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Items: 1 to 20 of 95

1.

Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis.

Yuan S, Hua P, Zhao C, Zhou H, Xu J, Xu J, Gu Q.

J Nat Prod. 2020 Apr 1. doi: 10.1021/acs.jnatprod.9b00929. [Epub ahead of print]

PMID:
32233482
2.

Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.

Guo J, Chen B, Yu Y, Cheng B, Cheng Y, Ju Y, Gu Q, Xu J, Zhou H.

Eur J Med Chem. 2020 Feb 1;187:111941. doi: 10.1016/j.ejmech.2019.111941. Epub 2019 Dec 4.

PMID:
31821989
3.

Diterpenoids from the aerial parts of Flueggea acicularis and their activity against RANKL-induced osteoclastogenesis.

Huang D, Luo X, Yin Z, Xu J, Gu Q.

Bioorg Chem. 2020 Jan;94:103453. doi: 10.1016/j.bioorg.2019.103453. Epub 2019 Nov 23.

PMID:
31787342
4.

Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang.

Zhou X, Li Y, Zhang M, Hao J, Gu Q, Liu H, Chen W, Shi Y, Dong B, Zhang Y, Li C, Li G.

Evid Based Complement Alternat Med. 2019 Sep 22;2019:7282681. doi: 10.1155/2019/7282681. eCollection 2019.

5.

Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis.

Tang J, Ju Y, Gu Q, Xu J, Zhou H.

J Mol Biol. 2019 Dec 6;431(24):4868-4881. doi: 10.1016/j.jmb.2019.10.009. Epub 2019 Oct 18.

PMID:
31634470
6.

Discovery of diverse diterpenoid scaffolds from Euphorbia antiquorum and their activity against RANKL-induced osteoclastogenesis.

Yin ZY, Dai Y, Hua P, Sun ZJ, Cheng YF, Yuan SH, Chen ZY, Gu Q.

Bioorg Chem. 2019 Nov;92:103292. doi: 10.1016/j.bioorg.2019.103292. Epub 2019 Sep 18.

PMID:
31561105
7.

Discovery of tissue selective liver X receptor agonists for the treatment of atherosclerosis without causing hepatic lipogenesis.

Li C, Chen H, Chen X, Li Y, Hua P, Wei J, Song C, Gu Q, Zhou H, Zhang J, Xu J.

Eur J Med Chem. 2019 Nov 15;182:111647. doi: 10.1016/j.ejmech.2019.111647. Epub 2019 Aug 30.

PMID:
31499362
8.

Two new lignans from the aerial parts of Saururus chinensis with cytotoxicity toward nasopharyngeal carcinoma.

Cheng Y, Yin Z, Jiang F, Xu J, Chen H, Gu Q.

Fitoterapia. 2020 Mar;141:104344. doi: 10.1016/j.fitote.2019.104344. Epub 2019 Aug 26.

PMID:
31465814
9.

Identify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay.

Zhang Z, Chen H, Chen Z, Ding P, Ju Y, Gu Q, Xu J, Zhou H.

Eur J Med Chem. 2019 Sep 15;178:458-467. doi: 10.1016/j.ejmech.2019.06.011. Epub 2019 Jun 10.

PMID:
31202993
10.

Structurally Selective Mechanism of Liver X Receptor Ligand: In Silico and In Vitro Studies.

Ding P, Chen Z, Chen H, Zhang Z, Liu Z, Yan X, Zhou H, Gu Q, Li C, Xu J.

J Chem Inf Model. 2019 Jul 22;59(7):3277-3290. doi: 10.1021/acs.jcim.9b00292. Epub 2019 Jun 26.

PMID:
31192592
11.

Systematic Studies on the Protocol and Criteria for Selecting a Covalent Docking Tool.

Wen C, Yan X, Gu Q, Du J, Wu D, Lu Y, Zhou H, Xu J.

Molecules. 2019 Jun 10;24(11). pii: E2183. doi: 10.3390/molecules24112183.

12.

Crystal structure of CntK, the cofactor-independent histidine racemase in staphylopine-mediated metal acquisition of Staphylococcus aureus.

Luo S, Ju Y, Zhou J, Gu Q, Xu J, Zhou H.

Int J Biol Macromol. 2019 Aug 15;135:725-733. doi: 10.1016/j.ijbiomac.2019.05.169. Epub 2019 May 23.

PMID:
31129210
13.

Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach.

Zhao C, Huang D, Li R, Xu Y, Su S, Gu Q, Xu J.

J Med Chem. 2019 Jun 27;62(12):5885-5900. doi: 10.1021/acs.jmedchem.9b00517. Epub 2019 Jun 7.

PMID:
31125222
14.

Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment.

Zhao C, Huang D, Li R, Xu J, Gu Q, Xu J.

Bioorg Chem. 2019 Jun;87:638-646. doi: 10.1016/j.bioorg.2019.03.066. Epub 2019 Mar 28.

PMID:
30947099
15.

Triterpenoids from Euphorbia pulcherrima with inhibitory effects on osteoclastogenesis.

Dai Y, Liu S, Xu J, Zhao C, Gu Q.

Fitoterapia. 2019 Apr;134:355-361. doi: 10.1016/j.fitote.2019.02.028. Epub 2019 Mar 8.

PMID:
30858048
16.

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways.

Zhou L, Liu Q, Hong G, Song F, Zhao J, Yuan J, Xu J, Tan RX, Tickner J, Gu Q, Xu J.

FASEB J. 2019 Jun;33(6):6726-6735. doi: 10.1096/fj.201800883RRR. Epub 2019 Feb 26.

PMID:
30807230
17.

Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease.

Fang Y, Zhou H, Gu Q, Xu J.

Eur J Med Chem. 2019 Apr 1;167:133-145. doi: 10.1016/j.ejmech.2019.02.008. Epub 2019 Feb 4.

PMID:
30771601
18.

DeepChemStable: Chemical Stability Prediction with an Attention-Based Graph Convolution Network.

Li X, Yan X, Gu Q, Zhou H, Wu D, Xu J.

J Chem Inf Model. 2019 Mar 25;59(3):1044-1049. doi: 10.1021/acs.jcim.8b00672. Epub 2019 Feb 21.

PMID:
30764613
19.

Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum.

Luo P, Cheng Y, Yin Z, Li C, Xu J, Gu Q.

J Nat Prod. 2019 Feb 22;82(2):349-357. doi: 10.1021/acs.jnatprod.8b00863. Epub 2019 Feb 6.

PMID:
30726671
20.

QBMG: quasi-biogenic molecule generator with deep recurrent neural network.

Zheng S, Yan X, Gu Q, Yang Y, Du Y, Lu Y, Xu J.

J Cheminform. 2019 Jan 17;11(1):5. doi: 10.1186/s13321-019-0328-9.

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