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Items: 1 to 20 of 77

1.

Multi-targeting protein-protein interaction inhibitors: Evolution of macrocyclic ligands with embedded carbohydrates (MECs) to improve selectivity.

Negi A, Reilly CO, Jarikote DV, Zhou J, Murphy PV.

Eur J Med Chem. 2019 Aug 15;176:292-309. doi: 10.1016/j.ejmech.2019.04.064. Epub 2019 May 11.

PMID:
31112891
2.

How altering the modular architecture affects aspects of lectin activity: case study on human galectin-1.

Kutzner TJ, Gabba A, FitzGerald FG, Shilova NV, García Caballero G, Ludwig AK, Manning JC, Knospe C, Kaltner H, Sinowatz F, Murphy PV, Cudic M, Bovin NV, Gabius HJ.

Glycobiology. 2019 Jul 19;29(8):593-607. doi: 10.1093/glycob/cwz034.

PMID:
31091305
3.

N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines.

Zhou J, Negi A, Mirallai SI, Warta R, Herold-Mende C, Carty MP, Ye XS, Murphy PV.

Bioorg Chem. 2019 Mar;84:418-433. doi: 10.1016/j.bioorg.2018.12.003. Epub 2018 Dec 4.

PMID:
30554081
4.

Lewis acid promoted anomerisation of alkyl O- and S-xylo-, arabino- and fucopyranosides.

Doyle LM, Meany FB, Murphy PV.

Carbohydr Res. 2019 Jan 1;471:85-94. doi: 10.1016/j.carres.2018.11.010. Epub 2018 Nov 24.

PMID:
30508660
5.

Ligand design for somatostatin receptor isoforms 4 and 5.

Negi A, Zhou J, Sweeney S, Murphy PV.

Eur J Med Chem. 2019 Feb 1;163:148-159. doi: 10.1016/j.ejmech.2018.11.030. Epub 2018 Nov 17.

PMID:
30503939
6.

Anomer Preferences for Glucuronic and Galacturonic Acid and Derivatives and Influence of Electron-Withdrawing Substituents.

Kerins L, Byrne S, Gabba A, Murphy PV.

J Org Chem. 2018 Aug 3;83(15):7714-7729. doi: 10.1021/acs.joc.8b00610. Epub 2018 Jul 18.

PMID:
29969902
7.

Stereoselective Epimerizations of Glycosyl Thiols.

Doyle LM, O'Sullivan S, Di Salvo C, McKinney M, McArdle P, Murphy PV.

Org Lett. 2017 Nov 3;19(21):5802-5805. doi: 10.1021/acs.orglett.7b02760.

PMID:
29039672
8.

Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design.

Roy R, Cao Y, Kaltner H, Kottari N, Shiao TC, Belkhadem K, André S, Manning JC, Murphy PV, Gabius HJ.

Histochem Cell Biol. 2017 Feb;147(2):285-301. doi: 10.1007/s00418-016-1525-5. Epub 2016 Dec 24.

PMID:
28013366
9.

Multivalent Carbohydrate-Lectin Interactions: How Synthetic Chemistry Enables Insights into Nanometric Recognition.

Roy R, Murphy PV, Gabius HJ.

Molecules. 2016 May 13;21(5). pii: E629. doi: 10.3390/molecules21050629. Review.

10.

Lewis Acid Induced Anomerization of Se-Glycosides. Application to Synthesis of α-Se-GalCer.

McDonagh AW, Mahon MF, Murphy PV.

Org Lett. 2016 Feb 5;18(3):552-5. doi: 10.1021/acs.orglett.5b03591. Epub 2016 Jan 22.

PMID:
26794638
11.

Allylic Azide Rearrangement in Tandem with Huisgen Cycloaddition for Stereoselective Annulation: Synthesis of C-Glycosyl Iminosugars.

Moynihan L, Chadda R, McArdle P, Murphy PV.

Org Lett. 2015 Dec 18;17(24):6226-9. doi: 10.1021/acs.orglett.5b03209. Epub 2015 Dec 9.

PMID:
26650965
12.

Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context.

André S, Kaltner H, Kayser K, Murphy PV, Gabius HJ.

Histochem Cell Biol. 2016 Feb;145(2):185-99. doi: 10.1007/s00418-015-1383-6. Epub 2015 Nov 9.

PMID:
26553286
13.

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.

Lo Re D, Zhou Y, Mucha J, Jones LF, Leahy L, Santocanale C, Krol M, Murphy PV.

Chemistry. 2015 Dec 7;21(50):17993. doi: 10.1002/chem.201504167. Epub 2015 Nov 5.

PMID:
26537992
14.

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.

Lo Re D, Zhou Y, Mucha J, Jones LF, Leahy L, Santocanale C, Krol M, Murphy PV.

Chemistry. 2015 Dec 7;21(50):18109-21. doi: 10.1002/chem.201502861. Epub 2015 Nov 4.

PMID:
26531227
15.

Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.

Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, Smee DF, de la Fuente C, Hoffmann HH, Xue Y, Rice CM, Schols D, Garcia JV, Stuckey JA, Gabius HJ, Al-Hashimi HM, Markovitz DM.

Cell. 2015 Oct 22;163(3):746-58. doi: 10.1016/j.cell.2015.09.056. Epub 2015 Oct 22.

16.

Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor.

Zhou J, Reidy M, O'Reilly C, Jarikote DV, Negi A, Samali A, Szegezdi E, Murphy PV.

Org Lett. 2015 Apr 3;17(7):1672-5. doi: 10.1021/acs.orglett.5b00404. Epub 2015 Mar 16.

PMID:
25774456
17.

Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins.

André S, O'Sullivan S, Koller C, Murphy PV, Gabius HJ.

Org Biomol Chem. 2015 Apr 14;13(14):4190-203. doi: 10.1039/c5ob00048c. Epub 2015 Feb 27.

PMID:
25721929
18.

Lectins: getting familiar with translators of the sugar code.

André S, Kaltner H, Manning JC, Murphy PV, Gabius HJ.

Molecules. 2015 Jan 22;20(2):1788-823. doi: 10.3390/molecules20021788. Review.

19.

Synthesis of migrastatin and its macroketone analogue and in vivo FRAP analysis of the macroketone on E-cadherin dynamics.

Lo Re D, Zhou Y, Nobis M, Anderson KI, Murphy PV.

Chembiochem. 2014 Jul 7;15(10):1459-64. doi: 10.1002/cbic.201402061. Epub 2014 Jun 11.

PMID:
24919421
20.

Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4).

André S, Wang GN, Gabius HJ, Murphy PV.

Carbohydr Res. 2014 May 7;389:25-38. doi: 10.1016/j.carres.2013.12.024. Epub 2014 Jan 11.

PMID:
24698724

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