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Items: 1 to 20 of 49


Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target.

Lacey KA, Mulcahy ME, Towell AM, Geoghegan JA, McLoughlin RM.

PLoS Pathog. 2019 Apr 22;15(4):e1007713. doi: 10.1371/journal.ppat.1007713. eCollection 2019 Apr.


Considering the 'Alternatives' for Next-Generation Anti-Staphylococcus aureus Vaccine Development.

O'Brien EC, McLoughlin RM.

Trends Mol Med. 2019 Mar;25(3):171-184. doi: 10.1016/j.molmed.2018.12.010. Epub 2019 Jan 31. Review.


Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?

Connolly R, Denton MD, Humphreys H, McLoughlin RM.

Kidney Int. 2019 Mar;95(3):518-525. doi: 10.1016/j.kint.2018.10.023. Epub 2019 Jan 26. Review.


Next-generation anti-Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?

Clowry J, Irvine AD, McLoughlin RM.

J Allergy Clin Immunol. 2019 Jan;143(1):78-81. doi: 10.1016/j.jaci.2018.08.038. Epub 2018 Sep 12. No abstract available.


The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen.

Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM.

Infect Immun. 2017 Nov 17;85(12). pii: e00549-17. doi: 10.1128/IAI.00549-17. Print 2017 Dec.


Bacterial toxins: Offensive, defensive, or something else altogether?

Rudkin JK, McLoughlin RM, Preston A, Massey RC.

PLoS Pathog. 2017 Sep 21;13(9):e1006452. doi: 10.1371/journal.ppat.1006452. eCollection 2017 Sep. Review.


The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma.

Zasłona Z, Case S, Early JO, Lalor SJ, McLoughlin RM, Curtis AM, O'Neill LAJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L855-L860. doi: 10.1152/ajplung.00072.2017. Epub 2017 Mar 23.


IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.

Leech JM, Lacey KA, Mulcahy ME, Medina E, McLoughlin RM.

J Immunol. 2017 Mar 15;198(6):2352-2365. doi: 10.4049/jimmunol.1601018. Epub 2017 Feb 6.


Interleukin 8 haplotypes drive divergent responses in uterine endometrial cells and are associated with somatic cell score in Holstein-Friesian cattle.

Stojkovic B, Mullen MP, Donofrio G, McLoughlin RM, Meade KG.

Vet Immunol Immunopathol. 2017 Feb;184:18-28. doi: 10.1016/j.vetimm.2016.12.006. Epub 2016 Dec 16.


Staphylococcus aureus and Influenza A Virus: Partners in Coinfection.

Mulcahy ME, McLoughlin RM.

MBio. 2016 Dec 13;7(6). pii: e02068-16. doi: 10.1128/mBio.02068-16.


In vivo relevance of polymorphic Interleukin 8 promoter haplotype for the systemic immune response to LPS in Holstein-Friesian calves.

Stojkovic B, McLoughlin RM, Meade KG.

Vet Immunol Immunopathol. 2016 Dec;182:1-10. doi: 10.1016/j.vetimm.2016.09.006. Epub 2016 Sep 18.


Host-Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization.

Mulcahy ME, McLoughlin RM.

Trends Microbiol. 2016 Nov;24(11):872-886. doi: 10.1016/j.tim.2016.06.012. Epub 2016 Jul 26. Review.


Memory γδ T Cells-Newly Appreciated Protagonists in Infection and Immunity.

Lalor SJ, McLoughlin RM.

Trends Immunol. 2016 Oct;37(10):690-702. doi: 10.1016/ Epub 2016 Aug 23. Review.


The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens.

Lacey KA, Geoghegan JA, McLoughlin RM.

Pathogens. 2016 Feb 17;5(1). pii: E22. doi: 10.3390/pathogens5010022. Review.


Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.

Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM.

PLoS Pathog. 2015 Nov 5;11(11):e1005226. doi: 10.1371/journal.ppat.1005226. eCollection 2015.


Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection.

O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM.

Infect Immun. 2015 Sep;83(9):3445-57. doi: 10.1128/IAI.00358-15. Epub 2015 Jun 22.


Correction: Staphylococcus aureus Infection of mice expands a population of memory γδ T cells that are protective against subsequent infection.

Murphy AG, O'Keeffe KM, Lalor SJ, Maher BM, Mills KH, McLoughlin RM.

J Immunol. 2015 May 1;194(9):4588. doi: 10.4049/jimmunol.1500594. No abstract available.


TRAM is required for TLR2 endosomal signaling to type I IFN induction.

Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG.

J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10.


Staphylococcus aureus infection of mice expands a population of memory γδ T cells that are protective against subsequent infection.

Murphy AG, O'Keeffe KM, Lalor SJ, Maher BM, Mills KH, McLoughlin RM.

J Immunol. 2014 Apr 15;192(8):3697-708. doi: 10.4049/jimmunol.1303420. Epub 2014 Mar 12. Erratum in: J Immunol. 2015 May 1;194(9):4588.


Interleukin-6 signaling drives fibrosis in unresolved inflammation.

Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA.

Immunity. 2014 Jan 16;40(1):40-50. doi: 10.1016/j.immuni.2013.10.022. Epub 2014 Jan 9.

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