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Items: 1 to 20 of 186

1.

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels.

Jin AH, Cristofori-Armstrong B, Rash LD, Román-González SA, Espinosa RA, Lewis RJ, Alewood PF, Vetter I.

Biochem Pharmacol. 2019 Jun;164:342-348. doi: 10.1016/j.bcp.2019.04.025. Epub 2019 Apr 24.

PMID:
31028742
2.

Investigation of the estuarine stonefish (Synanceia horrida) venom composition.

Ziegman R, Undheim EAB, Baillie G, Jones A, Alewood PF.

J Proteomics. 2019 Jun 15;201:12-26. doi: 10.1016/j.jprot.2019.04.002. Epub 2019 Apr 4.

PMID:
30953730
3.

Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen.

Mueller A, Starobova H, Morgan M, Dekan Z, Cheneval O, Schroeder CI, Alewood PF, Deuis JR, Vetter I.

Pain. 2019 Mar 21. doi: 10.1097/j.pain.0000000000001567. [Epub ahead of print]

PMID:
30908355
4.

Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis.

Jin AH, Dutertre S, Dutt M, Lavergne V, Jones A, Lewis RJ, Alewood PF.

Mar Drugs. 2019 Mar 19;17(3). pii: E177. doi: 10.3390/md17030177.

5.

'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency.

Ziegman R, Brust A, Jha P, Cardoso FC, Lewis RJ, Alewood PF.

Mar Drugs. 2019 Mar 14;17(3). pii: E165. doi: 10.3390/md17030165.

6.

Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa.

Dutt M, Dutertre S, Jin AH, Lavergne V, Alewood PF, Lewis RJ.

Mar Drugs. 2019 Jan 21;17(1). pii: E71. doi: 10.3390/md17010071.

7.

Vampire Venom: Vasodilatory Mechanisms of Vampire Bat (Desmodus rotundus) Blood Feeding.

Kakumanu R, Hodgson WC, Ravi R, Alagon A, Harris RJ, Brust A, Alewood PF, Kemp-Harper BK, Fry BG.

Toxins (Basel). 2019 Jan 8;11(1). pii: E26. doi: 10.3390/toxins11010026.

8.

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.

9.

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.

Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF.

Biomedicines. 2018 Aug 28;6(3). pii: E90. doi: 10.3390/biomedicines6030090.

10.

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target.

Ma L, Chin YKY, Dekan Z, Herzig V, Chow CY, Heighway J, Lam SW, Guillemin GJ, Alewood PF, King GF.

Biochem Pharmacol. 2018 Dec;158:60-72. doi: 10.1016/j.bcp.2018.08.038. Epub 2018 Aug 25.

PMID:
30149017
11.

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold.

Madio B, Peigneur S, Chin YKY, Hamilton BR, Henriques ST, Smith JJ, Cristofori-Armstrong B, Dekan Z, Boughton BA, Alewood PF, Tytgat J, King GF, Undheim EAB.

Cell Mol Life Sci. 2018 Dec;75(24):4511-4524. doi: 10.1007/s00018-018-2897-6. Epub 2018 Aug 14.

PMID:
30109357
12.

Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation.

Ikonomopoulou MP, Fernandez-Rojo MA, Pineda SS, Cabezas-Sainz P, Winnen B, Morales RAV, Brust A, Sánchez L, Alewood PF, Ramm GA, Miles JJ, King GF.

Sci Rep. 2018 Aug 1;8(1):11519. doi: 10.1038/s41598-018-29826-4.

13.

Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter.

Brust A, Wang CA, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5203. doi: 10.1002/anie.201803138. No abstract available.

PMID:
29701320
14.

Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells.

Fernandez-Rojo MA, Deplazes E, Pineda SS, Brust A, Marth T, Wilhelm P, Martel N, Ramm GA, Mancera RL, Alewood PF, Woods GM, Belov K, Miles JJ, King GF, Ikonomopoulou MP.

Cell Death Discov. 2018 Feb 14;4:19. doi: 10.1038/s41420-018-0030-0. eCollection 2018 Dec.

15.

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.

Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Sci Signal. 2017 Dec 5;10(508). pii: eaan3398. doi: 10.1126/scisignal.aan3398.

16.

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity.

Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14973-14976. doi: 10.1002/anie.201708927. Epub 2017 Oct 24.

PMID:
28984021
17.

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.

18.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

19.

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ.

Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.

20.

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities.

Dekan Z, Headey SJ, Scanlon M, Baldo BA, Lee TH, Aguilar MI, Deuis JR, Vetter I, Elliott AG, Amado M, Cooper MA, Alewood D, Alewood PF.

Angew Chem Int Ed Engl. 2017 Jul 10;56(29):8495-8499. doi: 10.1002/anie.201703360. Epub 2017 Jun 13.

PMID:
28513074

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