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Items: 1 to 20 of 34


Overexpression of IGF-IIRα regulates cardiac remodeling and aggravates high salt induced apoptosis and fibrosis in transgenic rats.

Chang RL, Nithiyanantham S, Kuo WW, Pai PY, Chang TT, Lai CH, Chen RJ, Vijaya Padma V, Huang CY, Huang CY.

Environ Toxicol. 2019 Feb;34(2):210-218. doi: 10.1002/tox.22676. Epub 2018 Nov 18.


Inhibition of ERK-Drp1 signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure.

Huang CY, Lai CH, Kuo CH, Chiang SF, Pai PY, Lin JY, Chang CF, Viswanadha VP, Kuo WW, Huang CY.

J Mol Cell Cardiol. 2018 Sep;122:58-68. doi: 10.1016/j.yjmcc.2018.08.006. Epub 2018 Aug 9.


Rab9-dependent autophagy is required for the IGF-IIR triggering mitophagy to eliminate damaged mitochondria.

Huang CY, Kuo WW, Ho TJ, Chiang SF, Pai PY, Lin JY, Lin DY, Kuo CH, Huang CY.

J Cell Physiol. 2018 Sep;233(9):7080-7091. doi: 10.1002/jcp.26346. Epub 2018 Mar 25.


Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure.

Huang CY, Kuo CH, Pai PY, Ho TJ, Lin YM, Chen RJ, Tsai FJ, Vijaya Padma V, Kuo WW, Huang CY.

Data Brief. 2017 Nov 20;16:521-526. doi: 10.1016/j.dib.2017.11.040. eCollection 2018 Feb.


Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy.

Huang CY, Kuo CH, Pai PY, Ho TJ, Lin YM, Chen RJ, Tsai FJ, Vijaya Padma V, Kuo WW, Huang CY.

Int J Cardiol. 2018 Apr 15;257:283-290. doi: 10.1016/j.ijcard.2017.10.102. Epub 2017 Nov 10.


Diallyl trisulfide suppresses doxorubicin-induced cardiomyocyte apoptosis by inhibiting MAPK/NF-κB signaling through attenuation of ROS generation.

Wen SY, Tsai CY, Pai PY, Chen YW, Yang YC, Aneja R, Huang CY, Kuo WW.

Environ Toxicol. 2018 Jan;33(1):93-103. doi: 10.1002/tox.22500. Epub 2017 Oct 31.


Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy.

Chen YF, Lee NH, Pai PY, Chung LC, Shen CY, Rajendran P, Chen YF, Chen RJ, Padma Viswanadha V, Kuo WW, Huang CY.

J Recept Signal Transduct Res. 2017 Oct;37(5):493-499. doi: 10.1080/10799893.2017.1360349.


Increased β-catenin accumulation and nuclear translocation are associated with concentric hypertrophy in cardiomyocytes.

Lee CY, Kuo WW, Baskaran R, Day CH, Pai PY, Lai CH, Chen YF, Chen RJ, Padma VV, Huang CY.

Cardiovasc Pathol. 2017 Nov - Dec;31:9-16. doi: 10.1016/j.carpath.2017.07.003. Epub 2017 Jul 12.


p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure.

Huang CY, Pai PY, Kuo CH, Ho TJ, Lin JY, Lin DY, Tsai FJ, Padma VV, Kuo WW, Huang CY.

Cell Death Dis. 2017 Aug 10;8(8):e2990. doi: 10.1038/cddis.2017.320.


Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism.

Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, Brighton TA, Cohen AT, Davidson BL, Decousus H, Freitas MCS, Holberg G, Kakkar AK, Haskell L, van Bellen B, Pap AF, Berkowitz SD, Verhamme P, Wells PS, Prandoni P; EINSTEIN CHOICE Investigators.

N Engl J Med. 2017 Mar 30;376(13):1211-1222. doi: 10.1056/NEJMoa1700518. Epub 2017 Mar 18.


Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT1 R upregulation are required for doxorubicin-induced cardiotoxicity.

Huang CY, Chen JY, Kuo CH, Pai PY, Ho TJ, Chen TS, Tsai FJ, Padma VV, Kuo WW, Huang CY.

J Cell Physiol. 2018 Jan;233(1):463-475. doi: 10.1002/jcp.25905. Epub 2017 May 3.


Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death.

Huang CY, Kuo WW, Lo JF, Ho TJ, Pai PY, Chiang SF, Chen PY, Tsai FJ, Tsai CH, Huang CY.

Cell Death Dis. 2016 Nov 3;7(11):e2455. doi: 10.1038/cddis.2016.356.


Management of Venous Thromboembolisms: Part I. The Consensus for Deep Vein Thrombosis.

Wang KL, Chu PH, Lee CH, Pai PY, Lin PY, Shyu KG, Chang WT, Chiu KM, Huang CL, Lee CY, Lin YH, Wang CC, Yen HW, Yin WH, Yeh HI, Chiang CE, Lin SJ, Yeh SJ.

Acta Cardiol Sin. 2016 Jan;32(1):1-22. Review.


Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats.

Lai CH, Tsai CC, Kuo WW, Ho TJ, Day CH, Pai PY, Chung LC, Huang CC, Wang HF, Liao PH, Huang CY.

Int J Med Sci. 2016 Mar 30;13(4):277-85. doi: 10.7150/ijms.14769. eCollection 2016.


Tanshinone IIA Prevents Leu27IGF-II-Induced Cardiomyocyte Hypertrophy Mediated by Estrogen Receptor and Subsequent Akt Activation.

Weng YS, Wang HF, Pai PY, Jong GP, Lai CH, Chung LC, Hsieh DJ, HsuanDay C, Kuo WW, Huang CY.

Am J Chin Med. 2015;43(8):1567-91. doi: 10.1142/S0192415X15500895. Epub 2015 Nov 30.


CREB Negatively Regulates IGF2R Gene Expression and Downstream Pathways to Inhibit Hypoxia-Induced H9c2 Cardiomyoblast Cell Death.

Chen WK, Kuo WW, Hsieh DJ, Chang HN, Pai PY, Lin KH, Pan LF, Ho TJ, Viswanadha VP, Huang CY.

Int J Mol Sci. 2015 Nov 24;16(11):27921-30. doi: 10.3390/ijms161126067.


Effects of rhodiola crenulata on mice hearts under severe sleep apnea.

Lai MC, Lin JG, Pai PY, Lai MH, Lin YM, Yeh YL, Cheng SM, Liu YF, Huang CY, Lee SD.

BMC Complement Altern Med. 2015 Jun 25;15:198. doi: 10.1186/s12906-015-0698-0.


Cardio Protective Effects of Lumbrokinase and Dilong on Second-Hand Smoke-Induced Apoptotic Signaling in the Heart of a Rat Model.

Liao HE, Lai CH, Ho TJ, Yeh YL, Jong GP, Kuo WH, Chung LC, Pai PY, Wen SY, Huang CY.

Chin J Physiol. 2015 Jun 30;58(3):188-96. doi: 10.4077/CJP.2015.BAD277.


Long term antihypertensive drug use and prostate cancer risk: A 9-year population-based cohort analysis.

Pai PY, Hsieh VC, Wang CB, Wu HC, Liang WM, Chang YJ, Wu TN.

Int J Cardiol. 2015 Aug 15;193:1-7. doi: 10.1016/j.ijcard.2015.05.042. Epub 2015 May 9.


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