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Items: 1 to 20 of 26

1.

Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral Serotonin.

Sibon D, Coman T, Rossignol J, Lamarque M, Kosmider O, Bayard E, Fouquet G, Rignault R, Topçu S, Bonneau P, Bernex F, Dussiot M, Deroy K, Laurent L, Callebert J, Launay JM, Georgin-Lavialle S, Courtois G, Maroteaux L, Vaillancourt C, Fontenay M, Hermine O, Côté F.

Cell Rep. 2019 Mar 19;26(12):3246-3256.e4. doi: 10.1016/j.celrep.2019.02.071.

2.

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.

Fader LD, Bailey M, Beaulieu E, Bilodeau F, Bonneau P, Bousquet Y, Carson RJ, Chabot C, Coulombe R, Duan J, Fenwick C, Garneau M, Halmos T, Jakalian A, James C, Kawai SH, Landry S, LaPlante SR, Mason SW, Morin S, Rioux N, Simoneau B, Surprenant S, Thavonekham B, Thibeault C, Trinh T, Tsantrizos Y, Tsoung J, Yoakim C, Wernic D.

ACS Med Chem Lett. 2016 Jun 9;7(8):797-801. doi: 10.1021/acsmedchemlett.6b00194. eCollection 2016 Aug 11.

3.

Implementation of ultrasonic sensing for high resolution measurement of binary gas mixture fractions.

Bates R, Battistin M, Berry S, Bitadze A, Bonneau P, Bousson N, Boyd G, Bozza G, Crespo-Lopez O, Da Riva E, Degeorge C, Deterre C, DiGirolamo B, Doubek M, Favre G, Godlewski J, Hallewell G, Hasib A, Katunin S, Langevin N, Lombard D, Mathieu M, McMahon S, Nagai K, Pearson B, Robinson D, Rossi C, Rozanov A, Strauss M, Vitek M, Vacek V, Zwalinski L.

Sensors (Basel). 2014 Jun 24;14(6):11260-76. doi: 10.3390/s140611260.

4.

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.

Fader LD, Malenfant E, Parisien M, Carson R, Bilodeau F, Landry S, Pesant M, Brochu C, Morin S, Chabot C, Halmos T, Bousquet Y, Bailey MD, Kawai SH, Coulombe R, LaPlante S, Jakalian A, Bhardwaj PK, Wernic D, Schroeder P, Amad M, Edwards P, Garneau M, Duan J, Cordingley M, Bethell R, Mason SW, Bös M, Bonneau P, Poupart MA, Faucher AM, Simoneau B, Fenwick C, Yoakim C, Tsantrizos Y.

ACS Med Chem Lett. 2014 Jan 22;5(4):422-7. doi: 10.1021/ml500002n. eCollection 2014 Apr 10.

5.

Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor.

Fenwick C, Amad M, Bailey MD, Bethell R, Bös M, Bonneau P, Cordingley M, Coulombe R, Duan J, Edwards P, Fader LD, Faucher AM, Garneau M, Jakalian A, Kawai S, Lamorte L, LaPlante S, Luo L, Mason S, Poupart MA, Rioux N, Schroeder P, Simoneau B, Tremblay S, Tsantrizos Y, Witvrouw M, Yoakim C.

Antimicrob Agents Chemother. 2014 Jun;58(6):3233-44. doi: 10.1128/AAC.02719-13. Epub 2014 Mar 24.

6.

Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.

LaPlante SR, Padyana AK, Abeywardane A, Bonneau P, Cartier M, Coulombe R, Jakalian A, Wildeson-Jones J, Li X, Liang S, McKercher G, White P, Zhang Q, Taylor SJ.

J Med Chem. 2014 Mar 13;57(5):2074-90. doi: 10.1021/jm401432c. Epub 2014 Jan 27.

PMID:
24467709
7.

Monitoring drug self-aggregation and potential for promiscuity in off-target in vitro pharmacology screens by a practical NMR strategy.

LaPlante SR, Aubry N, Bolger G, Bonneau P, Carson R, Coulombe R, Sturino C, Beaulieu PL.

J Med Chem. 2013 Sep 12;56(17):7073-83. doi: 10.1021/jm4008714. Epub 2013 Aug 22.

PMID:
23919803
8.

Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.

Hucke O, Coulombe R, Bonneau P, Bertrand-Laperle M, Brochu C, Gillard J, Joly MA, Landry S, Lepage O, Llinàs-Brunet M, Pesant M, Poirier M, Poirier M, McKercher G, Marquis M, Kukolj G, Beaulieu PL, Stammers TA.

J Med Chem. 2014 Mar 13;57(5):1932-43. doi: 10.1021/jm4004522. Epub 2013 Jul 12.

PMID:
23773186
9.

Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.

LaPlante SR, Carson R, Gillard J, Aubry N, Coulombe R, Bordeleau S, Bonneau P, Little M, O'Meara J, Beaulieu PL.

J Med Chem. 2013 Jun 27;56(12):5142-50. doi: 10.1021/jm400535b. Epub 2013 Jun 13.

PMID:
23730910
10.

A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization.

Lemke CT, Titolo S, Goudreau N, Faucher AM, Mason SW, Bonneau P.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1115-23. doi: 10.1107/S0907444913006409. Epub 2013 May 15.

PMID:
23695256
11.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

Fader LD, Landry S, Goulet S, Morin S, Kawai SH, Bousquet Y, Dion I, Hucke O, Goudreau N, Lemke CT, Rancourt J, Bonneau P, Titolo S, Amad M, Garneau M, Duan J, Mason S, Simoneau B.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3401-5. doi: 10.1016/j.bmcl.2013.03.074. Epub 2013 Apr 3.

PMID:
23601710
12.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

Fader LD, Landry S, Morin S, Kawai SH, Bousquet Y, Hucke O, Goudreau N, Lemke CT, Bonneau P, Titolo S, Mason S, Simoneau B.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3396-400. doi: 10.1016/j.bmcl.2013.03.073. Epub 2013 Mar 28.

PMID:
23583513
13.

Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry.

Goudreau N, Hucke O, Faucher AM, Grand-Maître C, Lepage O, Bonneau PR, Mason SW, Titolo S.

J Mol Biol. 2013 Jun 12;425(11):1982-1998. doi: 10.1016/j.jmb.2013.02.022. Epub 2013 Feb 26.

PMID:
23485336
14.

Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions.

Sedykh A, Fourches D, Duan J, Hucke O, Garneau M, Zhu H, Bonneau P, Tropsha A.

Pharm Res. 2013 Apr;30(4):996-1007. doi: 10.1007/s11095-012-0935-x. Epub 2012 Dec 27.

15.

Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.

Tremblay M, Bonneau P, Bousquet Y, DeRoy P, Duan J, Duplessis M, Gagnon A, Garneau M, Goudreau N, Guse I, Hucke O, Kawai SH, Lemke CT, Mason SW, Simoneau B, Surprenant S, Titolo S, Yoakim C.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7512-7. doi: 10.1016/j.bmcl.2012.10.034. Epub 2012 Oct 16.

PMID:
23122820
16.

HTS promiscuity analyses for accelerating decision making.

Böcker A, Bonneau PR, Edwards PJ.

J Biomol Screen. 2011 Aug;16(7):765-74. doi: 10.1177/1087057111407763. Epub 2011 Jun 16.

PMID:
21680863
17.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

Fader LD, Bethell R, Bonneau P, Bös M, Bousquet Y, Cordingley MG, Coulombe R, Deroy P, Faucher AM, Gagnon A, Goudreau N, Grand-Maître C, Guse I, Hucke O, Kawai SH, Lacoste JE, Landry S, Lemke CT, Malenfant E, Mason S, Morin S, O'Meara J, Simoneau B, Titolo S, Yoakim C.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):398-404. doi: 10.1016/j.bmcl.2010.10.131. Epub 2010 Oct 31.

PMID:
21087861
18.

Development of specific "drug-like property" rules for carboxylate-containing oral drug candidates.

Böcker A, Bonneau PR, Hucke O, Jakalian A, Edwards PJ.

ChemMedChem. 2010 Dec 3;5(12):2102-13. doi: 10.1002/cmdc.201000355.

PMID:
20979082
19.

Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.

Gagnon A, Landry S, Coulombe R, Jakalian A, Guse I, Thavonekham B, Bonneau PR, Yoakim C, Simoneau B.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1199-205. doi: 10.1016/j.bmcl.2008.12.074. Epub 2008 Dec 24.

PMID:
19138518
20.

Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.

Gagnon A, Amad MH, Bonneau PR, Coulombe R, DeRoy PL, Doyon L, Duan J, Garneau M, Guse I, Jakalian A, Jolicoeur E, Landry S, Malenfant E, Simoneau B, Yoakim C.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4437-41. Epub 2007 Jun 8.

PMID:
17583503

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