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Items: 1 to 20 of 191

1.

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase.

Kiss LE, Beliaev A, Ferreira HS, Rosa CP, Bonifácio MJ, Loureiro AI, Pires NM, Palma PN, Soares-da-Silva P.

ChemMedChem. 2018 Aug 16. doi: 10.1002/cmdc.201800393. [Epub ahead of print]

PMID:
30113139
2.

Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells.

Holtkamp D, Opitz T, Hebeisen S, Soares-da-Silva P, Beck H.

Epilepsia. 2018 Aug;59(8):1492-1506. doi: 10.1111/epi.14504. Epub 2018 Jun 28.

PMID:
29953587
3.

Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy.

Beckonert NM, Opitz T, Pitsch J, Soares da Silva P, Beck H.

J Neurosci. 2018 Jun 13;38(24):5596-5605. doi: 10.1523/JNEUROSCI.0640-18.2018. Epub 2018 May 22.

PMID:
29789377
4.

Effectiveness of opicapone and switching from entacapone in fluctuating Parkinson disease.

Ferreira JJ, Lees AJ, Poewe W, Rascol O, Rocha JF, Keller B, Soares-da-Silva P.

Neurology. 2018 May 22;90(21):e1849-e1857. doi: 10.1212/WNL.0000000000005557. Epub 2018 Apr 25.

PMID:
29695590
5.

Eslicarbazepine acetate exposure in pregnant women with epilepsy.

Costa R, Magalhães LM, Graça J, Vieira M, Gama H, Moreira J, Rocha JF, Soares-da-Silva P.

Seizure. 2018 May;58:72-74. doi: 10.1016/j.seizure.2018.04.007. Epub 2018 Apr 10.

6.

Antihypertensive effect of etamicastat in dopamine D2 receptor-deficient mice.

Armando I, Asico LD, Wang X, Jones JE, Serrão MP, Cuevas S, Grandy DK, Soares-da-Silva P, Jose PA.

Hypertens Res. 2018 Jul;41(7):489-498. doi: 10.1038/s41440-018-0041-5. Epub 2018 Apr 13.

PMID:
29654295
7.

Response: Comparing the dosages of lacosamide, eslicarbazepine acetate, and controlled-release carbamazepine in noninferiority epilepsy monotherapy trials: How much "fair" is "fair".

Trinka E, Rocha JF, Soares-da-Silva P.

Epilepsia. 2018 Apr;59(4):900-901. doi: 10.1111/epi.14062. No abstract available.

PMID:
29604066
8.

Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs.

Mintzer S, Wechsler RT, Rogin JB, Gidal BE, Schwab M, Ben-Menachem E, Carreño M, da Silva PS, Moreira J, Li Y, Blum D, Grinnell T.

Epilepsy Res. 2018 Mar;141:83-89. doi: 10.1016/j.eplepsyres.2018.02.001. Epub 2018 Feb 9.

9.

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.

Bicker J, Alves G, Fortuna A, Soares-da-Silva P, Falcão A.

Eur J Pharm Sci. 2018 May 30;117:35-40. doi: 10.1016/j.ejps.2018.02.006. Epub 2018 Feb 8.

PMID:
29428540
10.

Efficacy and safety of eslicarbazepine acetate versus controlled-release carbamazepine monotherapy in newly diagnosed epilepsy: A phase III double-blind, randomized, parallel-group, multicenter study.

Trinka E, Ben-Menachem E, Kowacs PA, Elger C, Keller B, Löffler K, Rocha JF, Soares-da-Silva P.

Epilepsia. 2018 Feb;59(2):479-491. doi: 10.1111/epi.13993. Epub 2018 Jan 25.

PMID:
29369348
11.

Influence of titration schedule and maintenance dose on the tolerability of adjunctive eslicarbazepine acetate: An integrated analysis of three randomized placebo-controlled trials.

Krauss G, Biton V, Harvey JH, Elger C, Trinka E, Soares da Silva P, Gama H, Cheng H, Grinnell T, Blum D.

Epilepsy Res. 2018 Jan;139:1-8. doi: 10.1016/j.eplepsyres.2017.10.021. Epub 2017 Nov 4.

12.

Pooled efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Data from four double-blind placebo-controlled pivotal phase III clinical studies.

Elger C, Koepp M, Trinka E, Villanueva V, Chaves J, Ben-Menachen E, Kowacs PA, Gil-Nagel A, Moreira J, Gama H, Rocha JF, Soares-da-Silva P.

CNS Neurosci Ther. 2017 Dec;23(12):961-972. doi: 10.1111/cns.12765. Epub 2017 Oct 13.

13.

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors.

Bicker J, Fortuna A, Alves G, Soares-da-Silva P, Falcão A.

Drug Metab Dispos. 2017 Dec;45(12):1282-1291. doi: 10.1124/dmd.117.077883. Epub 2017 Sep 15.

PMID:
28916530
14.

The effect of PRR ligands on the membrane potential of intestinal epithelial cells.

Magalhães D, Soares-da-Silva P, Magro F.

Pharmacol Rep. 2017 Oct;69(5):978-984. doi: 10.1016/j.pharep.2017.04.010. Epub 2017 Apr 23.

PMID:
28837901
15.

Safety Profile of Eslicarbazepine Acetate as Add-On Therapy in Adults with Refractory Focal-Onset Seizures: From Clinical Studies to 6 Years of Post-Marketing Experience.

Gama H, Vieira M, Costa R, Graça J, Magalhães LM, Soares-da-Silva P.

Drug Saf. 2017 Dec;40(12):1231-1240. doi: 10.1007/s40264-017-0576-4. Review.

16.

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

Gonçalves D, Alves G, Fortuna A, Bonifácio MJ, Soares-da-Silva P, Falcão A.

Neuropharmacology. 2017 Oct;125:146-155. doi: 10.1016/j.neuropharm.2017.07.019. Epub 2017 Jul 19.

PMID:
28734868
17.

Concerns Regarding Opicapone as Adjunct to Levodopa Therapy-Reply.

Lees AJ, Rocha JF, Soares-da-Silva P.

JAMA Neurol. 2017 Jul 1;74(7):873. doi: 10.1001/jamaneurol.2017.0726. No abstract available.

PMID:
28531266
18.

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.

Gonçalves D, Alves G, Fortuna A, Soares-da-Silva P, Falcão A.

Toxicol Appl Pharmacol. 2017 May 15;323:9-15. doi: 10.1016/j.taap.2017.03.013. Epub 2017 Mar 16.

PMID:
28322896
19.

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial.

Lees AJ, Ferreira J, Rascol O, Poewe W, Rocha JF, McCrory M, Soares-da-Silva P; BIPARK-2 Study Investigators.

JAMA Neurol. 2017 Feb 1;74(2):197-206. doi: 10.1001/jamaneurol.2016.4703.

PMID:
28027332
20.

Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics.

Rocha JF, Sicard É, Fauchoux N, Falcão A, Santos A, Loureiro AI, Pinto R, Bonifácio MJ, Nunes T, Almeida L, Soares-da-Silva P.

Br J Clin Pharmacol. 2017 Mar;83(3):540-553. doi: 10.1111/bcp.13156. Epub 2016 Dec 2.

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