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Pathogens. 2019 Sep 21;8(4). pii: E158. doi: 10.3390/pathogens8040158.

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice.

Author information

1
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA. jonna.westover@usu.edu.
2
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA. brady.hickerson@aggiemail.usu.edu.
3
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA. arnaud.vanwettere@usu.edu.
4
Utah Veterinary Diagnostic Laboratory, Utah State University, Logan, UT 84341, USA. arnaud.vanwettere@usu.edu.
5
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA. brett.hurst@usu.edu.
6
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA. jacqueline.larose@usu.edu.
7
Utah Veterinary Diagnostic Laboratory, Utah State University, Logan, UT 84341, USA. jacqueline.larose@usu.edu.
8
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA. ashley.dagley@usu.edu.
9
MChE-Trading Handels-GmbH, Vienna 1060, Austria. petra.wuelfroth@accella-advisors.com.
10
FUJIFILM Toyama Chemical Co., Ltd., Toyama 930-8508, Japan. TAKASHI_KOMENO@toyama-chemical.co.jp.
11
FUJIFILM Toyama Chemical Co., Ltd., Toyama 930-8508, Japan. Yousuke_Furuta@toyama-chemical.co.jp.
12
MChE-Trading Handels-GmbH, Vienna 1060, Austria. thomas.steiner@mche.at.
13
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA. brian.gowen@usu.edu.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR-/- mice challenged with the HB29 strain of SFTS virus (SFTSV) and demonstrate hallmark features of VHF such as vascular leak and high concentrations of proinflammatory cytokines in blood and tissues. Treatment with FX06, a natural plasmin digest product of fibrin in clinical development as a treatment for vascular leak, reduced vascular permeability associated with SFTSV infection but did not significantly improve survival outcome. Further studies are needed to assess the role of vascular compromise in the SFTS disease process modeled in IFNAR-/- mice.

KEYWORDS:

Huaiyangshan banyangvirus; cytokine storm; severe fever with thrombocytopenia syndrome; vascular leak; viral hemorrhagic fever

PMID:
31546590
DOI:
10.3390/pathogens8040158
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