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Items: 1 to 20 of 48

1.

Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies.

Couly F, Harari M, Dubouilh-Benard C, Bailly L, Petit E, Diharce J, Bonnet P, Meijer L, Fruit C, Besson T.

Molecules. 2018 Aug 29;23(9). pii: E2181. doi: 10.3390/molecules23092181.

2.

Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors.

Oyallon B, Brachet-Botineau M, Logé C, Bonnet P, Souab M, Robert T, Ruchaud S, Bach S, Berthelot P, Gouilleux F, Viaud-Massuard MC, Denevault-Sabourin C.

Eur J Med Chem. 2018 Jun 25;154:101-109. doi: 10.1016/j.ejmech.2018.04.056. Epub 2018 May 11.

PMID:
29778892
3.

PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials.

Carles F, Bourg S, Meyer C, Bonnet P.

Molecules. 2018 Apr 15;23(4). pii: E908. doi: 10.3390/molecules23040908.

4.

Enhanced Molecular Dynamics Methods Applied to Drug Design Projects.

Ziada S, Braka A, Diharce J, Aci-Sèche S, Bonnet P.

Methods Mol Biol. 2018;1762:403-426. doi: 10.1007/978-1-4939-7756-7_20.

PMID:
29594783
5.

The Value Chain Approach in One Health: Conceptual Framing and Focus on Present Applications and Challenges.

Antoine-Moussiaux N, Peyre M, Bonnet P, Bebay C, Bengoumi M, Tripodi A.

Front Vet Sci. 2017 Dec 11;4:206. doi: 10.3389/fvets.2017.00206. eCollection 2017.

6.

Thermodynamic enantioseparation behavior of phenylthiohydantoin-amino acid derivatives in supercritical fluid chromatography on polysaccharide chiral stationary phases.

Khater S, Canault B, Azzimani T, Bonnet P, West C.

J Sep Sci. 2018 Mar;41(6):1450-1459. doi: 10.1002/jssc.201701196. Epub 2018 Jan 10.

PMID:
29266870
7.

Advocacy for identifying certain animal diseases as "neglected".

Roger FL, Solano P, Bouyer J, Porphyre V, Berthier D, Peyre M, Bonnet P.

PLoS Negl Trop Dis. 2017 Sep 7;11(9):e0005843. doi: 10.1371/journal.pntd.0005843. eCollection 2017 Sep. No abstract available.

8.

Comprehensive Network Map of ADME-Tox Databases.

Canault B, Bourg S, Vayer P, Bonnet P.

Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700029. Epub 2017 Jun 29.

PMID:
28660674
9.

VSPrep: A General KNIME Workflow for the Preparation of Molecules for Virtual Screening.

Gally JM, Bourg S, Do QT, Aci-Sèche S, Bonnet P.

Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700023. Epub 2017 Jun 6.

PMID:
28586180
10.

Enantioseparation of novel chiral sulfoxides on chlorinated polysaccharide stationary phases in supercritical fluid chromatography.

West C, Konjaria ML, Shashviashvili N, Lemasson E, Bonnet P, Kakava R, Volonterio A, Chankvetadze B.

J Chromatogr A. 2017 May 26;1499:174-182. doi: 10.1016/j.chroma.2017.03.089. Epub 2017 Apr 4.

PMID:
28404372
11.

The use of novel selectivity metrics in kinase research.

Bosc N, Meyer C, Bonnet P.

BMC Bioinformatics. 2017 Jan 5;18(1):17. doi: 10.1186/s12859-016-1413-y.

12.

Prediction of Protein Kinase-Ligand Interactions through 2.5D Kinochemometrics.

Bosc N, Wroblowski B, Meyer C, Bonnet P.

J Chem Inf Model. 2017 Jan 23;57(1):93-101. doi: 10.1021/acs.jcim.6b00520. Epub 2017 Jan 3.

PMID:
27983837
13.

An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases.

Chaikuad A, Diharce J, Schröder M, Foucourt A, Leblond B, Casagrande AS, Désiré L, Bonnet P, Knapp S, Besson T.

J Med Chem. 2016 Nov 23;59(22):10315-10321. Epub 2016 Nov 2.

PMID:
27766861
14.

Correction to Structural Investigation of B-Raf Paradox Breaker and Inducer Inhibitors.

Arora R, Di Michele M, Stes E, Vandermarliere E, Martens L, Gevaert K, Van Heerde E, Linders JT, Brehmer D, Jacoby E, Bonnet P.

J Med Chem. 2016 Jul 28;59(14):6973. doi: 10.1021/acs.jmedchem.6b00941. Epub 2016 Jul 6. No abstract available.

PMID:
27385554
15.

Advanced molecular dynamics simulation methods for kinase drug discovery.

Aci-Sèche S, Ziada S, Braka A, Arora R, Bonnet P.

Future Med Chem. 2016 Apr;8(5):545-66. doi: 10.4155/fmc.16.9. Epub 2016 Apr 7. Review.

PMID:
27054816
16.

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.

Ouach A, Boulahjar R, Vala C, Bourg S, Bonnet P, Guguen-Guillouzo C, Ravache M, Le Guevel R, Lozach O, Lazar S, Troin Y, Meijer L, Ruchaud S, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem. 2016 Jun 10;115:311-25. doi: 10.1016/j.ejmech.2016.02.072. Epub 2016 Mar 2.

PMID:
27019296
17.

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.

Albesa-Jové D, Svetlíková Z, Tersa M, Sancho-Vaello E, Carreras-González A, Bonnet P, Arrasate P, Eguskiza A, Angala SK, Cifuente JO, Korduláková J, Jackson M, Mikušová K, Guerin ME.

Nat Commun. 2016 Mar 11;7:10906. doi: 10.1038/ncomms10906.

18.

Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase.

Sari O, Roy V, Métifiot M, Marchand C, Pommier Y, Bourg S, Bonnet P, Schinazi RF, Agrofoglio LA.

Eur J Med Chem. 2015 Nov 2;104:127-38. doi: 10.1016/j.ejmech.2015.09.015. Epub 2015 Sep 25.

19.

A Proteometric Analysis of Human Kinome: Insight into Discriminant Conformation-dependent Residues.

Bosc N, Wroblowski B, Aci-Sèche S, Meyer C, Bonnet P.

ACS Chem Biol. 2015 Dec 18;10(12):2827-40. doi: 10.1021/acschembio.5b00555. Epub 2015 Oct 16.

PMID:
26411811
20.

Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules.

Di Michele M, Stes E, Vandermarliere E, Arora R, Astorga-Wells J, Vandenbussche J, van Heerde E, Zubarev R, Bonnet P, Linders JT, Jacoby E, Brehmer D, Martens L, Gevaert K.

J Proteome Res. 2015 Oct 2;14(10):4179-93. doi: 10.1021/acs.jproteome.5b00282. Epub 2015 Aug 25.

PMID:
26293246

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