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Methacycline displays a strong efficacy in reducing toxicity in a SCA3 Caenorhabditis elegans model.

Amigoni L, Airoldi C, Natalello A, Romeo M, Diomede L, Tortora P, Regonesi ME.

Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):279-290. doi: 10.1016/j.bbagen.2018.10.008. Epub 2018 Oct 27.


Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms.

Giorgetti S, Greco C, Tortora P, Aprile FA.

Int J Mol Sci. 2018 Sep 9;19(9). pii: E2677. doi: 10.3390/ijms19092677. Review.


Protein Environment: A Crucial Triggering Factor in Josephin Domain Aggregation: The Role of 2,2,2-Trifluoroethanol.

Visentin C, Navarro S, Grasso G, Regonesi ME, Deriu MA, Tortora P, Ventura S.

Int J Mol Sci. 2018 Jul 24;19(8). pii: E2151. doi: 10.3390/ijms19082151.


A fast and straightforward procedure for vault nanoparticle purification and the characterization of its endocytic uptake.

Galbiati E, Avvakumova S, La Rocca A, Pozzi M, Messali S, Magnaghi P, Colombo M, Prosperi D, Tortora P.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2254-2260. doi: 10.1016/j.bbagen.2018.07.018. Epub 2018 Jul 20.


Publisher Correction: The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.

Bonanomi M, Roffia V, De Palma A, Lombardi A, Aprile FA, Visentin C, Tortora P, Mauri P, Regonesi ME.

Sci Rep. 2018 Mar 6;8(1):4285. doi: 10.1038/s41598-018-22523-2.


A High Sensitivity Biosensor to detect the presence of perfluorinated compounds in environment.

Cennamo N, Zeni L, Tortora P, Regonesi ME, Giusti A, Staiano M, D'Auria S, Varriale A.

Talanta. 2018 Feb 1;178:955-961. doi: 10.1016/j.talanta.2017.10.034. Epub 2017 Oct 21.


The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.

Bonanomi M, Roffia V, De Palma A, Lombardi A, Aprile FA, Visentin C, Tortora P, Mauri P, Regonesi ME.

Sci Rep. 2017 Oct 17;7(1):13417. doi: 10.1038/s41598-017-13814-1. Erratum in: Sci Rep. 2018 Mar 6;8(1):4285.


Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.

Visentin C, Pellistri F, Natalello A, Vertemara J, Bonanomi M, Gatta E, Penco A, Relini A, De Gioia L, Airoldi C, Regonesi ME, Tortora P.

Hum Mol Genet. 2017 Sep 1;26(17):3271-3284. doi: 10.1093/hmg/ddx211.


Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations.

Salvioni L, Galbiati E, Collico V, Alessio G, Avvakumova S, Corsi F, Tortora P, Prosperi D, Colombo M.

Int J Nanomedicine. 2017 Mar 31;12:2517-2530. doi: 10.2147/IJN.S127799. eCollection 2017.


Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N.

Biochemistry. 2017 Mar 7;56(9):1177-1180. doi: 10.1021/acs.biochem.6b01178. Epub 2017 Feb 23.


How Epigallocatechin-3-gallate and Tetracycline Interact with the Josephin Domain of Ataxin-3 and Alter Its Aggregation Mode.

Bonanomi M, Visentin C, Natalello A, Spinelli M, Vanoni M, Airoldi C, Regonesi ME, Tortora P.

Chemistry. 2015 Dec 7;21(50):18383-93. doi: 10.1002/chem.201503086. Epub 2015 Nov 5.


The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model.

Bonanomi M, Visentin C, Invernizzi G, Tortora P, Regonesi ME.

PLoS One. 2015 Jun 8;10(6):e0129727. doi: 10.1371/journal.pone.0129727. eCollection 2015.


Peptide-nanoparticle ligation mediated by cutinase fusion for the development of cancer cell-targeted nanoconjugates.

Galbiati E, Cassani M, Verderio P, Martegani E, Colombo M, Tortora P, Mazzucchelli S, Prosperi D.

Bioconjug Chem. 2015 Apr 15;26(4):680-9. doi: 10.1021/acs.bioconjchem.5b00005. Epub 2015 Mar 13.


Protein nanocages for self-triggered nuclear delivery of DNA-targeted chemotherapeutics in Cancer Cells.

Bellini M, Mazzucchelli S, Galbiati E, Sommaruga S, Fiandra L, Truffi M, Rizzuto MA, Colombo M, Tortora P, Corsi F, Prosperi D.

J Control Release. 2014 Dec 28;196:184-96. doi: 10.1016/j.jconrel.2014.10.002. Epub 2014 Oct 13.


Immobilization of carboxypeptidase from Sulfolobus solfataricus on magnetic nanoparticles improves enzyme stability and functionality in organic media.

Sommaruga S, Galbiati E, Peñaranda-Avila J, Brambilla C, Tortora P, Colombo M, Prosperi D.

BMC Biotechnol. 2014 Sep 5;14:82. doi: 10.1186/1472-6750-14-82.


Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.

Bonanomi M, Natalello A, Visentin C, Pastori V, Penco A, Cornelli G, Colombo G, Malabarba MG, Doglia SM, Relini A, Regonesi ME, Tortora P.

Hum Mol Genet. 2014 Dec 15;23(24):6542-52. doi: 10.1093/hmg/ddu373. Epub 2014 Jul 16.


Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome.

Bonanomi M, Mazzucchelli S, D'Urzo A, Nardini M, Konarev PV, Invernizzi G, Svergun DI, Vanoni M, Regonesi ME, Tortora P.

Int J Biochem Cell Biol. 2014 Jun;51:58-64. doi: 10.1016/j.biocel.2014.03.015. Epub 2014 Mar 28.


Biotechnological approaches toward nanoparticle biofunctionalization.

Avvakumova S, Colombo M, Tortora P, Prosperi D.

Trends Biotechnol. 2014 Jan;32(1):11-20. doi: 10.1016/j.tibtech.2013.09.006. Epub 2013 Oct 30. Review.


A conserved loop in polynucleotide phosphorylase (PNPase) essential for both RNA and ADP/phosphate binding.

Carzaniga T, Mazzantini E, Nardini M, Regonesi ME, Greco C, Briani F, De Gioia L, Dehò G, Tortora P.

Biochimie. 2014 Feb;97:49-59. doi: 10.1016/j.biochi.2013.09.018. Epub 2013 Sep 26.


Different ataxin-3 amyloid aggregates induce intracellular Ca(2+) deregulation by different mechanisms in cerebellar granule cells.

Pellistri F, Bucciantini M, Invernizzi G, Gatta E, Penco A, Frana AM, Nosi D, Relini A, Regonesi ME, Gliozzi A, Tortora P, Robello M, Stefani M.

Biochim Biophys Acta. 2013 Dec;1833(12):3155-3165. doi: 10.1016/j.bbamcr.2013.08.019. Epub 2013 Sep 11.

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