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Items: 20

1.

The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues.

Pisaneschi F, Lin YH, Leonard PG, Satani N, Yan VC, Hammoudi N, Raghavan S, Link TM, K Georgiou D, Czako B, Muller FL.

Molecules. 2019 Jul 9;24(13). pii: E2510. doi: 10.3390/molecules24132510.

2.

The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding.

Tsoi PS, Choi KJ, Leonard PG, Sizovs A, Moosa MM, MacKenzie KR, Ferreon JC, Ferreon ACM.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12590-12593. doi: 10.1002/anie.201706769. Epub 2017 Sep 5.

PMID:
28833982
3.

An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State.

Davlieva M, Tovar-Yanez A, DeBruler K, Leonard PG, Zianni MR, Arias CA, Shamoo Y.

J Mol Biol. 2016 Nov 6;428(22):4503-4519. doi: 10.1016/j.jmb.2016.09.016. Epub 2016 Sep 23.

4.

SF2312 is a natural phosphonate inhibitor of enolase.

Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR 4th, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL.

Nat Chem Biol. 2016 Dec;12(12):1053-1058. doi: 10.1038/nchembio.2195. Epub 2016 Oct 10.

5.

Corrigendum: Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.

Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR 4th, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC.

Nat Med. 2016 Oct 6;22(10):1192. doi: 10.1038/nm1016-1192c. No abstract available.

PMID:
27711065
6.

Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.

Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR 4th, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC.

Nat Med. 2016 Feb;22(2):194-201. doi: 10.1038/nm.4032. Epub 2016 Jan 18. Erratum in: Nat Med. 2016 Oct 6;22(10 ):1192.

7.

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors.

Vohidov F, Knudsen SE, Leonard PG, Ohata J, Wheadon MJ, Popp BV, Ladbury JE, Ball ZT.

Chem Sci. 2015 Aug 1;6(8):4778-4783. doi: 10.1039/c5sc01602a. Epub 2015 Jun 3.

8.

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.

Davlieva M, Shi Y, Leonard PG, Johnson TA, Zianni MR, Arias CA, Ladbury JE, Shamoo Y.

Nucleic Acids Res. 2015 May 19;43(9):4758-73. doi: 10.1093/nar/gkv321. Epub 2015 Apr 19.

9.

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.

Poncet-Montange G, Zhan Y, Bardenhagen JP, Petrocchi A, Leo E, Shi X, Lee GR 4th, Leonard PG, Geck Do MK, Cardozo MG, Andersen JN, Palmer WS, Jones P, Ladbury JE.

Biochem J. 2015 Mar 1;466(2):337-46. doi: 10.1042/BJ20140933.

10.

The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.

Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P.

PLoS One. 2014 Jun 17;9(6):e99440. doi: 10.1371/journal.pone.0099440. eCollection 2014.

11.

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.

Aramini JM, Hamilton K, Ma LC, Swapna GVT, Leonard PG, Ladbury JE, Krug RM, Montelione GT.

Structure. 2014 Apr 8;22(4):515-525. doi: 10.1016/j.str.2014.01.010. Epub 2014 Feb 27.

12.

FAK dimerization controls its kinase-dependent functions at focal adhesions.

Brami-Cherrier K, Gervasi N, Arsenieva D, Walkiewicz K, Boutterin MC, Ortega A, Leonard PG, Seantier B, Gasmi L, Bouceba T, Kadaré G, Girault JA, Arold ST.

EMBO J. 2014 Feb 18;33(4):356-70. doi: 10.1002/embj.201386399. Epub 2014 Jan 30.

13.

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.

Timsah Z, Ahmed Z, Lin CC, Melo FA, Stagg LJ, Leonard PG, Jeyabal P, Berrout J, O'Neil RG, Bogdanov M, Ladbury JE.

Nat Struct Mol Biol. 2014 Feb;21(2):180-8. doi: 10.1038/nsmb.2752. Epub 2014 Jan 19.

PMID:
24440983
14.

Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation.

Leonard PG, Golemi-Kotra D, Stock AM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8525-30. doi: 10.1073/pnas.1302819110. Epub 2013 May 6.

15.

Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding.

Leonard PG, Bezar IF, Sidote DJ, Stock AM.

Biochemistry. 2012 Dec 18;51(50):10035-43. doi: 10.1021/bi3011785. Epub 2012 Dec 3.

16.

Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region.

Ertekin A, Aramini JM, Rossi P, Leonard PG, Janjua H, Xiao R, Maglaqui M, Lee HW, Prestegard JH, Montelione GT.

J Biol Chem. 2012 May 11;287(20):16541-9. doi: 10.1074/jbc.M112.343863. Epub 2012 Mar 14.

17.

Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus.

Guan R, Ma LC, Leonard PG, Amer BR, Sridharan H, Zhao C, Krug RM, Montelione GT.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13468-73. doi: 10.1073/pnas.1107032108. Epub 2011 Aug 1.

18.

H-NS forms a superhelical protein scaffold for DNA condensation.

Arold ST, Leonard PG, Parkinson GN, Ladbury JE.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15728-32. doi: 10.1073/pnas.1006966107. Epub 2010 Aug 23.

19.

The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.

Leonard PG, Parkinson GN, Gor J, Perkins SJ, Ladbury JE.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):421-5. doi: 10.1107/S1744309110004574. Epub 2010 Mar 31.

20.

Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria.

Leonard PG, Ono S, Gor J, Perkins SJ, Ladbury JE.

Mol Microbiol. 2009 Jul;73(2):165-79. doi: 10.1111/j.1365-2958.2009.06754.x. Epub 2009 Jun 8.

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