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Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application?

Sasse P, Funken M, Beiert T, Bruegmann T.

Front Physiol. 2019 Jun 6;10:675. doi: 10.3389/fphys.2019.00675. eCollection 2019. Review.


Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia.

Funken M, Malan D, Sasse P, Bruegmann T.

Front Physiol. 2019 Apr 24;10:498. doi: 10.3389/fphys.2019.00498. eCollection 2019.


Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision.

Makowka P, Bruegmann T, Dusend V, Malan D, Beiert T, Hesse M, Fleischmann BK, Sasse P.

Nat Commun. 2019 Mar 20;10(1):1281. doi: 10.1038/s41467-019-09322-7.


Optical control of L-type Ca2+ channels using a diltiazem photoswitch.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D.

Nat Chem Biol. 2018 Aug;14(8):764-767. doi: 10.1038/s41589-018-0090-8. Epub 2018 Jul 16.


Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling.

Roell W, Klein AM, Breitbach M, Becker TS, Parikh A, Lee J, Zimmermann K, Reining S, Gabris B, Ottersbach A, Doran R, Engelbrecht B, Schiffer M, Kimura K, Freitag P, Carls E, Geisen C, Duerr GD, Sasse P, Welz A, Pfeifer A, Salama G, Kotlikoff M, Fleischmann BK.

Sci Rep. 2018 May 8;8(1):7145. doi: 10.1038/s41598-018-25147-8.


Sympathetic control of cardiac output by noradrenaline: quasi-synaptic quantal release or interstitial diffusion and spillover?

Sasse P.

J Physiol. 2018 Jun;596(11):2031-2032. doi: 10.1113/JP276109. Epub 2018 May 10. No abstract available.


Optogenetic termination of atrial fibrillation in mice.

Bruegmann T, Beiert T, Vogt CC, Schrickel JW, Sasse P.

Cardiovasc Res. 2018 Apr 1;114(5):713-723. doi: 10.1093/cvr/cvx250.


Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation.

Rehnelt S, Malan D, Juhasz K, Wolters B, Doerr L, Beckler M, Kettenhofen R, Bohlen H, Bruegmann T, Sasse P.

Int J Mol Sci. 2017 Dec 6;18(12). pii: E2634. doi: 10.3390/ijms18122634.


Improved heart repair upon myocardial infarction: Combination of magnetic nanoparticles and tailored magnets strongly increases engraftment of myocytes.

Ottersbach A, Mykhaylyk O, Heidsieck A, Eberbeck D, Rieck S, Zimmermann K, Breitbach M, Engelbrecht B, Brügmann T, Hesse M, Welz A, Sasse P, Wenzel D, Plank C, Gleich B, Hölzel M, Bloch W, Pfeifer A, Fleischmann BK, Roell W.

Biomaterials. 2018 Feb;155:176-190. doi: 10.1016/j.biomaterials.2017.11.012. Epub 2017 Nov 15.


Spot light on skeletal muscles: optogenetic stimulation to understand and restore skeletal muscle function.

van Bremen T, Send T, Sasse P, Bruegmann T.

J Muscle Res Cell Motil. 2017 Aug;38(3-4):331-337. doi: 10.1007/s10974-017-9481-9. Epub 2017 Sep 16.


Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes.

Lapp H, Bruegmann T, Malan D, Friedrichs S, Kilgus C, Heidsieck A, Sasse P.

Sci Rep. 2017 Aug 29;7(1):9629. doi: 10.1038/s41598-017-09760-7.


EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival.

Jara-Avaca M, Kempf H, Rückert M, Robles-Diaz D, Franke A, de la Roche J, Fischer M, Malan D, Sasse P, Solodenko W, Dräger G, Kirschning A, Martin U, Zweigerdt R.

Stem Cell Reports. 2017 Feb 14;8(2):305-317. doi: 10.1016/j.stemcr.2016.12.012. Epub 2017 Jan 12.


Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor.

Seemann WK, Wenzel D, Schrage R, Etscheid J, Bödefeld T, Bartol A, Warnken M, Sasse P, Klöckner J, Holzgrabe U, DeAmici M, Schlicker E, Racké K, Kostenis E, Meyer R, Fleischmann BK, Mohr K.

J Pharmacol Exp Ther. 2017 Feb;360(2):289-299. doi: 10.1124/jpet.116.237149. Epub 2016 Nov 15.


Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.

Bruegmann T, Boyle PM, Vogt CC, Karathanos TV, Arevalo HJ, Fleischmann BK, Trayanova NA, Sasse P.

J Clin Invest. 2016 Oct 3;126(10):3894-3904. doi: 10.1172/JCI88950. Epub 2016 Sep 12.


Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction.

Malan D, Zhang M, Stallmeyer B, Müller J, Fleischmann BK, Schulze-Bahr E, Sasse P, Greber B.

Basic Res Cardiol. 2016 Mar;111(2):14. doi: 10.1007/s00395-016-0530-0. Epub 2016 Jan 23.


Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy.

Friedrichs S, Malan D, Voss Y, Sasse P.

J Clin Med. 2015 Jan 8;4(1):102-23. doi: 10.3390/jcm4010102.


Optogenetic control of contractile function in skeletal muscle.

Bruegmann T, van Bremen T, Vogt CC, Send T, Fleischmann BK, Sasse P.

Nat Commun. 2015 Jun 2;6:7153. doi: 10.1038/ncomms8153.


Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.

Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B.

Stem Cells. 2015 May;33(5):1456-69. doi: 10.1002/stem.1964.


Systemic gene transfer enables optogenetic pacing of mouse hearts.

Vogt CC, Bruegmann T, Malan D, Ottersbach A, Roell W, Fleischmann BK, Sasse P.

Cardiovasc Res. 2015 May 1;106(2):338-43. doi: 10.1093/cvr/cvv004. Epub 2015 Jan 12.


Human Connexin43E42K mutation from a sudden infant death victim leads to impaired ventricular activation and neonatal death in mice.

Lübkemeier I, Bosen F, Kim JS, Sasse P, Malan D, Fleischmann BK, Willecke K.

Circ Cardiovasc Genet. 2015 Feb;8(1):21-9. doi: 10.1161/CIRCGENETICS.114.000793. Epub 2014 Dec 10.


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