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Items: 1 to 20 of 25


Complete Genome Sequences of the Index Isolates of Two Genotypes of Pacific Salmon Paramyxovirus.

Winton JR, Batts WN, Powers RL, Purcell MK.

Microbiol Resour Announc. 2019 Mar 7;8(10). pii: e01521-18. doi: 10.1128/MRA.01521-18. eCollection 2019 Mar.


Broad-spectrum antiviral JL122 blocks infection and inhibits transmission of aquatic rhabdoviruses.

Balmer BF, Getchell RG, Powers RL, Lee J, Zhang T, Jung ME, Purcell MK, Snekvik K, Aguilar HC.

Virology. 2018 Dec;525:143-149. doi: 10.1016/j.virol.2018.09.009. Epub 2018 Oct 1.


Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239.

Harper TM, June CM, Taracila MA, Bonomo RA, Powers RA, Leonard DA.

Biochem J. 2018 Jan 11;475(1):273-288. doi: 10.1042/BCJ20170702.


Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel β-Lactamase Inhibitors.

Caselli E, Romagnoli C, Powers RA, Taracila MA, Bouza AA, Swanson HC, Smolen KA, Fini F, Wallar BJ, Bonomo RA, Prati F.

ACS Infect Dis. 2018 Mar 9;4(3):337-348. doi: 10.1021/acsinfecdis.7b00153. Epub 2017 Dec 8.


Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C β-Lactamase.

Bouza AA, Swanson HC, Smolen KA, VanDine AL, Taracila MA, Romagnoli C, Caselli E, Prati F, Bonomo RA, Powers RA, Wallar BJ.

ACS Infect Dis. 2018 Mar 9;4(3):325-336. doi: 10.1021/acsinfecdis.7b00152. Epub 2017 Dec 8.


Detection of Nanophyetus salmincola in Water, Snails, and Fish Tissues by Quantitative Polymerase Chain Reaction.

Purcell MK, Powers RL, Besijn BL, Hershberger PK.

J Aquat Anim Health. 2017 Dec;29(4):189-198. doi: 10.1080/08997659.2017.1365780.


Optimization of a Plaque Neutralization Test (PNT) to Identify the Exposure History of Pacific Herring to Viral Hemorrhagic Septicemia Virus (VHSV).

Hart LM, MacKenzie A, Purcell MK, Powers RL, Hershberger PK.

J Aquat Anim Health. 2017 Jun;29(2):74-82. doi: 10.1080/08997659.2017.1285369.


Exploring the potential of boronic acids as inhibitors of OXA-24/40 β-lactamase.

Werner JP, Mitchell JM, Taracila MA, Bonomo RA, Powers RA.

Protein Sci. 2017 Mar;26(3):515-526. doi: 10.1002/pro.3100. Epub 2017 Feb 23.


Inhibition of an Aquatic Rhabdovirus Demonstrates Promise of a Broad-Spectrum Antiviral for Use in Aquaculture.

Balmer BF, Powers RL, Zhang TH, Lee J, Vigant F, Lee B, Jung ME, Purcell MK, Snekvik K, Aguilar HC.

J Virol. 2017 Jan 31;91(4). pii: e02181-16. doi: 10.1128/JVI.02181-16. Print 2017 Feb 15.


The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity.

June CM, Muckenthaler TJ, Schroder EC, Klamer ZL, Wawrzak Z, Powers RA, Szarecka A, Leonard DA.

Protein Sci. 2016 Dec;25(12):2152-2163. doi: 10.1002/pro.3040. Epub 2016 Sep 26.


Ichthyophonus parasite phylogeny based on ITS rDNA structure prediction and alignment identifies six clades, with a single dominant marine type.

Gregg JL, Powers RL, Purcell MK, Friedman CS, Hershberger PK.

Dis Aquat Organ. 2016 Jul 7;120(2):125-41. doi: 10.3354/dao03017.


Structural and Functional Aspects of Extended-Spectrum AmpC Cephalosporinases.

Powers RA.

Curr Drug Targets. 2016;17(9):1051-60. Review.


Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.

Mitchell JM, Clasman JR, June CM, Kaitany KC, LaFleur JR, Taracila MA, Klinger NV, Bonomo RA, Wymore T, Szarecka A, Powers RA, Leonard DA.

Biochemistry. 2015 Mar 17;54(10):1976-87. doi: 10.1021/bi501547k. Epub 2015 Mar 2.


Biochemical and structural analysis of inhibitors targeting the ADC-7 cephalosporinase of Acinetobacter baumannii.

Powers RA, Swanson HC, Taracila MA, Florek NW, Romagnoli C, Caselli E, Prati F, Bonomo RA, Wallar BJ.

Biochemistry. 2014 Dec 9;53(48):7670-9. doi: 10.1021/bi500887n. Epub 2014 Nov 25.


Structure-based efforts to optimize a non-β-lactam inhibitor of AmpC β-lactamase.

Hendershot JM, Mishra UJ, Smart RP, Schroeder W, Powers RA.

Bioorg Med Chem. 2014 Jul 1;22(13):3351-9. doi: 10.1016/j.bmc.2014.04.051. Epub 2014 May 5.


Structural origins of oxacillinase specificity in class D β-lactamases.

June CM, Vallier BC, Bonomo RA, Leonard DA, Powers RA.

Antimicrob Agents Chemother. 2014;58(1):333-41. doi: 10.1128/AAC.01483-13. Epub 2013 Oct 28.


Class D β-lactamases: a reappraisal after five decades.

Leonard DA, Bonomo RA, Powers RA.

Acc Chem Res. 2013 Nov 19;46(11):2407-15. doi: 10.1021/ar300327a. Epub 2013 Jul 31. Review.


Structures of the class D Carbapenemases OXA-23 and OXA-146: mechanistic basis of activity against carbapenems, extended-spectrum cephalosporins, and aztreonam.

Kaitany KC, Klinger NV, June CM, Ramey ME, Bonomo RA, Powers RA, Leonard DA.

Antimicrob Agents Chemother. 2013 Oct;57(10):4848-55. doi: 10.1128/AAC.00762-13. Epub 2013 Jul 22.


Structural analysis of the Asn152Gly mutant of P99 cephalosporinase.

Ruble JF, Lefurgy ST, Cornish VW, Powers RA.

Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1189-93. doi: 10.1107/S0907444912024080. Epub 2012 Aug 18.


Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem.

Schneider KD, Ortega CJ, Renck NA, Bonomo RA, Powers RA, Leonard DA.

J Mol Biol. 2011 Mar 4;406(4):583-94. doi: 10.1016/j.jmb.2010.12.042. Epub 2011 Jan 6.

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