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Items: 1 to 20 of 93

1.

Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma.

Liu YJ, Chang YJ, Kuo YT, Liang PH.

Carcinogenesis. 2019 Aug 11. pii: bgz137. doi: 10.1093/carcin/bgz137. [Epub ahead of print]

PMID:
31400757
2.

Characterization of a Cis-Prenyltransferase from Lilium longiflorum Anther.

Yao JY, Teng KH, Liu MC, Wang CS, Liang PH.

Molecules. 2019 Jul 26;24(15). pii: E2728. doi: 10.3390/molecules24152728.

3.

The Penetration Depth for Hanatoxin Partitioning into the Membrane Hydrocarbon Core Measured with Neutron Reflectivity.

Hsieh MH, Huang PT, Liou HH, Liang PH, Chen PM, Holt SA, Yu IF, James M, Shiau YS, Lee MT, Lin TL, Lou KL.

Langmuir. 2018 Jul 31;34(30):9036-9046. doi: 10.1021/acs.langmuir.8b01076. Epub 2018 Jul 20.

PMID:
29986585
4.

Caspase-3, a key apoptotic protein, as a prognostic marker in gastric cancer after curative surgery.

Huang KH, Fang WL, Li AF, Liang PH, Wu CW, Shyr YM, Yang MH.

Int J Surg. 2018 Apr;52:258-263. doi: 10.1016/j.ijsu.2018.02.055. Epub 2018 Mar 1.

PMID:
29501797
5.

A flexible loop for mannan recognition and activity enhancement in a bifunctional glycoside hydrolase family 5.

Liang PH, Lin WL, Hsieh HY, Lin TY, Chen CH, Tewary SK, Lee HL, Yuan SF, Yang B, Yao JY, Ho MC.

Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):513-521. doi: 10.1016/j.bbagen.2017.11.004. Epub 2017 Nov 3.

PMID:
29108954
6.

Disrupting CCT-β : β-tubulin selectively kills CCT-β overexpressed cancer cells through MAPKs activation.

Liu YJ, Kumar V, Lin YF, Liang PH.

Cell Death Dis. 2017 Sep 14;8(9):e3052. doi: 10.1038/cddis.2017.425.

7.

Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors.

Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH.

Antiviral Res. 2017 May;141:101-106. doi: 10.1016/j.antiviral.2017.02.007. Epub 2017 Feb 17.

PMID:
28216367
8.

Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors.

Teng KH, Hsu ET, Chang YH, Lin SW, Liang PH.

Biochemistry. 2016 Aug 9;55(31):4366-74. doi: 10.1021/acs.biochem.6b00486. Epub 2016 Jul 28.

PMID:
27428767
9.

Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.

Kumar V, Tan KP, Wang YM, Lin SW, Liang PH.

Bioorg Med Chem. 2016 Jul 1;24(13):3035-3042. doi: 10.1016/j.bmc.2016.05.013. Epub 2016 May 12.

10.

Structures of exoglucanase from Clostridium cellulovorans: cellotetraose binding and cleavage.

Tsai LC, Amiraslanov I, Chen HR, Chen YW, Lee HL, Liang PH, Liaw YC.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1264-72. doi: 10.1107/S2053230X15015915. Epub 2015 Sep 23.

11.

Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum.

Yuan SF, Wu TH, Lee HL, Hsieh HY, Lin WL, Yang B, Chang CK, Li Q, Gao J, Huang CH, Ho MC, Guo RT, Liang PH.

J Biol Chem. 2015 Feb 27;290(9):5739-48. doi: 10.1074/jbc.M114.604454. Epub 2015 Jan 9.

12.

Identification, synthesis, and evaluation of new neuraminidase inhibitors.

Kumar V, Chang CK, Tan KP, Jung YS, Chen SH, Cheng YS, Liang PH.

Org Lett. 2014 Oct 3;16(19):5060-3. doi: 10.1021/ol502410x. Epub 2014 Sep 17.

PMID:
25229881
13.

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms.

Han X, Chen CC, Kuo CJ, Huang CH, Zheng Y, Ko TP, Zhu Z, Feng X, Wang K, Oldfield E, Wang AH, Liang PH, Guo RT, Ma Y.

Proteins. 2015 Jan;83(1):37-45. doi: 10.1002/prot.24618. Epub 2014 Nov 18.

14.

Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis.

Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, Oldfield E, Guo RT.

J Am Chem Soc. 2014 Feb 19;136(7):2892-6. doi: 10.1021/ja413127v. Epub 2014 Feb 5.

15.

Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.

Al-Mudaris ZA, Majid AS, Ji D, Al-Mudarris BA, Chen SH, Liang PH, Osman H, Jamal Din SK, Abdul Majid AM.

PLoS One. 2013 Nov 15;8(11):e80983. doi: 10.1371/journal.pone.0080983. eCollection 2013.

16.

Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.

Lin YF, Lai TC, Chang CK, Chen CL, Huang MS, Yang CJ, Liu HG, Dong JJ, Chou YA, Teng KH, Chen SH, Tian WT, Jan YH, Hsiao M, Liang PH.

J Clin Invest. 2013 Sep;123(9):3861-75. doi: 10.1172/JCI67951. Epub 2013 Aug 27.

17.

Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase.

Chen SH, Lin SW, Lin SR, Liang PH, Yang JM.

J Chem Inf Model. 2013 Sep 23;53(9):2299-311. doi: 10.1021/ci400227r. Epub 2013 Aug 26.

PMID:
23919676
18.

Anti-SARS coronavirus agents: a patent review (2008 - present).

Kumar V, Jung YS, Liang PH.

Expert Opin Ther Pat. 2013 Oct;23(10):1337-48. doi: 10.1517/13543776.2013.823159. Epub 2013 Aug 2. Review.

PMID:
23905913
19.

The catalytic roles of P185 and T188 and substrate-binding loop flexibility in 3α-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni.

Hwang CC, Chang YH, Lee HJ, Wang TP, Su YM, Chen HW, Liang PH.

PLoS One. 2013 May 23;8(5):e63594. doi: 10.1371/journal.pone.0063594. Print 2013.

20.

Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction.

Chang CK, Teng KH, Lin SW, Chang TH, Liang PH.

Biochemistry. 2013 Apr 23;52(16):2783-92. doi: 10.1021/bi4001276. Epub 2013 Apr 11.

PMID:
23534508

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