Format

Send to

Choose Destination
Mar Drugs. 2018 Jul 24;16(8). pii: E247. doi: 10.3390/md16080247.

On the Neuroprotective Role of Astaxanthin: New Perspectives?

Author information

1
Marine BiotechnologyDepartment, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. christian.galasso@szn.it.
2
Marine BiotechnologyDepartment, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. ida.orefice@szn.it.
3
Marine BiotechnologyDepartment, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. paola.pellone@gmail.com.
4
Research Infrastructures for marine biological resources Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. paola.cirino@szn.it.
5
Marine BiotechnologyDepartment, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. robertamiele90@libero.it.
6
Marine BiotechnologyDepartment, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. adrianna.ianora@szn.it.
7
Marine BiotechnologyDepartment, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. christophe.brunet@szn.it.
8
Marine BiotechnologyDepartment, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy. clementina.sansone@szn.it.

Abstract

Astaxanthin is a carotenoid with powerful antioxidant and anti-inflammatory activity produced by several freshwater and marine microorganisms, including bacteria, yeast, fungi, and microalgae. Due to its deep red-orange color it confers a reddish hue to the flesh of salmon, shrimps, lobsters, and crayfish that feed on astaxanthin-producing organisms, which helps protect their immune system and increase their fertility. From the nutritional point of view, astaxanthin is considered one of the strongest antioxidants in nature, due to its high scavenging potential of free radicals in the human body. Recently, astaxanthin is also receiving attention for its effect on the prevention or co-treatment of neurological pathologies, including Alzheimer and Parkinson diseases. In this review, we focus on the neuroprotective properties of astaxanthin and explore the underlying mechanisms to counteract neurological diseases, mainly based on its capability to cross the blood-brain barrier and its oxidative, anti-inflammatory, and anti-apoptotic properties.

KEYWORDS:

astaxanthin; neuroactive carotenoids; neurodegenerative diseases; neuroinflammation; neuroprotective effect

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center