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A computational study of regioselectivity in aluminum hydride ring-opening of cis- and trans-4-t-butyl and 3-methylcyclohexene oxides.

Deora N, Carlier PR.

Org Biomol Chem. 2019 Sep 25;17(37):8628-8635. doi: 10.1039/c9ob01675a.


Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1H-1H coupling constants.

Cagašová K, Ghavami M, Yao ZK, Carlier PR.

Org Biomol Chem. 2019 Jul 21;17(27):6687-6698. doi: 10.1039/c9ob01139k. Epub 2019 Jun 24.


Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates.

Mutunga JM, Ma M, Chen QH, Hartsel JA, Wong DM, Ding S, Totrov M, Carlier PR, Bloomquist JR.

Int J Environ Res Public Health. 2019 Apr 28;16(9). pii: E1500. doi: 10.3390/ijerph16091500.


Toxicity, mode of action, and synergist potential of flonicamid against mosquitoes.

Taylor-Wells J, Gross AD, Jiang S, Demares F, Clements JS, Carlier PR, Bloomquist JR.

Pestic Biochem Physiol. 2018 Oct;151:3-9. doi: 10.1016/j.pestbp.2018.06.004. Epub 2018 Jun 15.


Select β- and γ-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

Carlier PR, Chen QH, Verma A, Wong DM, Mutunga JM, Müller J, Islam R, Shimozono AM, Tong F, Li J, Totrov M, Bloomquist JR.

Pestic Biochem Physiol. 2018 Oct;151:32-39. doi: 10.1016/j.pestbp.2018.02.003. Epub 2018 Feb 13.


Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice.

Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, Naman CB, Mak S, Carlier PR, Cui W, Han Y.

Front Cell Neurosci. 2018 Nov 7;12:396. doi: 10.3389/fncel.2018.00396. eCollection 2018.


Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance.

Cheung J, Mahmood A, Kalathur R, Liu L, Carlier PR.

Structure. 2018 Jan 2;26(1):130-136.e2. doi: 10.1016/j.str.2017.11.021. Epub 2017 Dec 21.


N'-mono- and N, N'-diacyl derivatives of benzyl and arylhydrazines as contact insecticides against adult Anopheles gambiae.

Clements JS 2nd, Islam R, Sun B, Tong F, Gross AD, Bloomquist JR, Carlier PR.

Pestic Biochem Physiol. 2017 Nov;143:33-38. doi: 10.1016/j.pestbp.2017.10.001. Epub 2017 Oct 7.


Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs.

Ghavami M, Merino EF, Yao ZK, Elahi R, Simpson ME, Fernández-Murga ML, Butler JH, Casasanta MA, Krai PM, Totrov MM, Slade DJ, Carlier PR, Cassera MB.

ACS Infect Dis. 2018 Apr 13;4(4):549-559. doi: 10.1021/acsinfecdis.7b00159. Epub 2017 Nov 7.


Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae.

Han Q, Wong DM, Robinson H, Ding H, Lam PCH, Totrov MM, Carlier PR, Li J.

Insect Sci. 2018 Aug;25(4):721-724. doi: 10.1111/1744-7917.12450. Epub 2017 May 8. No abstract available.


Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito.

Carlier PR, Bloomquist JR, Totrov M, Li J.

Curr Med Chem. 2017;24(27):2946-2958. doi: 10.2174/0929867324666170206130024. Review.


Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae.

Mutunga JM, Chen QH, Wong DM, Lam PC, Li J, Totrov MM, Gross AD, Carlier PR, Bloomquist JR.

Chimia (Aarau). 2016 Oct;70(10):704-708.


Parallel inhibition of amino acid efflux and growth of erythrocytic Plasmodium falciparum by mefloquine and non-piperidine analogs: Implication for the mechanism of antimalarial action.

Ghavami M, Dapper CH, Dalal S, Holzschneider K, Klemba M, Carlier PR.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4846-4850. doi: 10.1016/j.bmcl.2016.08.005. Epub 2016 Aug 3.


Toxicology of potassium channel-directed compounds in mosquitoes.

Larson NR, Carlier PR, Gross AD, Islam RM, Ma M, Sun B, Totrov MM, Yadav R, Bloomquist JR.

Neurotoxicology. 2017 May;60:214-223. doi: 10.1016/j.neuro.2016.05.021. Epub 2016 Jun 1.


Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.

Camerino E, Wong DM, Tong F, Körber F, Gross AD, Islam R, Viayna E, Mutunga JM, Li J, Totrov MM, Bloomquist JR, Carlier PR.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4405-11. doi: 10.1016/j.bmcl.2015.09.019. Epub 2015 Sep 8.


Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae.

Mutunga JM, Anderson TD, Craft DT, Gross AD, Swale DR, Tong F, Wong DM, Carlier PR, Bloomquist JR.

Pestic Biochem Physiol. 2015 Jun;121:116-21. doi: 10.1016/j.pestbp.2015.03.001. Epub 2015 Mar 9.


Structural genomics for drug design against the pathogen Coxiella burnetii.

Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD.

Proteins. 2015 Dec;83(12):2124-36. doi: 10.1002/prot.24841. Epub 2015 Oct 6.


Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies.

Yao ZK, Krai PM, Merino EF, Simpson ME, Slebodnick C, Cassera MB, Carlier PR.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9. doi: 10.1016/j.bmcl.2015.02.020. Epub 2015 Feb 21.


3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.

Verma A, Wong DM, Islam R, Tong F, Ghavami M, Mutunga JM, Slebodnick C, Li J, Viayna E, Lam PC, Totrov MM, Bloomquist JR, Carlier PR.

Bioorg Med Chem. 2015 Mar 15;23(6):1321-40. doi: 10.1016/j.bmc.2015.01.026. Epub 2015 Jan 22.


Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant.

Temeyer KB, Tong F, Totrov MM, Tuckow AP, Chen QH, Carlier PR, Pérez de León AA, Bloomquist JR.

Parasit Vectors. 2014 Dec 10;7:577. doi: 10.1186/s13071-014-0577-4.

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