Format

Send to

Choose Destination
Molecules. 2018 Sep 11;23(9). pii: E2322. doi: 10.3390/molecules23092322.

Phenolic Compounds in Honey and Their Associated Health Benefits: A Review.

Author information

1
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. danila.cianciosi@gmail.com.
2
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. tamara.forbe@gmail.com.
3
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. dolla.bihs@gmail.com.
4
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. m.gasparrini@univpm.it.
5
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. preboredo@uvigo.es.
6
Departamento de Química Analítica y Alimentaria, Grupo de Nutrición y Bromatología, Universidade de Vigo, 32004 Ourense, Spain. preboredo@uvigo.es.
7
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. p.piera@hotmail.it.
8
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. zh.jojo@yahoo.com.
9
Center for Nutrition & Health, Universidad Europea del Atlántico (UEA), 39011 Santander, Spain; leire.bravo@uneatlantico.es (L.B.L.). leire.bravo@uneatlantico.es.
10
Center for Nutrition & Health, Universidad Europea del Atlántico (UEA), 39011 Santander, Spain; leire.bravo@uneatlantico.es (L.B.L.). susana.martinez@uneatlantico.es.
11
Center for Nutrition & Health, Universidad Europea del Atlántico (UEA), 39011 Santander, Spain; leire.bravo@uneatlantico.es (L.B.L.). pablo.agudo@uneatlantico.es.
12
Department of Physiology, Institute of Nutrition and Food Technology "Jose Mataix", Biomedical Research Centre, University of Granada, Armilla, 18100 Granada, Spain. jlquiles@ugr.es.
13
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. f.giampieri@univpm.it.
14
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. m.a.battino@univpm.it.

Abstract

Honey is a natural substance appreciated for its therapeutic abilities since ancient times. Its content in flavonoids and phenolic acids plays a key role on human health, thanks to the high antioxidant and anti-inflammatory properties that they exert. Honey possesses antimicrobial capacity and anticancer activity against different types of tumors, acting on different molecular pathways that are involved on cellular proliferation. In addition, an antidiabetic activity has also been highlighted, with the reduction of glucose, fructosamine, and glycosylated hemoglobin serum concentration. Honey exerts also a protective effect in the cardiovascular system, where it mainly prevents the oxidation of low-density lipoproteins, in the nervous system, in the respiratory system against asthma and bacterial infections, and in the gastrointestinal system. A beneficial effect of honey can also be demonstrated in athletes. The purpose of this review is to summarize and update the current information regarding the role of honey in health and diseases.

KEYWORDS:

antimicrobial activities; antioxidants; cancer; diabetes; disease prevention; honey; polyphenols

PMID:
30208664
PMCID:
PMC6225430
DOI:
10.3390/molecules23092322
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center