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Items: 1 to 20 of 32

1.

Advanced Hepatitis C Virus Replication PDE Models within a Realistic Intracellular Geometric Environment.

Knodel MM, Targett-Adams P, Grillo A, Herrmann E, Wittum G.

Int J Environ Res Public Health. 2019 Feb 12;16(3). pii: E513. doi: 10.3390/ijerph16030513.

2.

The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia.

Yehudai D, Liyanage SU, Hurren R, Rizoska B, Albertella M, Gronda M, Jeyaraju DV, Wang X, Barghout SH, MacLean N, Siriwardena TP, Jitkova Y, Targett-Adams P, Schimmer AD.

Haematologica. 2019 May;104(5):963-972. doi: 10.3324/haematol.2018.195172. Epub 2018 Dec 20.

3.

Quantitative Analysis of Hepatitis C NS5A Viral Protein Dynamics on the ER Surface.

Knodel MM, Nägel A, Reiter S, Vogel A, Targett-Adams P, McLauchlan J, Herrmann E, Wittum G.

Viruses. 2018 Jan 8;10(1). pii: E28. doi: 10.3390/v10010028.

4.

3D Spatially Resolved Models of the Intracellular Dynamics of the Hepatitis C Genome Replication Cycle.

Knodel MM, Reiter S, Targett-Adams P, Grillo A, Herrmann E, Wittum G.

Viruses. 2017 Sep 30;9(10). pii: E282. doi: 10.3390/v9100282.

5.

Discovery of β-d-2'-deoxy-2'-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication.

Pinho P, Kalayanov G, Westerlind H, Rosenquist Å, Wähling H, Sund C, Almeida M, Ayesa S, Tejbrant J, Targett-Adams P, Eneroth A, Lindqvist A.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3468-3471. doi: 10.1016/j.bmcl.2017.05.075. Epub 2017 May 26.

PMID:
28622881
6.

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus.

Ansari MA, Pedergnana V, L C Ip C, Magri A, Von Delft A, Bonsall D, Chaturvedi N, Bartha I, Smith D, Nicholson G, McVean G, Trebes A, Piazza P, Fellay J, Cooke G, Foster GR; STOP-HCV Consortium, Hudson E, McLauchlan J, Simmonds P, Bowden R, Klenerman P, Barnes E, Spencer CCA.

Nat Genet. 2017 May;49(5):666-673. doi: 10.1038/ng.3835. Epub 2017 Apr 10.

7.

MAIT cells are activated during human viral infections.

van Wilgenburg B, Scherwitzl I, Hutchinson EC, Leng T, Kurioka A, Kulicke C, de Lara C, Cole S, Vasanawathana S, Limpitikul W, Malasit P, Young D, Denney L; STOP-HCV consortium, Moore MD, Fabris P, Giordani MT, Oo YH, Laidlaw SM, Dustin LB, Ho LP, Thompson FM, Ramamurthy N, Mongkolsapaya J, Willberg CB, Screaton GR, Klenerman P.

Nat Commun. 2016 Jun 23;7:11653. doi: 10.1038/ncomms11653.

8.

Transient replication of a hepatitis C virus genotype 1b replicon chimera encoding NS5A-5B from genotype 3a.

Kylefjord H, Danielsson A, Sedig S, Belda O, Wiktelius D, Vrang L, Targett-Adams P.

J Virol Methods. 2014 Jan;195:156-63. doi: 10.1016/j.jviromet.2013.09.017. Epub 2013 Oct 10.

PMID:
24120570
9.

Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein.

Belda O, Targett-Adams P.

Virus Res. 2012 Dec;170(1-2):1-14. doi: 10.1016/j.virusres.2012.09.007. Epub 2012 Sep 23. Review.

PMID:
23009750
10.

Correlation between NS5A dimerization and hepatitis C virus replication.

Lim PJ, Chatterji U, Cordek D, Sharma SD, Garcia-Rivera JA, Cameron CE, Lin K, Targett-Adams P, Gallay PA.

J Biol Chem. 2012 Aug 31;287(36):30861-73. doi: 10.1074/jbc.M112.376822. Epub 2012 Jul 16.

11.

In-cell click labelling of small molecules to determine subcellular localisation.

Jones LH, Beal D, Selby MD, Everson O, Burslem GM, Dodd P, Millbank J, Tran TD, Wakenhut F, Graham EJ, Targett-Adams P.

J Chem Biol. 2011 Apr;4(2):49-53. doi: 10.1007/s12154-010-0047-1. Epub 2010 Nov 18.

12.

An integrated transcriptomic and meta-analysis of hepatoma cells reveals factors that influence susceptibility to HCV infection.

MacPherson JI, Sidders B, Wieland S, Zhong J, Targett-Adams P, Lohmann V, Backes P, Delpuech-Adams O, Chisari F, Lewis M, Parkinson T, Robertson DL.

PLoS One. 2011;6(10):e25584. doi: 10.1371/journal.pone.0025584. Epub 2011 Oct 25.

13.

Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action.

Targett-Adams P, Graham EJ, Middleton J, Palmer A, Shaw SM, Lavender H, Brain P, Tran TD, Jones LH, Wakenhut F, Stammen B, Pryde D, Pickford C, Westby M.

J Virol. 2011 Jul;85(13):6353-68. doi: 10.1128/JVI.00215-11. Epub 2011 Apr 20.

14.

Colony-forming assays reveal enhanced suppression of hepatitis C virus replication using combinations of direct-acting antivirals.

Graham EJ, Hunt R, Shaw SM, Pickford C, Hammond J, Westby M, Targett-Adams P.

J Virol Methods. 2011 Jun;174(1-2):153-7. doi: 10.1016/j.jviromet.2011.03.031. Epub 2011 Apr 5.

PMID:
21473883
15.

Comparison of U2OS and Huh-7 cells for identifying host factors that affect hepatitis C virus RNA replication.

Jones DM, Domingues P, Targett-Adams P, McLauchlan J.

J Gen Virol. 2010 Sep;91(Pt 9):2238-48. doi: 10.1099/vir.0.022210-0. Epub 2010 May 26.

PMID:
20505011
16.

HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors.

Chatterji U, Lim P, Bobardt MD, Wieland S, Cordek DG, Vuagniaux G, Chisari F, Cameron CE, Targett-Adams P, Parkinson T, Gallay PA.

J Hepatol. 2010 Jul;53(1):50-6. doi: 10.1016/j.jhep.2010.01.041. Epub 2010 Apr 3.

17.

Lipid metabolism and HCV infection.

Targett-Adams P, Boulant S, Douglas MW, McLauchlan J.

Viruses. 2010 May;2(5):1195-217. doi: 10.3390/v2051195. Epub 2010 May 11.

18.

The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A.

Waller H, Chatterji U, Gallay P, Parkinson T, Targett-Adams P.

J Virol Methods. 2010 May;165(2):202-10. doi: 10.1016/j.jviromet.2010.01.020. Epub 2010 Feb 2.

19.

Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein.

Angus AG, Dalrymple D, Boulant S, McGivern DR, Clayton RF, Scott MJ, Adair R, Graham S, Owsianka AM, Targett-Adams P, Li K, Wakita T, McLauchlan J, Lemon SM, Patel AH.

J Gen Virol. 2010 Jan;91(Pt 1):122-32. doi: 10.1099/vir.0.015909-0. Epub 2009 Sep 30.

20.

The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus.

Jones DM, Patel AH, Targett-Adams P, McLauchlan J.

J Virol. 2009 Mar;83(5):2163-77. doi: 10.1128/JVI.01885-08. Epub 2008 Dec 10.

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