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Items: 14

1.

SIRT1 modulates cell cycle progression by regulating CHK2 acetylation-phosphorylation.

Zhang W, Feng Y, Guo Q, Guo W, Xu H, Li X, Yi F, Guan Y, Geng N, Wang P, Cao L, O'Rourke BP, Jo J, Kwon J, Wang R, Song X, Lee IH, Cao L.

Cell Death Differ. 2019 Jun 17. doi: 10.1038/s41418-019-0369-7. [Epub ahead of print]

PMID:
31209362
2.

Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists.

Wang P, Felsing DE, Chen H, Raval SR, Allen JA, Zhou J.

ACS Med Chem Lett. 2019 Apr 5;10(5):792-799. doi: 10.1021/acsmedchemlett.9b00050. eCollection 2019 May 9.

PMID:
31098001
3.

Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.

Griggs RB, Santos DF, Laird DE, Doolen S, Donahue RR, Wessel CR, Fu W, Sinha GP, Wang P, Zhou J, Brings S, Fleming T, Nawroth PP, Susuki K, Taylor BK.

Neurobiol Dis. 2019 Jul;127:76-86. doi: 10.1016/j.nbd.2019.02.019. Epub 2019 Feb 23.

PMID:
30807826
4.

Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions.

Liu Z, Wadsworth P, Singh AK, Chen H, Wang P, Folorunso O, Scaduto P, Ali SR, Laezza F, Zhou J.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):413-419. doi: 10.1016/j.bmcl.2018.12.031. Epub 2018 Dec 15.

PMID:
30587448
5.

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery.

Wang P, Zhou J.

Curr Top Med Chem. 2018;18(16):1354-1356. doi: 10.2174/1568026618666181010101922. Review.

PMID:
30306871
6.

Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection.

Choi EJ, Ren Y, Chen Y, Liu S, Wu W, Ren J, Wang P, Garofalo RP, Zhou J, Bao X.

J Virol. 2018 Oct 29;92(22). pii: e01200-18. doi: 10.1128/JVI.01200-18. Print 2018 Nov 15.

7.

Small-Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models.

Sampson CM, Kasper JM, Felsing DE, Raval SR, Ye N, Wang P, Patrikeev I, Rytting E, Zhou J, Allen JA, Hommel JD.

Pharmacol Res Perspect. 2018 Aug 23;6(5):e00425. doi: 10.1002/prp2.425. eCollection 2018 Oct.

8.

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation.

Liu Z, Tian B, Chen H, Wang P, Brasier AR, Zhou J.

Eur J Med Chem. 2018 May 10;151:450-461. doi: 10.1016/j.ejmech.2018.04.006. Epub 2018 Apr 3.

9.

Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads.

Ding Y, Li D, Ding C, Wang P, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J.

J Med Chem. 2018 Apr 12;61(7):2737-2752. doi: 10.1021/acs.jmedchem.7b01514. Epub 2018 Mar 20.

10.

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).

Liu Z, Zhu Y, Chen H, Wang P, Mei FC, Ye N, Cheng X, Zhou J.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5163-5166. doi: 10.1016/j.bmcl.2017.10.056. Epub 2017 Oct 25.

11.

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.

Ye N, Zhu Y, Liu Z, Mei FC, Chen H, Wang P, Cheng X, Zhou J.

Eur J Med Chem. 2017 Jul 7;134:62-71. doi: 10.1016/j.ejmech.2017.04.001. Epub 2017 Apr 4.

12.

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.

Wang P, Liu Z, Chen H, Ye N, Cheng X, Zhou J.

Bioorg Med Chem Lett. 2017 Apr 15;27(8):1633-1639. doi: 10.1016/j.bmcl.2017.02.065. Epub 2017 Feb 27. Review.

13.

Drug Discovery Targeting Bromodomain-Containing Protein 4.

Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J.

J Med Chem. 2017 Jun 8;60(11):4533-4558. doi: 10.1021/acs.jmedchem.6b01761. Epub 2017 Mar 2. Review.

14.

InBr3-mediated one-pot synthesis of 2-(polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-cyclopropa-3-pyranone and amines.

Wang P, Song S, Miao Z, Yang G, Zhang A.

Org Lett. 2013 Aug 2;15(15):3852-5. doi: 10.1021/ol401489x. Epub 2013 Jul 15.

PMID:
23855782

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