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The nitroxide 4-methoxy-tempo inhibits the pathogenesis of dextran sodium sulfate-stimulated experimental colitis.

Chami B, San Gabriel PT, Kum-Jew S, Wang X, Dickerhof N, Dennis JM, Witting PK.

Redox Biol. 2019 Sep 28;28:101333. doi: 10.1016/j.redox.2019.101333. [Epub ahead of print]


Catalase-Like Antioxidant Activity is Unaltered in Hypochlorous Acid Oxidized Horse Heart Myoglobin.

Ahmad G, Chami B, El Kazzi M, Wang X, Moreira MTS, Hamilton N, Maw AM, Hambly TW, Witting PK.

Antioxidants (Basel). 2019 Sep 18;8(9). pii: E414. doi: 10.3390/antiox8090414.


Correction to: Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se-Cu bonding.

Weekley CM, Jeong G, Tierney ME, Hossain F, Maw AM, Shanu A, Harris HH, Witting PK.

J Biol Inorg Chem. 2019 May;24(3):433-435. doi: 10.1007/s00775-019-01652-7.


Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet.

Chami B, Hossain F, Hambly TW, Cai X, Aran R, Fong G, Vellajo A, Martin NJJ, Wang X, Dennis JM, Sharma A, Shihata WA, Chin-Dusting JPF, de Haan JB, Sharland A, Geczy CL, Freedman B, Witting PK.

Front Immunol. 2019 Mar 7;10:380. doi: 10.3389/fimmu.2019.00380. eCollection 2019.


The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets.

Black HD, Xu W, Hortle E, Robertson SI, Britton WJ, Kaur A, New EJ, Witting PK, Chami B, Oehlers SH.

Free Radic Biol Med. 2019 May 1;135:157-166. doi: 10.1016/j.freeradbiomed.2019.03.010. Epub 2019 Mar 14.


NFκB Inhibition Mitigates Serum Amyloid A-Induced Pro-Atherogenic Responses in Endothelial Cells and Leukocyte Adhesion and Adverse Changes to Endothelium Function in Isolated Aorta.

Vallejo A, Chami B, Dennis JM, Simone M, Ahmad G, Abdo AI, Sharma A, Shihata WA, Martin N, Chin-Dusting JPF, de Haan JB, Witting PK.

Int J Mol Sci. 2018 Dec 28;20(1). pii: E105. doi: 10.3390/ijms20010105.


Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase.

Lim YJ, Foo TC, Yeung AWS, Tu X, Ma Y, Hawkins CL, Witting PK, Jameson GNL, Terentis AC, Thomas SR.

Biochemistry. 2019 Feb 19;58(7):974-986. doi: 10.1021/acs.biochem.8b01231. Epub 2019 Jan 23.


Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y.

Escobar SJM, Fong GM, Winnischofer SMB, Simone M, Munoz L, Dennis JM, Rocha MEM, Witting PK.

Chem Biol Interact. 2019 Feb 1;299:77-87. doi: 10.1016/j.cbi.2018.11.022. Epub 2018 Nov 28.


Corrigendum to "Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis" [Free Radic. Biol. Med. 52(9) (2012) 1918-1928].

Groebler LK, Wang XS, Kim HB, Shanu A, Hossain F, McMahon AC, Witting PK.

Free Radic Biol Med. 2018 Dec;129:621-622. doi: 10.1016/j.freeradbiomed.2018.09.006. Epub 2018 Sep 20. No abstract available.


Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease.

Youssef P, Chami B, Lim J, Middleton T, Sutherland GT, Witting PK.

Sci Rep. 2018 Aug 1;8(1):11553. doi: 10.1038/s41598-018-29770-3.


Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing.

Alghamdi OA, King N, Andronicos NM, Jones GL, Chami B, Witting PK, Moens PDJ.

Mol Cell Biochem. 2019 Feb;452(1-2):71-82. doi: 10.1007/s11010-018-3413-x. Epub 2018 Jul 17.


Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease.

Chami B, Martin NJJ, Dennis JM, Witting PK.

Arch Biochem Biophys. 2018 May 1;645:61-71. doi: 10.1016/ Epub 2018 Mar 13. Review.


Protective Role for Antioxidants in Acute Kidney Disease.

Dennis JM, Witting PK.

Nutrients. 2017 Jul 7;9(7). pii: E718. doi: 10.3390/nu9070718. Review.


Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease.

Gotsbacher MP, Telfer TJ, Witting PK, Double KL, Finkelstein DI, Codd R.

Metallomics. 2017 Jul 19;9(7):852-864. doi: 10.1039/c7mt00039a.


Neutrophils recruited to the myocardium after acute experimental myocardial infarct generate hypochlorous acid that oxidizes cardiac myoglobin.

Wang XS, Kim HB, Szuchman-Sapir A, McMahon A, Dennis JM, Witting PK.

Arch Biochem Biophys. 2016 Dec 15;612:103-114. doi: 10.1016/ Epub 2016 Oct 24.


Measuring redox-active species in cells and tissues. Focus on "A case of mistaken identity: are reactive oxygen species actually reactive sulfide species?".

Witting PK.

Am J Physiol Regul Integr Comp Physiol. 2016 Apr 1;310(7):R547-8. doi: 10.1152/ajpregu.00049.2016. Epub 2016 Feb 17. No abstract available.


Serum amyloid A receptor blockade and incorporation into high-density lipoprotein modulates its pro-inflammatory and pro-thrombotic activities on vascular endothelial cells.

Chami B, Barrie N, Cai X, Wang X, Paul M, Morton-Chandra R, Sharland A, Dennis JM, Freedman SB, Witting PK.

Int J Mol Sci. 2015 May 15;16(5):11101-24. doi: 10.3390/ijms160511101.


Effects of 8 weeks of CPAP on lipid-based oxidative markers in obstructive sleep apnea: a randomized trial.

Sivam S, Witting PK, Hoyos CM, Maw AM, Yee BJ, Grunstein RR, Phillips CL.

J Sleep Res. 2015 Jun;24(3):339-45. doi: 10.1111/jsr.12271. Epub 2014 Dec 22.


XAS studies of Se speciation in selenite-fed rats.

Weekley CM, Aitken JB, Witting PK, Harris HH.

Metallomics. 2014 Dec;6(12):2193-203. doi: 10.1039/c4mt00227j. Epub 2014 Nov 3.

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