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Items: 1 to 20 of 160

1.

The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis.

Cappoen D, Torfs E, Meiresonne T, Claes P, Semina E, Holvoet F, de Macedo MB, Cools F, Piller T, Matheeussen A, Van Calster K, Caljon G, Delputte P, Maes L, Neyrolles O, De Kimpe N, Mangelinckx S, Cos P.

Eur J Med Chem. 2019 Jul 19;181:111549. doi: 10.1016/j.ejmech.2019.07.052. [Epub ahead of print]

PMID:
31376569
2.

Opportunities for Overcoming Mycobacterium tuberculosis Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy.

Torfs E, Piller T, Cos P, Cappoen D.

Int J Mol Sci. 2019 Jun 12;20(12). pii: E2868. doi: 10.3390/ijms20122868. Review.

3.

Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from Phania matricarioides (Spreng.) Griseb.

Gutiérrez YI, Scull R, Villa A, Satyal P, Cos P, Monzote L, Setzer WN.

Molecules. 2019 Apr 24;24(8). pii: E1615. doi: 10.3390/molecules24081615.

4.

Characterization of the role of N-glycosylation sites in the respiratory syncytial virus fusion protein in virus replication, syncytium formation and antigenicity.

Leemans A, Boeren M, Van der Gucht W, Martinet W, Caljon G, Maes L, Cos P, Delputte P.

Virus Res. 2019 Jun;266:58-68. doi: 10.1016/j.virusres.2019.04.006. Epub 2019 Apr 17.

PMID:
31004621
5.

Non-Thermal Plasma as a Unique Delivery System of Short-Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells.

Lin A, Gorbanev Y, De Backer J, Van Loenhout J, Van Boxem W, Lemière F, Cos P, Dewilde S, Smits E, Bogaerts A.

Adv Sci (Weinh). 2019 Jan 28;6(6):1802062. doi: 10.1002/advs.201802062. eCollection 2019 Mar 20.

6.

In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei.

Rojas Vargas JA, López AG, Pérez Y, Cos P, Froeyen M.

Parasitol Res. 2019 May;118(5):1533-1548. doi: 10.1007/s00436-019-06206-z. Epub 2019 Mar 23.

PMID:
30903349
7.

Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents.

Courtens C, Risseeuw M, Caljon G, Maes L, Cos P, Martin A, Van Calenbergh S.

Bioorg Med Chem Lett. 2019 May 15;29(10):1232-1235. doi: 10.1016/j.bmcl.2019.03.009. Epub 2019 Mar 7.

PMID:
30879839
8.

Phosphonodiamidate prodrugs of N-alkoxy analogs of a fosmidomycin surrogate as antimalarial and antitubercular agents.

Courtens C, Risseeuw M, Caljon G, Cos P, Martin A, Van Calenbergh S.

Bioorg Med Chem Lett. 2019 May 1;29(9):1051-1053. doi: 10.1016/j.bmcl.2019.03.008. Epub 2019 Mar 7.

PMID:
30857749
9.

Antimicrobial activity of leaf extracts and isolated constituents of Croton linearis.

García Díaz J, Tuenter E, Escalona Arranz JC, Llauradó Maury G, Cos P, Pieters L.

J Ethnopharmacol. 2019 May 23;236:250-257. doi: 10.1016/j.jep.2019.01.049. Epub 2019 Mar 5.

PMID:
30849504
10.

Optimization and Characterization of a Galleria mellonella Larval Infection Model for Virulence Studies and the Evaluation of Therapeutics Against Streptococcus pneumoniae.

Cools F, Torfs E, Aizawa J, Vanhoutte B, Maes L, Caljon G, Delputte P, Cappoen D, Cos P.

Front Microbiol. 2019 Feb 21;10:311. doi: 10.3389/fmicb.2019.00311. eCollection 2019.

11.

Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG.

Allonsius CN, Vandenheuvel D, Oerlemans EFM, Petrova MI, Donders GGG, Cos P, Delputte P, Lebeer S.

Sci Rep. 2019 Feb 27;9(1):2900. doi: 10.1038/s41598-019-39625-0.

12.

Synthesis and antitubercular activity of 1- and 3-substituted benzo[g]isoquinoline-5,10-diones.

Smets RJ, Torfs E, Lemière F, Cos P, Cappoen D, Abbaspour Tehrani K.

Org Biomol Chem. 2019 Mar 13;17(11):2923-2939. doi: 10.1039/c8ob02690d.

PMID:
30801604
13.

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

Cimanga RK, Nsaka SL, Tshodi ME, Mbamu BM, Kikweta CM, Makila FB, Cos P, Maes L, Vlietinck AJ, Exarchou V, Tuenter E, Pieters L.

J Ethnopharmacol. 2019 Oct 5;242:111736. doi: 10.1016/j.jep.2019.02.019. Epub 2019 Feb 11.

PMID:
30763695
14.

HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.

Zarev Y, Foubert K, Cos P, Maes L, Elgorashi E, Apers S, Ionkova I, Pieters L.

Nat Prod Res. 2019 Jan 3:1-4. doi: 10.1080/14786419.2018.1539976. [Epub ahead of print]

PMID:
30602319
15.

Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain.

Eberhardt E, Bulté D, Van Bockstal L, Van den Kerkhof M, Cos P, Delputte P, Hendrickx S, Maes L, Caljon G.

J Antimicrob Chemother. 2019 Feb 1;74(2):395-406. doi: 10.1093/jac/dky450.

PMID:
30412253
16.

Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents.

Courtens C, Risseeuw M, Caljon G, Cos P, Van Calenbergh S.

ACS Med Chem Lett. 2018 Sep 11;9(10):986-989. doi: 10.1021/acsmedchemlett.8b00223. eCollection 2018 Oct 11.

PMID:
30344904
17.

Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function.

Mannaerts D, Faes E, Cos P, Briedé JJ, Gyselaers W, Cornette J, Gorbanev Y, Bogaerts A, Spaanderman M, Van Craenenbroeck E, Jacquemyn Y.

PLoS One. 2018 Sep 11;13(9):e0202919. doi: 10.1371/journal.pone.0202919. eCollection 2018.

18.

Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization.

Leemans A, Boeren M, Van der Gucht W, Pintelon I, Roose K, Schepens B, Saelens X, Bailey D, Martinet W, Caljon G, Maes L, Cos P, Delputte P.

Viruses. 2018 Aug 14;10(8). pii: E426. doi: 10.3390/v10080426.

19.

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, Cantón E, Coenye T, Cos P, Cowen LE, Edgerton M, Espinel-Ingroff A, Filler SG, Ghannoum M, Gow NAR, Haas H, Jabra-Rizk MA, Johnson EM, Lockhart SR, Lopez-Ribot JL, Maertens J, Munro CA, Nett JE, Nobile CJ, Pfaller MA, Ramage G, Sanglard D, Sanguinetti M, Spriet I, Verweij PE, Warris A, Wauters J, Yeaman MR, Zaat SAJ, Thevissen K.

Microb Cell. 2018 Jun 14;5(7):300-326. doi: 10.15698/mic2018.07.638. Review.

20.

Efficacy of Four Solanum spp. Extracts in an Animal Model of Cutaneous Leishmaniasis.

Cos P, Janssens J, Piñón A, Cuesta-Rubio O, Yglesias-Rivera A, Díaz-García A, Vilegas W, Monzote L.

Medicines (Basel). 2018 Jun 5;5(2). pii: E49. doi: 10.3390/medicines5020049.

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