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Items: 1 to 20 of 38


The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB.

Zhu Z, Schnell L, Müller B, Müller M, Papatheodorou P, Barth H.

Stem Cells Int. 2019 Aug 5;2019:4149762. doi: 10.1155/2019/4149762. eCollection 2019.


Inappropriate Use of Public Hospitals Emergency Departments in Greece: Magnitude and Associated Factors.

Galanis P, Siskou O, Charalambous G, Konstantakopoulou O, Liarigkovinou A, Karagkouni I, Tsolas G, Chatzi P, Giotaki A, Keramidas G, Nikolakakou A, Papachristou A, Papatheodorou P, Papastefanopoulou V, Skountzos I, Thermogianni A, Kaitelidou D.

Stud Health Technol Inform. 2019 Jul 4;262:224-227. doi: 10.3233/SHTI190059.


Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors.

López-Ureña D, Orozco-Aguilar J, Chaves-Madrigal Y, Ramírez-Mata A, Villalobos-Jimenez A, Ost S, Quesada-Gómez C, Rodríguez C, Papatheodorou P, Chaves-Olarte E.

Toxins (Basel). 2019 Jun 17;11(6). pii: E348. doi: 10.3390/toxins11060348.


Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication.

Schnell L, Felix I, Müller B, Sadi M, von Bank F, Papatheodorou P, Popoff MR, Aktories K, Waltenberger E, Benz R, Weichbrodt C, Fauler M, Frick M, Barth H.

FASEB J. 2019 Apr;33(4):5755-5771. doi: 10.1096/fj.201802453R. Epub 2019 Jan 30.


Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.

Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K.

FASEB J. 2019 Apr;33(4):4883-4892. doi: 10.1096/fj.201801440R. Epub 2018 Dec 28.


Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication.

di Masi A, Leboffe L, Polticelli F, Tonon F, Zennaro C, Caterino M, Stano P, Fischer S, Hägele M, Müller M, Kleger A, Papatheodorou P, Nocca G, Arcovito A, Gori A, Ruoppolo M, Barth H, Petrosillo N, Ascenzi P, Di Bella S.

J Infect Dis. 2018 Sep 22;218(9):1424-1435. doi: 10.1093/infdis/jiy338.


Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL.

Schorch B, Heni H, Zahaf NI, Brummer T, Mione M, Schmidt G, Papatheodorou P, Aktories K.

Oncotarget. 2018 Mar 27;9(23):16489-16500. doi: 10.18632/oncotarget.24740. eCollection 2018 Mar 27.


Binary Clostridium difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton.

Aktories K, Papatheodorou P, Schwan C.

Anaerobe. 2018 Oct;53:21-29. doi: 10.1016/j.anaerobe.2018.03.001. Epub 2018 Mar 7. Review.


Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins.

Papatheodorou P, Barth H, Minton N, Aktories K.

Adv Exp Med Biol. 2018;1050:77-96. doi: 10.1007/978-3-319-72799-8_6. Review.


Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins.

Papatheodorou P, Aktories K.

Curr Top Microbiol Immunol. 2017;406:119-133. doi: 10.1007/82_2016_46. Review.


Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells.

Czulkies BA, Mastroianni J, Lutz L, Lang S, Schwan C, Schmidt G, Lassmann S, Zeiser R, Aktories K, Papatheodorou P.

Oncotarget. 2017 Jun 6;8(23):37009-37022. doi: 10.18632/oncotarget.10425.


Preface for Anaerobe - Special issue on Clostpath9.

Papatheodorou P, Aktories K.

Anaerobe. 2016 Oct;41:1. doi: 10.1016/j.anaerobe.2016.04.008. Epub 2016 Apr 11. No abstract available.


Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR).

Hemmasi S, Czulkies BA, Schorch B, Veit A, Aktories K, Papatheodorou P.

J Biol Chem. 2015 May 29;290(22):14031-44. doi: 10.1074/jbc.M115.650523. Epub 2015 Apr 16.


Novel receptors for bacterial protein toxins.

Schmidt G, Papatheodorou P, Aktories K.

Curr Opin Microbiol. 2015 Feb;23:55-61. doi: 10.1016/j.mib.2014.11.003. Epub 2014 Nov 22. Review.


LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Schorch B, Song S, van Diemen FR, Bock HH, May P, Herz J, Brummelkamp TR, Papatheodorou P, Aktories K.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6431-6. doi: 10.1073/pnas.1323790111. Epub 2014 Apr 15.


Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1).

Piteau M, Papatheodorou P, Schwan C, Schlosser A, Aktories K, Schmidt G.

PLoS Pathog. 2014 Jan;10(1):e1003884. doi: 10.1371/journal.ppat.1003884. Epub 2014 Jan 16. Erratum in: PLoS Pathog. 2014 Jan;10(1). doi:10.1371/annotation/6eec6403-e090-4283-aa34-34cc58ca0bbb.


The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases.

Lang AE, Ernst K, Lee H, Papatheodorou P, Schwan C, Barth H, Aktories K.

Cell Microbiol. 2014 Apr;16(4):490-503. doi: 10.1111/cmi.12228. Epub 2013 Nov 5.


Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis.

Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K, Orth JH.

PLoS Pathog. 2013;9(5):e1003385. doi: 10.1371/journal.ppat.1003385. Epub 2013 May 16.


Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts.

Papatheodorou P, Hornuss D, Nölke T, Hemmasi S, Castonguay J, Picchianti M, Aktories K.

MBio. 2013 Apr 30;4(3):e00244-13. doi: 10.1128/mBio.00244-13.


Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-O-GlcNAcylation of Ras in living cells.

Guttenberg G, Hornei S, Jank T, Schwan C, Lü W, Einsle O, Papatheodorou P, Aktories K.

J Biol Chem. 2012 Jul 20;287(30):24929-40. doi: 10.1074/jbc.M112.347773. Epub 2012 Jun 4.

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