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.

Suciu RM, Cognetta AB 3rd, Potter ZE, Cravatt BF.

ACS Med Chem Lett. 2018 May 26;9(6):563-568. doi: 10.1021/acsmedchemlett.8b00191. eCollection 2018 Jun 14.

4.

Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes.

Gao DW, Vinogradova EV, Nimmagadda SK, Medina JM, Xiao Y, Suciu RM, Cravatt BF, Engle KM.

J Am Chem Soc. 2018 Jul 5;140(26):8069-8073. doi: 10.1021/jacs.8b03704. Epub 2018 Jun 22.

PMID:
29894184
5.

Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ.

Lee HY, Suciu RM, Horning BD, Vinogradova EV, Ulanovskaya OA, Cravatt BF.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2682-2687. doi: 10.1016/j.bmcl.2018.04.017. Epub 2018 Apr 10.

PMID:
29731364
6.

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.

Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF.

Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28.

7.

Chemical Proteomic Profiling of Human Methyltransferases.

Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF.

J Am Chem Soc. 2016 Oct 12;138(40):13335-13343. Epub 2016 Sep 30.

8.

GeneDig: a web application for accessing genomic and bioinformatics knowledge.

Suciu RM, Aydin E, Chen BE.

BMC Bioinformatics. 2015 Feb 28;16:67. doi: 10.1186/s12859-015-0497-0.

9.

Nuclear markers of Danube Sturgeons hybridization.

Dudu A, Suciu R, Paraschiv M, Georgescu SE, Costache M, Berrebi P.

Int J Mol Sci. 2011;12(10):6796-809. doi: 10.3390/ijms12106796. Epub 2011 Oct 14.

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